Dan L. Longo

最終学歴

米国ミズリー大学 医学士

現職

  • 米国ハーバード大学 医学部 内科学教授
  • ニューイングランド・ジャーナル・オブ・メデシィン副編集長

職歴

  • 1972-1973 – Post-Sophomore Fellow, Department of Pathology, University of Missouri, Columbia, Missouri
  • 1974-1975 – Research in the Laboratory of Dr. Victor Herbert, Department of Pathology, Columbia University College of Physicians and Surgeons, New York, New York
  • 1975-1976 – Medical House Officer, Peter Bent Brigham Hospital, Boston, Massachusetts
  • 1976-1977 – Assistant Resident in Medicine, Peter Bent Brigham Hospital, Boston, Massachusetts
  • 1975-1977 – Clinical Fellow in Medicine, Harvard Medical School, Boston, Massachusetts
  • 1977-1978 – Clinical Associate, Medicine Branch, National Cancer Institute, Bethesda, Maryland
  • 1978-1980 – Clinical Associate, Laboratory of Immunology, National Institute of Allergy and Infectious Disease, Bethesda, Maryland
  • 1980-1982 – Senior Investigator, Medicine Branch, National Cancer Institute, Bethesda, Maryland
  • 1982-1985 – Head, Experimental Immunology Section, Medicine Branch, National Cancer Institute, Bethesda, Maryland
  • 1985-1995 – Director, Biological Response Modifiers Program,
    Associate Director, Division of Cancer Treatment, National Cancer Institute, Frederick, Maryland
  • 1995-2010 – Scientific Director, National Institute on Aging, National Institutes of
    Health, Baltimore and Bethesda, Maryland
  • 2010-pres – Deputy Editor, New England Journal of Medicine, Boston
  • 2011-pres – Professor of Medicine, Harvard Medical School, Boston Senior Physician, Brigham and Women’s Hospital, Boston

賞罰

      • 1965, Harvard Book Award
      • 1966, University of Missouri Curators Award
      • 1975-76 and 1976-77, Radiology Case-of-the-Week Award, Peter Bent Brigham Hospital
At the University of Missouri School of Medicine:
  • 1971, Physiology Award
  • 1972-3, Post-Sophomore Fellowship in Pathology
  • 1973, Lange Book Award
  • 1974, Alpha Omega Alpha
  • 1974, Lange Book Award
  • 1975, Phi Kappa Phi
  • 1975, Internal Medicine Award
  • 1987, Young Physician Award (by Alumni Association)
  • 1997, Citation of Merit for Contributions to Medicine (by Alumni Association)
United States Public Health Service:
  • 1984, Outstanding Unit Citation
  • 1987, Commendation Medal
  • 1988, Unit Commendation
  • 1992, Outstanding Service Medal
  • 1993, NIH Merit Award
  • 1996, NIH Director’s Award
  • 2005, Outstanding Service Medal
  • 2010, NIH Director’s Award
  • Other Awards:
  • 1992-1993, Listing in The Best Doctors in America, First Edition, Edited by Naifeh, S. and Smith, G.W., Woodward/White, Inc. Publishers, pp. 165.
  • 1992, Listing in Good Housekeeping Magazine “400 Best Cancer Doctors”,October Issue
  • 1992, Tovi Comet-Walerstein Award, Cancer AIDS and Immunology Research Institute, Bar-Ilan University, Ramat-Gan, Israel–presented June 6, 1993
  • 1994-1995, Listing in The Best Doctors in America, Second Edition, Edited by Naifeh, S. and Smith, G.W., Woodward/White, Inc. Publishers, pp. 269.
  • 1996-1997, Listing in The Best Doctors in America, Third Edition, Edited by Naifeh, S. and Smith, G.W., Woodward/White, Inc. Publishers,
  • 1998-1999, Listing in The Best Doctors in America, Fourth Edition
  • 2000-2001, Listing in The Best Doctors in America, Fifth Edition
  • 2001-pres, Listing in every edition of The Best Doctors in America
  • 2002 Listing in ISI’s Highly Cited Researchers
    Other Awards (continued):
  • 2002 Elected to Membership in the European Academy of Sciences
  • 2005 Top 1% of cited authors in life sciences
  • 2010 Team Science Recognition Award, International Society for Biologic Therapy

研究業績

A) 学術論文 英文
1. Longo, D., Kwan, C., Cherrick, H., and Apirion, D.: Escherichia coli strains with modified RNase II activity: isolation and properties. Molec. Gen. Genetics 110: 54-60, 1971. PMID: 4927442

2. Corte, G., Schlessinger, D., Longo, D., and Venkov, P.: Transformation of 17S to 16S ribosomal RNA using ribonuclease II of Escherichia coli. J. Molec. Biol. 60: 325-338, 1971. PMID: 4938733

3. Venkov, P., Schlessinger, D., and Longo, D.: Inhibition of ribonuclease II of Escherichia coli by sodium ions, adenosine-5′-triphosphate, and transfer ribonucleic acid. J. Bacteriol. 108: 601-603, 1971. PMID: 4941574

4. Longo, D.L.: Mechanisms of renal disease. An audiovisual educational tool to introduce the genitourinary system in a course in systemic pathology. University of Missouri-Columbia Educational Resources Group, 1974.

5. Longo, D.L. and Herbert, V.: Radioassay for serum and red cell folate. J. Lab. Clin. Med. 87: 138-151, 1976. PMID: 1452

6. Longo, D.L., Senhauser, D.A., Taylor, D.D., and Lucas, F.V.: University of Missouri-Columbia School of Medicine Postsophomore Pathology Fellowship Program. J. Med. Education 51: 340-342, 1976. PMID: 1255694

7. Mease, A.D., Longo, D.L., and Hakami, N.: Sicklemia and unexpected death in sickle cell trait: observations of five cases. Military Med. 141: 470-473, 1976. PMID: 819874

8. Colman, N., Longo, D.L., and Herbert, V.: Folate radioassay and crude milk binder. Blood 48: 626-627, 1976. PMID: 822901

9. Grim, C.E., Keitzer, W.F., Esterly, J.A., and Longo, D.L.: The inappropriate secretion of aldosterone associated with adrenal hyperplasia. University of Michigan Med. J. 42: 54-59, 1976.

10. Longo, D.L.: Hypokalemia in leukemia. Blood 50: 749, 1977. PMID: 901944

11. Longo, D.L. and Larsen, P.R.: Evaluation of suspected thyroid dysfunction. Comprehensive Therapy 3: #ll, l6-22, 1977. PMID: 923198

12. Longo, D.L., Esterly, J.A., Grim, C.E., and Keitzer, W.F.: Pathology of the adrenal gland in refractory low-renin hypertension. Arch. Pathol. Lab. Med. 102: 322-327, 1978. PMID: 580727

13. Das, K.C., Herbert, V., Colman, N., and Longo, D.L.: Unmasking covert folate deficiency in iron-deficient subjects with neutrophil hypersegmentation: dU suppression tests on lymphocytes and bone marrow. Br. J. Haematol. 39: 357-375, 1978. PMID: 698114

14. Longo, D.L., Whang-Peng, J., Jaffe, E., Triche, T.J., and Young, R.C.: Myeloproliferative syndromes: a unique presentation of chronic myelogenous leukemia (CML) as a primary tumor of bone. Blood 52: 793-801, 1978. PMID: 278632

15. Brereton, H.D., Young, R.C., Longo, D.L., Kirkland, L.R., Berard, C.W., Jaffe, E.S., DeVita, V.T., and Johnson, R.E.: A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin’s lymphoma. Cancer 43: 2227-2231, 1979. PMID: 378350

16. Longo, D.L. and Young, R.C.: Cosmetic talc and ovarian cancer. Lancet ii: 349-351,
1979. PMID: 89403 Letter, ii, 1009-1012, 1979. PMID: 91731
17. Longo, D.L. and Witherspoon, J.M.: Focal neurologic symptoms in hypercalcemia. Neurology 30: 200-201, 1980. PMID: 7188801

18. Kirkland, T.N., Sieckmann, D.G., Longo, D.L., and Mosier, D.E.: Cellular requirements for antigen presentation in the induction of a thymus-independent antibody response in vitro. J. Immunol. 124: 1721-1726, 1980. PMID: 6965958

19. Longo, D.L. and Young, R.C.: Ovarian cancer: current treatment and new
prospects. In van Ossterom, A. and Muggia, F.M. (Eds.): Therapeutic Progress in Ovarian Cancer, Testicular Cancer and the Sarcomas. The Hague, Martinus Nijhoff Publishers, 1980, pp. 61-75.
20. Longo, D.L., Schilsky, R.L., Blei, L., Cano, R., Johnston, G.S., and Young, R.C.: Gallium-67 scanning: limited usefulness in staging patients with non-Hodgkin’s lymphoma. Am. J. Med. 68: 695-700, 1980. PMID: 6769331

21. Longo, D.L. and Schwartz, R.H.: Gene complementation: neither Ir-GL gene need be present in the proliferative T cell to generate an immune response to poly (Glu55Lys36Phe9)n. J. Exp. Med. 151: 1452-1467, 1980. PMID: 6770025

22. Longo, D.L.: More on lithium and leukemia. N. Engl. J. Med. 303: 283, 1980. PMID: 7383116

23. Longo, D.L. and Schwartz, R.H.: T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Nature 287: 44-46, 1980. PMID: 6774265

24. Longo, D.L. and Schwartz, R.H.: Inhibition of antigen-induced proliferation of T cells from radiation-induced bone marrow chimeras by a monoclonal antibody directed against an Ia determinant on the antigen-presenting cell. Proc. Natl. Acad. Sci. USA 78: 514-518, 1981. PMID: 6165995

25. Longo, D.L., Matis, L.A., and Schwartz, R.H.: Insights into immune response gene function from experiments with chimeric animals. CRC Crit. Rev. Immunol. 2: 83-132, 1981.

26. Longo, D.L. and Young, R.C.: The natural history and treatment of ovarian cancer. Annu. Rev. Med. 32: 475-490, 1981. PMID: 7013683

27. Seigel, L.J. and Longo, D.L.: The control of chemotherapy-induced emesis. Ann. Intern. Med. 95: 352-359, 1981. PMID: 7023313

28. Rubinstein, D.B. and Longo, D.L.: Peripheral destruction of platelets in chronic lymphocytic leukemia: recognition, prognosis and therapeutic implications. Am. J. Med. 71: 729-732, 1981. PMID: 7025627

29. Glimcher, L.H., Longo, D.L., Green, I., and Schwartz, R.H.: Murine syngeneic mixed lymphocyte response. I. Target antigens are self Ia molecules. J. Exp. Med. 154: 1652-1670, 1981. PMID: 6170721

30. Longo, D.L., Young, R.C., and DeVita, V.T.: What is so good about the `good prognosis’ lymphomas? In Williams, C.J. and Whitehouse, J.M.A. (Eds.): Recent Advances in Clinical Oncology, No. 1. Edinburgh, Churchill-Livingstone, Ltd., 1982, pp. 223-231.

31. Longo, D.L. and Paul, W.E.: Immune response genes and Ia antigens. The relationships between them and their role in lymphocyte interactions. In Parham, P. and Strominger, J.L. (Eds.): Histocompatibility Antigens Structure and Function. London, Chapman & Hall, Ltd., 1982, pp. 161-185.

32. Tse, H.Y., Mond, J.J., and Longo, D.L.: B lymphocyte immune response gene phenotype is genetically determined. J. Exp. Med. 155: 1239-1244, 1982. PMID: 6801187

33. Longo, D.L., Young, R.C., and DeVita, V.T., Jr.: Chemotherapy for Hodgkin’s disease: the remaining challenges. Cancer Treat. Rep. 66: 925-936, 1982. PMID: 7042091

34. Schwartz, R.H., Glimcher, L.H., Hedrick, S.M., Singer, A., and Longo, D.L.: Restriction to thymic major histocompatibility complex (MHC) and immune response (Ir) phenotype of T cells from allogeneic chimeras. Behring Institute Research Communications. 70: 155-162, 1982 (meeting summarized in Science 214: 893-896, 1981).

35. Blayney, D.W. and Longo, D.: Case 44-1981: radiation-induced pericarditis. N. Engl. J. Med. 306: 550, 1982.

36. Glimcher, L.H., Schwartz, R.H., Longo, D.L., and Singer, A.: The specificity of the syngeneic mixed leukocyte response, a primary anti-I region T cell proliferative response, is determined intrathymically. J. Immunol. 129: 987-991, 1982. PMID: 6213713

37. Hedrick, S.M., Matis, L.A., Hecht, T.T., Samelson, L.E., Longo, D.L., Heber-Katz, E., and Schwartz, R.H.: The fine specificity of antigen and Ia determinant recognition by T cell hybridoma clones specific for pigeon cytochrome c. Cell 30: 141-152, 1982. PMID: 6213713

38. Longo, D.L. and DeVita, V.T., Jr.: Lymphomas. In Pinedo, H.M. (Ed.): Cancer Chemotherapy Annual 4. Amsterdam, Elsevier Science Publishers B.V., 1982, pp. 197-234.

39. Longo, D.L., Wesley, M., Howser, D., Hubbard, S.M., Anderson, T., and Young, R.C.: Results of a randomized double-blind crossover trial of scopolamine versus placebo administered by transdermal patch for the control of cisplatin-induced emesis. Cancer Treat. Rep. 66: 1975-1976, 1982. PMID: 6890407

40. Thomas, J.L., Bernardino, M.E., Vermess, M., Barnes, P.A., Fuller, L.M., Hagemeister, F.B., Doppman, J., Fisher, R.I., and Longo, D.L.: EOE-l3 in the detection of hepatosplenic lymphoma. Radiology 145: 629-634, 1982. PMID: 6292995

41. Messerschmidt, G.L., Bowles, C., Parrillo, J., Parker, M., Shelhammer, J., Dowling, R., Osborne, L., Corbitt, R., McCormack, K., Longo, D., and Deisseroth, A.: The use of protein-A in the treatment of malignancy: rationale and the NCI experience. In Tindall, R.S.A. (Ed.): Therapeutic Apheresis and Plasma Perfusion. Proceedings of the Third National Conference on Therapeutic Apheresis, Dallas, Texas, May l3-l5, 1982. New York, Alan R. Liss, Inc., 1982, pp. 385-390 and Prog. Clin. Biol. Res. 106:385-390, 1982. PMID: 6757952

42. Blayney, D.W. and Longo, D.L.: Ovarian cancer: epidemiology, diagnosis, and management. Comprehensive Therapy 9: 50-58, 1983. PMID: 6831853

43. Matis, L.A., Longo, D.L., Hedrick, S.M., Hannum, C., Margoliash, E., and Schwartz, R.H.: Clonal analysis of the major histocompatibility complex restriction and the fine specificity of antigen recognition in the T cell proliferative response to cytochrome c. J. Immunol. 130: 1527-1535, 1983. PMID: 6187812

44. Matis, L.A., Schwartz, R.H., Davis, M., and Longo, D.L.: The contributions of the developmental and priming environments to the expression of the T cell receptor repertoire. In Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., and Shreffler, D.C. (Eds.): Ir Genes: Past, Present, and Future. The Proceedings of the 5th Ir Gene Workshop. New Jersey, Humana Press, 1983, pp. 419-423.

45. Matis, L.A., Glimcher, L., Lindgren, A., Longo, D.L., and Schwartz, R.H.: The effect of nominal antigen and Ia molecule concentrations on the magnitude of the proliferative response of T cell clones. In Pierce, C.W., Cullen, S.E., Kapp, J.A., Schwartz, B.D., and Shreffler, D.C. (Eds.): Ir Genes: Past, Present, and Future. The Proceedings of the 5th Ir Gene Workshop. New Jersey, Humana Press, 1983, pp. 439-443.

46. Fisher, R.I., DeVita, V.T., Jr., Hubbard, S.M., Longo, D.L., Wesley, R., Chabner, B.A., and Young, R.C.: Diffuse aggressive lymphomas: increased survival after alternating flexible sequences of ProMACE and MOPP chemotherapy. Ann. Intern. Med. 98: 304-309, 1983.
PMID: 6600902

47. Longo, D.L. and Fisher, R.I.: Medical problems in long-term survivors of Hodgkin’s disease. Internal Medicine for the Specialist 4: 165-l71, 1983.

48. Longo, D.L. and Davis, M.L.: Early appearance of donor-type antigen-presenting cells in the thymuses of l200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene products. J. Immunol. 130: 2525-2527, 1983. PMID: 6406592

49. Foss, F.M., Horneff, J., Longo, D.L., and Messerschmidt, G.L.: Cerebrospinal fluid rhinorrhea as a complication of malignant lymphoma. Am. J. Med. 74: 1077-1079, 1983.
PMID: 6859057

50. Blayney, D.W., Jaffe, E.S., Blattner, W.A., Cossman, J., Robert-Guroff, M., Longo, D.L., Bunn, P.A., Jr., and Gallo, R.C.: The human T-cell leukemia/ lymphoma virus associated with American adult T-cell leukemia/lymphoma. Blood 62: 401-405, 1983. PMID: 6223675

51. Hecht, T.T., Longo, D.L., and Matis, L.A.: The relationship between immune interferon production and proliferation in antigen-specific, MHC-restricted T cell lines and clones. J. Immunol. 131: 1049-1055, 1983. PMID: 6193170

52. Macher, A.M., Reichert, C.M., Straus, S.E., Longo, D.L., Parrillo, J., Lane, H.C., Fauci, A.S., Rook, A.H., Manischewitz, J.F., and Quinnan, G.V.: Death in the AIDS patient: role of cytomegalovirus. N. Engl. J. Med. 309: 1454, 1983. PMID: 6314141

53. Longo, D.L. and DeVita, V.T., Jr.: Lymphomas. In Pinedo, H.M. and Chabner, B.A. (Eds.): Cancer Chemotherapy Annual 5. New York, Elsevier, 1983, pp. 248-281.

54. Straus, S.E., Armstrong, G., Seidlin, M., Horneff, J., Clark, J., Faggioni, A., Pearson, G., Ablashi, D.V., and Longo, D.: Acyclovir treatment of human herpesvirus infections: implications for the treatment of Epstein-Barr virus (EBV)-related disorders. In Prasad, et al. (Eds.): Nasopharyngeal Carcinoma: Current Concepts. Kuala Lumpur, University of Malaya, 1983, pp. 423-431.

55. Fisher, R.I., Portlock, C.S., and Longo, D.L.: Hodgkin’s disease. In Golomb, H. (Ed.): Hematology, 1983. San Francisco, American Society of Hematology, 1983, pp. 24-29.

56. Hathcock, K.S., Singer, A., Davis, M., Longo, D., and Hodes, R.J.: The role of polymorphic MHC products in determining the T cell self-recognition repertoire. In Parker, J.W., and O’Brien, R.L. (Eds.): Intercellular Communication in Leucocyte Function. New York, John Wiley & Sons Ltd., 1983, pp. 377-380.

57. Marti, G.E., Folks, T., Longo, D.L., and Klein, H.: Therapeutic cytapheresis in chronic lymphocytic leukemia. J. Clin. Apheresis 1: 243-248, 1983. PMID: 6336269

58. Armstrong, G., Longo, D., Faggioni, A., Ablashi, D., Pearson, G., and Slovin, S.: Detection and isolation of Epstein-Barr virus in lymphocytes from patients with chronic B-lymphocytic leukemia. In Magrath, I.T., O’Connor, G.T., and Ramot, B. (Eds.): Role of Environment in Pathogenesis of Leukemia and Lymphoma. New York, Raven Press, 1984, pp. 259-262.

59. Averbuch, S.D., Austin, H.A., Sherwin, S.A., Antonovych, T., Bunn, P.A., Jr., and Longo, D.L.: Acute interstitial nephritis with the nephrotic syndrome following recombinant leukocyte A interferon therapy for mycosis fungoides. N. Engl. J. Med. 310: 32-35, 1984.
PMID: 6689738

60. Longo, D.L.: Kaposi’s sarcoma and other neoplasms. NIH Combined Clinical Staff Conference. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. A.S. Fauci, moderator. Ann. Intern. Med. 100: 96-98, 1984. PMID: 6318629

61. Berkower, I., Matis, L.A., Buckenmeyer, G.K., Gurd, F.R.N., Longo, D.L., and Berzofsky, J.A.: Identification of distinct predominant epitopes recognized by myoglobin-specific T cells under the control of different Ir genes and characterization of representative T cell clones. J. Immunol. 132: 1370-1378, 1984. PMID: 6198391

62. Potter, D.A., Danforth, D.N., Jr., Macher, A.M., Longo, D.L., Stewart, L., and Masur, H.: Evaluation of abdominal pain in the AIDS patient. Ann. Surg. 199: 332-339, 1984. PMID: 6322708

63. Pizzo, P.A., Commers, J., Cotton, D., Gress, J., Hathorn, J., Hiemenz, J., Longo, D., Marshall, D., and Robichaud, K.J.: Approaching the controversies in antibacterial management of cancer patients. Am. J. Med. 76: 436-449, 1984. PMID: 6367456

64. Mongini, P.K.A., Longo, D.L., and Paul, W.E.: T cell regulation of immunoglobulin class expression in the B cell response to TNP-ficoll: characterization of the T cell responsible for preferential enhancement of the IgG2a response. J. Immunol. 132: 1647-1653, 1984. PMID: 6230389

65. Silver, M.A., Macher, A.M., Reichert, C.M., Levens, D.L., Parrillo, J.E., Longo, D.L., and Roberts, W.C.: Cardiac involvement by Kaposi’s sarcoma in acquired immune deficiency syndrome (AIDS). Am. J. Cardiol. 53: 983-985, 1984. PMID: 6702667

66. Longo, D.L., Young, R.C., Hubbard, S.M., Wesley, M., Fisher, R.I., Jaffe, E., Berard, C., and DeVita, V.T., Jr.: Prolonged initial remission in patients with nodular mixed lymphoma. Ann. Intern. Med. 100: 651-656, 1984. PMID: 6370065

67. Cossman, J., Neckers, L.M., Hsu, S.M., Longo, D., and Jaffe, E.S.: Low-grade lymphomas: expression of developmentally regulated B-cell antigens. Am. J. Pathol. 115: 117-124, 1984. PMID: 6201073

68. Young, R.C., Fisher, R.I., Longo, D.L., and DeVita, V.T., Jr.: Non-Hodgkin’s lymphoma: evolution of the NCI approach to management. In Ogawa, M., Muggia, F.M., and Rozencweig, M. (Eds.): Adriamycin: Its Expanding Role in Cancer Treatment. Amsterdam, Excerpta Medica, 1984, pp. 31-42.

69. Kovacs, J.A., Hiemenz, J.W., Macher, A.M., Stover, D., Murray, H.W., Shelhamer, J., Lane, H.C., Urmacher, C., Honig, C., Longo, D.L., Parker, M.M., Natanson, C., Parrillo, J.E., Fauci, A.S., Pizzo, P.A., and Masur, H.: Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. Ann. Intern. Med. 100: 663-671, 1984. PMID: 6231873

70. Longo, D.L., Gelmann, E.P., Cossman, J., Young, R.A., Gallo, R.C., O’Brien, S.J., and Matis, L.A.: Isolation of HTLV-transformed B-lymphocyte clone from a patient with HTLV-associated adult T-cell leukaemia. Nature 310: 505-506, 1984. PMID: 6087161

71. Kruisbeek, A.M., Davis, M.L., Matis, L.A., and Longo, D.L.: Self-recognition specificity expressed by T cells from nude mice. Absence of detectable Ia-restricted T cells in nude mice that do exhibit self-K/D-restricted T cell responses. J. Exp. Med. 160: 839-857, 1984. PMID: 6206191

72. Helman, L.J., Ozols, R.F., and Longo, D.L.: Thrombocytopenia and extragonadal germ-cell neoplasm. Ann. Intern. Med. 101: 280, 1984. PMID: 6742658

73. Young, R.C., Fisher, R.I., Longo, D.L., Bender, R.A., and DeVita, V.T., Jr.: Activity of the epipodophyllotoxin VP-l6 in diffuse large-cell lymphomas. In Issell, B.F., Muggia, F.M., and Carter, S.K. (Eds.): Etoposide (VP-l6): Current Status and New Developments. New York, Academic Press, 1984, pp. 301-311.

74. Bunn, P.A., Jr., Foon, K.A., Ihde, D.C., Longo, D.L., Eddy, J., Winkler, C.F., Veach, S.R., Zeffren, J., Sherwin, S., and Oldham, R.: Recombinant leukocyte A interferon: An active agent in advanced cutaneous T-cell lymphomas. Ann. Intern. Med. 101: 484-487, 1984. PMID: 6332565

75. Lane, H.C., Masur, H., Longo, D.L., Klein, H.G., Rook, A.H., Quinnan, G.V., Jr., Steis, R.G., Macher, A., Whalen, G., Edgar, L.C., and Fauci, A.S.: Partial immune reconstitution in a patient with the acquired immunodeficiency syndrome. N. Engl. J. Med. 311: 1099-1103, 1984. PMID: 6384784

76. Foon, K.A., Sherwin, S.A., Abrams, P.G., Longo, D.L., Fer, M.F., Stevenson, H.C., Ochs, J.J., Bottino, G.C., Schoenberger, C.S., Zeffren, J., Jaffe, E.S., and Oldham, R.K.: Treatment of advanced non-Hodgkin’s lymphoma with recombinant leukocyte A interferon. N. Engl. J. Med. 311: 1148-1152, 1984. PMID: 6482933

77. Lotze, M.T., Robb, R.J., Frana, L.W., Seipp, C.A., Sharrow, S.S., Longo, D.L., Gelmann, E.P., and Rosenberg, S.A.: Clinical studies with purified human IL-2 in patients with the acquired immunodeficiency syndrome and cancer. In Gottlieb, M.S. and Groopman, J.D. (Eds.): Acquired Immune Deficiency Syndrome. New York, Alan R. Liss, Inc., 1984, pp. 409-423.

78. Palestine, A.G., Rodrigues, M.M., Macher, A.M., Chan, C-C., Lane, H.C., Fauci, A.S., Masur, H., Longo, D., Reichert, C.M., Steis, R., Rook, A.H., and Nussenblatt, R.B.: Ophthalmic involvement in acquired immunodeficiency syndrome. Ophthalmol. 91: 1092-1099, 1984. PMID: 6093020

79. Boccia, R.V., Gelmann, E.P., Baker, C.C., Marti, G., and Longo, D.L.: A hemolytic-uremic syndrome with the acquired immunodeficiency syndrome. Ann. Intern. Med. 101: 716-717, 1984. PMID: 6486607

80. Longo, D.L. and DeVita, V.T.: Lymphoma. In Pinedo, H.M. and Chabner,
B.A. (Eds.): Cancer Chemotherapy Annual 6. Amsterdam, Elsevier Science Publishers B.V., 1984, pp. 232-271.

81. Longo, D.L.: Hodgkin’s disease. In Gams, R.A. (Ed.): Hematology. Miami, American Society of Hematology, 1984, pp. 14-19.

82. Kruisbeek, A.M., Matis, L.A., and Longo, D.L.: Thymic dependence of the class II- restricted T cell repertoire: Role of bone marrow-derived IA-bearing thymic medullary antigen presenting cells. In Cantor, H., Chess, L., and Sercarz, E. (Eds.): Regulation of the Immune System, UCLA Symposium on Molecules and Cellular Biology, New Series, Vol. 18. New York, Alan R. Liss, 1984, pp. 243-251.

83. Longo, D.L. and Broder, S.: Human T-cell leukemia/lymphoma virus (HTLV)- associated adult T-cell leukemia. Medical Grand Rounds 3: 239-249, 1984.

84. Patow, C.A., Steis, R., Longo, D.L., Reichert, C.M., Findlay, P.A., Potter, D., Masur, H., Lane, H.C., Fauci, A.S., and Macher, A.M.: Kaposi’s sarcoma of the head and neck in the acquired immune deficiency syndrome. Otolaryngol. Head Neck Surg. 92: 255-260, 1984. PMID: 6431361

85. Patow, C.A., Stark, T.W., Findlay, P.A., Steis, R., Longo, D.L., Masur, H., and Macher, A.M.: Pharyngeal obstruction by Kaposi’s sarcoma in a homosexual male with the acquired immune deficiency syndrome. Otolaryngol. Head Neck Surg. 92: 713-716, 1984. PMID: 6440093

86. Shelhamer, J.H., Ognibene, F.P., Macher, A.M., Tuazon, C., Steis, R., Longo, D., Kovacs, J.A., Parker, M.M., Natanson, C., Lane, H.C., Fauci, A.S., Parrillo, J.E., and Masur, H.: Persistence of Pneumocystis carinii in lung tissue of acquired immunodeficiency syndrome patients treated for pneumocystis pneumonia. Am. Rev. Respir. Dis. 130: 1161-1165, 1984. PMID: 6334462

87. Preble, O.T., Rook, A.H., Steis, R., Silverman, R.H., Krause, D., Quinnan, G.V., Masur, H., Jacob, J., Longo, D., and Gelmann, E.P.: Interferon-induced 2′-5′ oligoadenylate synthetase during interferon- therapy in homosexual men with Kaposi’s sarcoma: Marked deficiency in biochemical response to interferon in patients with acquired immunodeficiency syndrome. J. Infect. Dis. 152: 457-465, 1985. PMID: 2993441

88. Muraguchi, A., Kehrl, J.H., Longo, D.L., Volkman, D.J., Smith, K.A., and Fauci, A.S.: Interleukin 2 receptors on human B cells. Implications for the role of interleukin 2 in human B cell function. J. Exp. Med. 161: 181-197, 1985. PMID: 2981952

89. Foon, K.A., Bottino, G.C., Abrams, P.G., Fer, M.F., Longo, D.L., Schoenberger, C.S., and Oldham, R.K.: Phase II trial of recombinant leukocyte A interferon in patients with advanced chronic lymphocytic leukemia. Am. J. Med. 78: 216-220, 1985. PMID: 3970047

90. Young, R.C., Fisher, R.I., and Longo, D.L.: NonHodgkin’s disease: Unfavorable lymphomas. In Brain, M.C. and Carbone, P.P. (Eds.): Current Therapy in Hematology-Oncology. Toronto, B.C. Decker, Inc., 1985, pp. 280-284.

91. Lane, H.C., Masur, H., Gelmann, E.P., Longo, D.L., Steis, R.G., Chused, T., Whalen, G., Edgar, L.C., and Fauci, A.S.: Correlation between immunologic function and clinical subpopulations of patients with the acquired immune deficiency syndrome. Am. J. Med. 78: 417-422, 1985. PMID: 3872068

92. Longo, D.L., Steis, R.G., Lane, H.C., Lotze, M.T., Rosenberg, S.A., Preble, O., Masur, H., Rook, A.H., Fauci, A.S., Jacob, J., and Gelmann, E.P.: Malignancies in the AIDS patient: Natural history, treatment strategies, and preliminary results. Ann. N.Y. Acad. Sci. 437: 421-430, 1985. PMID: 6598311

93. Kruisbeek, A.M., Mond, J.J., Fowlkes, B.J., Carmen, J.A., Bridges, S., and Longo, D.L.: Absence of the Lyt-2-, L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function. J. Exp. Med. 161: 1029-1047, 1985. PMID: 3921649

94. Kruisbeek, A.M., Bridges, S., Carmen, J., Longo, D.L., and Mond, J.J.: In vivo treatment of neonatal mice with anti-I-A antibodies interferes with the development of the class I, class II, and M1s-reactive proliferating T cell subset. J. Immunol. 134: 3597-3604, 1985. PMID: 3157756

95. Kruisbeek, A.M., Titus, J.A., Stephany, D.A., Gause, B.L., and Longo, D.L.: In vivo treatment with monoclonal anti-I-A antibodies: disappearance of splenic antigen-presenting cell function concomitant with modulation of splenic cell surface I-A and I-E antigens. J. Immunol. 134: 3605-3614, 1985. PMID: 2580891

96. Hecht, T.T., Longo, D.L., Cossman, J., Bolen, J.B., Hsu, S., Israel, M., and Fisher, R.I.: Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells. J. Immunol. 134: 4231-4236, 1985. PMID: 3157756

97. Matis, L.A., Ruscetti, S.K., Longo, D.L., Jacobson, S., Brown, E.J., Zinn, S., and Kruisbeek, A.M.: Distinct proliferative T cell clonotypes are generated in response to a murine retrovirus-induced syngeneic T cell leukemia: viral gp70 antigen-specific MT4+ clones and Lyt-2+ cytolytic clones which recognize a tumor-specific cell surface antigen. J. Immunol. 135: 703-713, 1985. PMID: 2582053

98. Kruisbeek, A.M. and Longo, D.L.: Acquisition of MHC-restriction specificities: Role of thymic stromal cells. Surv. Immunol. Res. 4: 110-119, 1985. PMID: 3898273

99. Geffen, D.B., Fisher, R.I., Longo, D.L., Young, R.C., and DeVita, V.T., Jr.: Renal involvement in diffuse aggressive lymphomas: results of treatment with combination chemotherapy. J. Clin. Oncol. 3: 646-653, 1985. PMID: 3998781

100. Urba, W.J. and Longo, D.L.: Cytologic, immunologic, and clinical diversity in non-Hodgkin’s lymphoma: therapeutic implications. Semin. Oncol. 12: 250-267, 1985. PMID: 3931224

101. Seifter, E.J., Parker, R.I., Gralnick, H.R., Wesley, M., DeVita, V.T., Jr., Young, R.C., and Longo, D.L.: Abnormal coagulation results in patients with Hodgkin’s disease. Am. J. Med. 78: 942-950, 1985. PMID: 3160235

102. Waldmann, T.A., Longo, D.L., Leonard, W.J., Depper, J.M., Thompson, C.B., Kronke, M., Goldman, C.K., Sharrow, S., Bongiovanni, K., and Greene, W.C.: Interleukin-2 receptor (Tac antigen) expression in HTLV-I-associated adult T cell leukemia. Cancer Res. 45: 4559-4562, 1985. PMID: 2990687

103. Urba, W.J. and Longo, D.L.: Clinical spectrum of human retroviral-induced diseases. Cancer Res. 45: 4637-4643, 1985. PMID: 2990699

104. Jaffe, E.S., Clark, J., Steis, R., Blattner, W., Macher, A.M., Longo, D.L., and Reichert, C.M.: Lymph node pathology of HTLV and HTLV associated neoplasms. Cancer Res. 45: 4662-4664, 1985. PMID: 2990705

105. Raffeld, M., Neckers, L., Longo, D.L., and Cossman, J.: Spontaneous alteration of idiotype in a monoclonal B-cell lymphoma. Escape from detection by anti-idiotype. N. Engl. J. Med. 312: 1653-1658, 1985. PMID: 3923351

106. Longo, D.L., Kruisbeek, A.M., Davis, M.L., and Matis, L.A.: Bone marrow-derived thymic antigen-presenting cells determine self-recognition of Ia-restricted T lymphocytes. Proc. Natl. Acad. Sci. USA 82: 5900-5904, 1985. PMID: 3875854

107. Tomita, S., Ambrus, J.L., Volkman, D.J., Longo, D.L., Mitsuya, H., Reitz, M.S., and Fauci, A.S.: Human T cell leukemia/lymphoma virus I infection and subsequent cloning of normal human B cells. J. Exp. Med. 162: 393-398, 1985. PMID: 2989412

108. Longo, D.L. and DeVita, V.T., Jr.: Lymphomas. In Pinedo, H.M. and Chabner, B.A. (Eds.): Cancer Chemotherapy Annual 7. Amsterdam, Elsevier Science Publishers B.V., 1985, pp. 237-272.

109. Bates, S.E. and Longo, D.L.: Tumor markers: Value and limitations in the management of cancer patients. Cancer Treat. Rev. 12: 163-207, 1985. PMID: 2416441

110. Gelmann, E.P., Preble, O.T., Steis, R., Lane, H.C., Rook, A.H., Wesley, M., Jacob, J., Fauci, A., Masur, H., and Longo, D.: Human lymphoblastoid interferon treatment of Kaposi’s sarcoma in the acquired immune deficiency syndrome: clinical response and prognostic parameters. Am. J. Med. 78: 737-741, 1985. PMID: 3838854

111. Seifter, E.J., Young, R.C., and Longo, D.L.: Deep venous thrombosis during therapy for Hodgkin’s disease. Cancer Treat. Rep. 69: 1011-1013, 1985. PMID: 4028033

112. Pizzo, P.A., Thaler, M., Hathorn, J., Hiemenz, J., Skelton, J., McKnight, J., Rubin, M., Browne, M., Longo, D., Cotton, D., Gress, J., and Marshall, D: New beta-lactam antibiotics in granulocytopenic patients: New options and new questions. Am. J. Med. 79 (suppl. 2A): 75-82, 1985. PMID: 3895922

113. Boccia, R.V., Longo, D.L., Lieber, M.L., Jaffe, E.S., and Fisher R.I.: Multiple recurrences of acute tumor lysis syndrome in an indolent non-Hodgkin’s lymphoma. Cancer 56: 2295-2297, 1985. PMID: 3840408

114. Potter, D., Pass, H.I., Brower, S., Macher, A., Browne, M., Thaler, M., Cotton D., Hathorn J., Wesley, R., Longo, D., Pizzo, P., and Roth, J.A.: Prospective randomized study of open lung biopsy versus empirical antibiotic therapy for acute pneumonitis in nonneutropenic cancer patients. Ann. Thorac. Surg. 40: 422-428, 1985. PMID: 4062396

115. Fisher, R.I., Young, R.C., Longo, D., and DeVita, V.T.: ProMACE-MOPP combination chemotherapy for diffuse lymphomas. Semin. Oncol. 12: 29-32, 1985. PMID: 2579441

116. Fisher, R.I., Bates, S.E., Volkman, D.J., Diehl, V., Hecht, T.T., and Longo, D.L.: Origin and biologic function of Reed-Sternberg cells. In Cavalli, F., Bonadonna, G., and Rozencweig, M. (Eds.): Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Boston, Martinus Nijhoff Publishers, 1985, pp. 17-24.

117. Longo, D.L., Steis, R.G., Masur, H., Lane, H.C., Preble, O., Fauci, A.S., and Gelmann, E.P.: Acquired immune deficiency syndrome (AIDS): Basic findings. In Cavalli, F., Bonadonna, G., and Rozencweig, M. (Eds.): Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Boston, Martinus Nijhoff Publishers, 1985, pp. 245-250.

118. Young, R.C., Longo, D.L., Glatstein, E., Duffey, P.L., Winkler, C.F., Wiernik, P.H., and DeVita, V.T., Jr.: The current status of NCI trials in Hodgkin’s disease. In Cavalli, F., Bonadonna, G., and Rozencweig, M. (Eds.): Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Boston, Martinus Nijhoff Publishers, 1985, pp. 293-298.

119. Fisher, R.I., DeVita, V.T., Jr., Longo, D.L., Ihde, D.C., and Young, R.C.: Treatment of diffuse large cell non-Hodgkin’s lymphomas. In Cavalli, F., Bonadonna, G., and Rozencweig, M. (Eds.): Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Boston, Martinus Nijhoff Publishers, 1985, pp. 465-470.

120. Bunn, P.A., Foon, K.A., Ihde, D.C., Longo, D., Schroff, R., Minna, J.D., Carrasquillo, J., Kennan, A., Larson, S., and Glatstein, E.: Treatment of cutaneous T-cell lymphomas with biologic response modifiers: Recombinant leukocyte A interferon and T101 monoclonal antibody. In Cavalli, F., Bonadonna, G., and Rozencweig, M. (Eds.): Malignant Lymphomas and Hodgkin’s Disease: Experimental and Therapeutic Advances. Boston, Martinus Nijhoff Publishers, 1985, pp. 579-590.

121. Little, C. and Longo, D.L.: Non-Hodgkin’s lymphomas: epidemiology, etiology, pathology, natural history, and disease evolution. In Moossa, A.R., Robson, M.C., and Schimpff, S.C. (Eds.): Comprehensive Textbook of Oncology. Baltimore, Williams and Wilkins, 1986, pp. 574-580.

122. Little, C. and Longo, D.L.: Non-Hodgkin’s lymphoma: diagnosis and management. In Moossa, A.R., Robson, M.C., and Schimpff, S.C. (Eds.): Comprehensive Textbook of Oncology. Baltimore, Williams and Wilkins, 1986, pp. 581-592.

123. Little, C. and Longo, D.L.: Burkitt’s lymphoma. In Moossa, A.R., Robson, M.C., and Schimpff, S.C. (Eds.): Comprehensive Textbook of Oncology. Baltimore, Williams and Wilkins, 1986, pp. 593-597.

124. Browne, M.J., Hubbard, S.M., Longo, D.L., Fisher, R., Wesley, R., Ihde, D.C., Young, R.C., and Pizzo, P.A.: Excess prevalence of Pneumocystis carinii pneumonia in patients treated for lymphoma with combination chemotherapy. Ann. Intern. Med. 104: 338-344, 1986. PMID: 3511821

125. Clark, J.W., and Longo, D.L.: Biological response modifiers. In Wiernik, P.H. (Ed.): Mediguide to Oncology 6: 1-10, 1986.

126. Dmitrovsky, E., Martin, S.E., Krudy, A.G., Chu, E.W., Jaffe, E.S., Longo, D.L., and Young, R.C.: Lymph node aspiration in the management of Hodgkin’s disease. J. Clin. Oncol. 4: 306-310, 1986. PMID: 3950673

127. Pass, H.I., Potter, D., Shelhammer, J., Macher, A., Ognibene, F.P., Longo, D.L., Gelmann, E., Masur, H., and Roth, J.A.: Indications for and diagnostic efficacy of open-lung biopsy in the patient with acquired immunodeficiency syndrome (AIDS). Ann. Thorac. Surg. 41: 307-312, 1986. PMID: 3954503

128. Fisher, R.I., DeVita, V.T., Jr., Longo, D.L., and Young, R.C.: Treatment of diffuse aggressive lymphoma with ProMACE-based combination chemotherapy. In Skarin, A.T. (Ed.): Update on Treatment for Diffuse Large Cell Lymphoma. New York, Park Row Publishers, 1986, pp. 31-35.

129. Urba, W.J. and Longo, D.L.: Primary solid tumors of the heart. In Kapoor, A.S. (Ed.): Cancer and the Heart. New York, Springer Verlag, 1986, pp. 62-75.

130. Kant, J.A., Hubbard, S.M., Longo, D.L., Simon, R.M., DeVita, V.T., Jr., and Jaffe, E.S.: The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin’s disease. J. Clin. Oncol. 4: 284-294, 1986. PMID: 3754003

131. Matis, L.A., Young R.C., and Longo, D.L.: Nodular lymphomas: current concepts. CRC Crit. Rev. Oncol./Hematol. 5: 171-197, 1986. PMID: 3521924

132. Foon, K.A., Nakano, G.M., Koller, C.A., Longo, D.L., and Steis, R.G.: Response to 2′-deoxycoformycin after failure of interferon- in nonsplenectomized patients with hairy cell leukemia. Blood 68: 297-300, 1986. PMID: 3487358

133. Pizzo, P.A., Hathorn, J.W., Hiemenz, J., Browne, M., Commers, J., Cotton, D., Gress, J., Longo, D., Marshall, D., McKnight, J., Rubin, M., Skelton, J., Thaler, M., and Wesley, R.: A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N. Engl. J. Med. 315: 552-558, 1986. PMID: 3526155

134. Longo, D.L., Young, R.C., Wesley, M., Hubbard, S.M., Duffey, P.L., Jaffe, E.S., and DeVita, V.T., Jr.: Twenty years of MOPP therapy for Hodgkin’s disease. J. Clin. Oncol. 4: 1295-1306, 1986. PMID: 3528400

135. Bookman, M.A. and Longo, D.L.: Concomitant illness in patients treated for Hodgkin’s disease. Cancer Treat. Rev. 13: 77-111, 1986. PMID: 3527412

136. Longo, D.L., DeVita, V.T., Jr., and Hubbard, S.M.: Non-Hodgkin’s lymphomas. In Slevin, M.L., and Staquet, M.J. (Eds.): Randomized Trials in Cancer: A Critical Review by Sites. New York, Raven Press, 1986, pp. 91-130.

137. Kruisbeek, A.M. and Longo, D.L.: Treatment of neonatal mice with anti-I-A antibodies: lessons on T cell development. In Brochier, J., Clot, J., and Sany, J. (Eds.): Immune Intervention: Anti-Ia Antibodies in the Treatment of Autoimmune Disease. London, Academic Press, 1986, pp. 51-57.

138. Longo, D.L. and DeVita, V.T., Jr.: Malignant lymphomas. In Pinedo, H.M., and Chabner, B.A. (Eds.): Cancer Chemotherapy Annual 8. Amsterdam, Elsevier Science Publishers B.V., 1986, pp. 262-304.

139. Longo, D.L. and Broder, S.: Plasma cell disorders. In Braunwald, E., Isselbacher, K.J., Petersdorf, R.G., Wilson, J.D., Martin, J.B., and Fauci, A.S. (Eds.): Harrison’s Principles of Internal Medicine, 11th Edition. New York, McGraw-Hill, 1986, pp. 1396-1403.

140. Perez, P., Titus, J.A., Lotze, M.T., Cuttitta, F., Longo, D.L., Groves, E.S., Rabin, H., Durda P.J., and Segal, D.M.: Specific lysis of human tumor cells by T cells coated with anti-T3 cross-linked to anti-tumor antibody. J. Immunol. 137: 2069-2072, 1986. PMID: 2944946

141. Longo, D., Klimo, P., and Korsmeyer, S.J.: Malignant lymphomas. ASCO Educational Booklet, 119-134, 1986.

142. Urba, W.J. and Longo, D.L.: -interferon in the treatment of nodular lymphomas. Semin. Oncol. 13: 40-47, 1986. PMID: 3541218

143. Edington, H., Salwitz, J., Longo, D.L., Roth, J.A., and Pass, H.: Thymic hyperplasia masquerading as recurrent Hodgkin’s disease: Case report and review of the literature. J. Surg. Oncol. 33: 120-123, 1986. PMID: 3762184

144. Simrell, C.R., Boccia, R.V., Longo, D.L., and Jaffe, E.S.: Coexisting Hodgkin’s disease and mycosis fungoides: Immunohistochemical proof of its existence. Arch. Pathol. Lab. Med. 110: 1029-1034, 1986. PMID: 3096258

145. Young, R.C., Fisher, R.I., and Longo, D.L.: NonHodgkin’s disease: Unfavorable lymphomas. In Bayless T.M., Brain M.C., and Cherniack R.M. (Eds.): Current Therapy in Internal Medicine – 2. B.C. Decker Inc., Toronto, Philadelphia, 1987, pp. 386-390.

146. Beckner, S.K. and Longo, D.L.: Media for LAK cell generation. Cancer Treat. Rep. 71: 104, 1987. PMID: 3791265

147. Blayney, D.W., Longo, D.L., Young, R.C., Greene, M.H., Hubbard, S.M., Postal, M.G., Duffey, P.L., and DeVita, V.T., Jr.: Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin’s disease. N. Engl. J. Med. 316: 710-714, 1987. PMID: 3821809

148. Gelmann, E.P., Longo, D., Lane, H.C., Fauci, A.S., Masur, H., Wesley, M., Preble, O.T., Jacob, J., and Steis, R.: Combination chemotherapy of disseminated Kaposi’s sarcoma in patients with the acquired immune deficiency syndrome. Am. J. Med. 82: 456-462, 1987. PMID: 2435150

149. DeVita, V.T., Jr., Longo, D.L., Hubbard, S.M., Young, R.C., and Chabner, B.A.: The lymphomas: Biologic implications of therapy and therapeutic implications of the new biology. In Berard, C.W., Dorfman, R.F., Kaufman, N. (Eds.): Malignant Lymphomas. Baltimore, Williams & Wilkins, 1987, pp. 249-267.

150. Steis, R.G., Foon, K.A., and Longo, D.L.: Current and future uses of recombinant interferon alpha in the treatment of low-grade non-Hodgkin’s lymphoma. Cancer 59: 658-663, 1987. PMID: 10822466

151. Fauci, A.S., Rosenberg, S.A., Sherwin, S.A., Dinarello, C.A., Longo, D.L., and Lane, H.C.: Immunomodulators in clinical medicine. Ann. Intern. Med. 106: 421-433, 1987. PMID: 2433978

152. Longo, D.L.: Biological therapy of cancer. In Fortner, J.G. and Rhoads, J.E. (Eds.): Accomplishments in Cancer Research. Philadelphia, J.B. Lippincott Company, 1987, pp. 233-257.

153. Clark, J.W. and Longo, D.L.: Interferons in cancer therapy. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): 2nd Edition Cancer Principles and Practices of Oncology Updates Vol. 1. Philadelphia, J.B. Lippincott Company, 1987, No. 4, pp. 1-16.

154. Raffeld, M., Wright, J.J., Lipford, E., Cossman, J., Longo, D.L., Bakhshi, A., and Korsmeyer, S.J.: Clonal evolution of t(14;18) follicular lymphomas demonstrated by immunoglobulin genes and the 18q21 major breakpoint region. Cancer Res. 47: 2537-2542, 1987. PMID: 3032407

155. Longo, D.L.: Tumor markers: current status of the quest – introductory overview. Semin. Oncol. 14: 85-88, 1987. PMID: 3589681

156. Bates, S.E. and Longo, D.L.: Use of serum tumor markers in cancer diagnosis and management. Semin. Oncol. 14: 102-138, 1987. PMID: 2438773

157. Gregg, E.O., Bridges, S.H., Youle, R.J., Longo, D.L., Houston, L.L., Glennie, M.J., Stevenson, F.K., and Green, I.: Whole ricin and recombinant ricin a chain idiotype-specific immunotoxins for therapy of the guinea pig L2C B cell leukemia. J. Immunol. 138: 4502-4508, 1987. PMID: 3495593

158. Ashwell, J.D., Longo, D.L., and Bridges, S.H.: T-cell tumor elimination as a result of T-cell receptor-mediated activation. Science 237: 61-64, 1987. PMID: 3037698

159. Giardina, S.L., Evans, S.W., Gandino, L., Robey, F.A., Bonvini, E., Longo, D.L., and Varesio, L.: Generation of a murine monoclonal antibody that detects the fos oncogene product. Anal. Biochem. 161: 109-116, 1987. PMID: 3034094

160. Beckner, S.K., Maluish, A.E., and Longo, D.L.: Lymphokine-activated killer cells: culture conditions for the generation of maximal in vitro cytotoxicity in cells from normal donors. Cancer Res. 47: 5504-5508, 1987. PMID: 3498534

161. Jaffe, E.S., Bookman, M.A., and Longo, D.L.: Lymphocytic lymphoma of intermediate differentiation-mantle zone lymphoma: A distinct subtype of B-cell lymphoma. Hum. Pathol. 18: 877-880, 1987. PMID: 3305305

162. Hamilton, T.C., Ozols, R.F., and Longo, D.L.: Biologic therapy for the treatment of malignant common epithelial tumors of the ovary. Cancer 60: 2054-2063, 1987. PMID: 2443236

163. DeVita, V.T., Jr., Hubbard, S.M., and Longo, D.L.: The chemotherapy of lymphomas: Looking back, moving forward – The Richard and Hinda Rosenthal Foundation Award Lecture. Cancer Res. 47: 5810-5824, 1987. PMID: 3311358

164. Longo, D.L. and Broder, S.: Lymphoproliferative disorders. In Samter, M., Talmadge, D.W., Frank, M.M., Austen, K.F., and Claman, H.N. (Eds.): Immunological Diseases, Fourth Edition. Boston, Little, Brown and Company, 1987, pp. 553-595.

165. Miser, J.S., Kinsella, T.J., Triche, T.J., Steis, R., Tsokos, M., Wesley, R., Horvath, K., Belasco, J., Longo, D.L., Glatstein, E., and Israel, M.A.: Treatment of peripheral neuroepithelioma in children and young adults. J. Clin. Oncol. 5: 1752-1758, 1987. PMID: 3316513

166. Bridges, S.H., Kruisbeek, A.M., and Longo, D.L.: Selective in vivo antitumor effects of monoclonal anti-I-A antibody on B cell lymphoma. J. Immunol. 139: 4242-4249, 1987. PMID: 3500981

167. Lipford, E., Wright, J.J., Urba, W., Whang-Peng, J., Kirsch, I.R., Raffeld, M., Cossman, J., Longo, D.L., Bakhshi, A., and Korsmeyer, S.J.: Refinement of lymphoma cytogenetics by the chromosome 18q21 major breakpoint region. Blood 70: 1816-1823, 1987. PMID: 2823937

168. Longo, D.L. and DeVita, V.T., Jr.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 9. Amsterdam, Elsevier Science Publishers B.V., 1987, pp. 165-199. PMID: 3079402

169. Urba, W.J. and Longo, D.L.: Adoptive cellular therapy. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 9. Amsterdam, Elsevier Science Publishers B.V., 1987, pp. 473-483. PMID: 3079414

170. Urba, W.J., Maluish, A.E., and Longo, D.L.: Strategies for immunological monitoring. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 9. Amsterdam, Elsevier Science Publishers B.V., 1987, pp. 484-501. PMID: 2484328

171. Bulloch, K., Cullen, M.R., Schwartz, R.H., and Longo, D.L.: Innervation of immune tissues. Development of innervation within syngeneic thymus tissue transplanted under the kidney capsule of the nude mouse: A light and ultrastructural microscope study. J. Neurosci. Res. 18: 16-27, 1987. PMID: 3682025

172. Bridges, S.H. and Longo, D.L.: In vivo antitumor effects of anti-I-A antibodies. In David, C.S. (Ed.): H-2 Antigens-Genes, Molecules, Function. Proceedings of a NATO Advanced Research Workshop on Major Histocompatibility Complex–Genes/ Molecules/Function, Bar Harbor, Maine, June 5-9, 1987. New York, Plenum Press, 1987, pp. 691-697.

173. Smith, J.W. and Longo, D.L.: Clinical trials using monoclonal antibodies. In Cerutti, P.A., Nygaard, O.F., and Simic, M.G. (Eds.): Anticarcinogenesis and Radiation Protection. New York, Plenum Press, 1987, pp. 491-497.

174. Clark, J. and Longo, D.: Monoclonal antibody therapy of leukemias and lymphomas. J. Exp. Pathol. 3: 319-327, 1987. PMID: 3331646

175. Longo, D.L. and Hathorn, J.: Current therapy for diffuse large-cell lymphoma. Prog. Hematol. XV: 115-136, 1987. PMID: 3332388

176. Maluish, A.E., Urba, W.J., Longo, D.L., Overton, W.R., Coggin D., Crisp, E.R., Williams, R., Sherwin, S.A., Gordon, K., and Steis, R.G.: The determination of an immunologically active dose of interferon-gamma in patients with melanoma. J. Clin. Oncol. 6: 434-445, 1988. PMID: 3127550

177. Miser, J.S., Kinsella, T.J., Triche, T.J., Tsokos, M., Forquer, R., Wesley, R., Horvath, K., Belasco, J., Longo, D.L., Steis, R., Glatstein, E., and Pizzo, P.A.: Preliminary results of treatment of Ewing’s sarcoma of bone in children and young adults: six months of intensive combined modality therapy without maintenance. J. Clin. Oncol. 6: 484-490, 1988. PMID: 3280743

178. Colamonici, O.R., Ang, S., Quinones, R., Henkart, P., Heikkila, R., Gress, R., Felix, C., Kirsch, I., Longo, D., Marti, G., Seidman, J.G., and Neckers, L.M.: IL-2-dependent expansion of CD3+ large granular lymphocytes expressing T cell receptor-: Evidence for a functional receptor by anti-CD3 activation of cytolysis. J. Immunol. 140: 2527-2533, 1988. PMID: 2965722

179. Whang-Peng, J., Young, R.C., Lee, E.C., Longo, D.L., Schechter, G.P., and DeVita, V.T., Jr.: Cytogenetic studies in patients with secondary leukemia/dysmyelopoietic syndrome after different treatment modalities. Blood 71: 403-414, 1988. PMID: 3337904

180. Steis, R.G. and Longo, D.L.: Clinical, biologic, and therapeutic aspects of malignancies associated with the acquired immunodeficiency syndrome: Part I. Ann. Allergy 60: 310-314, 1988.

181. Steis, R.G. and Longo, D.L.: Clinical, biologic, and therapeutic aspects of malignancies associated with the acquired immunodeficiency syndrome: Part II. Ann. Allergy 60: 315-323, 1988. PMID: 2451890

182. Urba, W.J., Longo, D.L., Lombardo, F.A., and Weiss, R.B.: Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. J. Natl. Cancer Inst. 80: 521-525, 1988. PMID: 2452890

183. Steis, R.G., Marcon, L., Clark, J., Urba, W., Longo, D.L., Nelson, D.L., and Maluish, A.E.: Serum soluble IL-2 receptor as a tumor marker in patients with hairy cell leukemia. Blood 71: 1304-1309, 1988. PMID: 3129046

184. Marusic-Galesic, S., Stephany, D.A., Longo, D.L., and Kruisbeek, A.M.:
Development of CD4-CD8+ cytotoxic T cells requires interactions with class I MHC determinants. Nature 333: 180-183, 1988. PMID: 3259290

185. DeVita, V.T., Jr., Hubbard, S.M., Young, R.C., and Longo, D.L.: The role of chemotherapy in diffuse aggressive lymphomas. Semin. Hematol. 25: 2-10, 1988. PMID: 3041598

186. Young, R.C., Longo, D.L., Glatstein, E., Ihde, D.C., Jaffe, E.S., and
DeVita, V.T., Jr.: The treatment of indolent lymphomas: watchful waiting vs. aggressive combined modality treatment. Semin. Hematol. 25: 11-16, 1988. PMID: 2456618

187. Steis, R.G., Smith, J.W., II, Urba, W.J., Clark, J.W., Itri, L.M., Evans, L.M., Schoenberger, C., and Longo, D.L.: Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies. N. Engl. J. Med. 318: 1409-1413, 1988. PMID: 3367950

188. Steis, R.G., Urba, W.J., Clark, J.W., Smith, J.W., II, Itri, L.M., Evans, L.M., and Longo, D.L.: Immunogenicity of different types of interferons in the treatment of hairy-cell leukemia. N. Engl. J. Med. 319: 1226-1227, 1988.

189. Giardina, S.L., Storm, S.M., Longo, D.L., Mathieson, B.J., Rapp, U., and Varesio, L.: Characterization of a murine monoclonal antibody that detects a c-terminal fragment of the raf oncogene product. J. Immunol. 140: 3528-3533, 1988. PMID: 3361124

190. Urba, W.J. and Longo, D.L.: T cell lymphoma. In Brain, M.C. and Carbone, P.P. (Eds.): Current Therapy in Hematology-Oncology-3. Toronto, B.C. Decker Inc., 1988, pp. 297-302.

191. Steis, R.G. and Longo, D.L.: Update on the treatment of hairy cell leukemia. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): 2nd Edition Cancer Principles and Practice of Oncology Updates, Vol. 2. Philadelphia, J.B. Lippincott Company, 1988, No. 6, pp. 1-12.

192. Marcon, L., Rubin, L.A., Kurman, C.C., Fritz, M.E., Longo, D.L., Uchiyama, T., Edwards, B.K., and Nelson, D.L.: Elevated serum levels of soluble Tac peptide in adult T-cell leukemia: correlation with clinical status during chemotherapy. Ann. Intern. Med. 109: 274-279, 1988. PMID: 2899410

193. Ortaldo, J.R. and Longo, D.L.: Human natural lymphocyte effector cells: Definition, analysis of activity, and clinical effectiveness. J. Natl. Cancer Inst. 80: 999-1010, 1988. PMID: 3045334

194. VanderMolen, L.A., Swain, S., and Longo, D.L.: Lactic acidosis in lymphoma: Prompt resolution of acidosis with therapy directed at the lymphoma. J. Natl. Cancer Inst. 80: 1077-1078, 1988. PMID: 3411621

195. Whang-Peng, J., Lee, E.C., Minna, J.D., Abeloff, M.D., Bradley, E.C., Young, R.C., and Longo, D.L.: Deletion of 3(p14p23) in secondary erythroleukemia arising in long-term survivors of small cell lung cancer. J. Natl. Cancer Inst. 80: 1253-1255, 1988. PMID: 2843653

196. Bookman, M.A., Longo, D.L., and Young, R.C.: Late complications of curative treatment in Hodgkin’s disease. JAMA 260: 680-683, 1988. PMID: 3392794

197. Vukelja, S.J., Weiss, R.B., Perry, D.J., and Longo, D.L.: Eosinophilia associated with adult T-cell leukemia/lymphoma. Cancer 62: 1527-1530, 1988. PMID: 3262407

198. Lipford, E.H., Jr., Margolick, J.B., Longo, D.L., Fauci, A.S., and Jaffe, E.S.: Angiocentric immunoproliferative lesions: A clinicopathologic spectrum of post-thymic T-cell proliferations. Blood 72: 1674-1681, 1988. PMID: 3263153

199. Giardina, S.L., Young, H.A., Faltynek, C.R., Jaffe, E.S., Clark, J.W., Steis, R.G., Urba, W.J., Mathieson, B.J., Gralnick, H., Lawrence, J., Overton, W.R., and Longo, D.L.: Rearrangement of both immunoglobulin and T-cell receptor genes in a prolymphocytic variant of hairy cell leukemia patient resistant to interferon-alpha. Blood 72: 1708-1716, 1988. PMID: 2846090

200. Waldmann, T.A., Goldman, C.K., Bongiovanni, K.F., Sharrow, S.O., Davey, M.P., Cease, K.B., Greenberg, S.J., and Longo, D.L.: Therapy of patients with human T-cell lymphotrophic virus I-induced adult T-cell leukemia with anti-Tac, a monoclonal antibody to the receptor for interleukin-2. Blood 72: 1805-1816, 1988. PMID: 2846094

201. Longo, D.L. and DeVita, Jr., V.T.: Lymphomas. In Pinedo, H.M., Longo,
D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 10. Amsterdam, Elsevier Science Publishers B.V., 1988, pp. 148-181. PMID: 3079382

202. Urba, W.J. and Longo, D.L.: Adoptive cellular therapy. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 10. Amsterdam, Elsevier Science Publishers B.V., 1988, pp. 460-472. PMID: 3079395

203. Tentori, L., Longo, D.L., Zuniga-Pflucker, J.C., Wing, C., and Kruisbeek, A.M.: Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo. J. Exp. Med. 168: 1741-1747, 1988. PMID: 3263466

204. Catane, R. and Longo, D.L.: Monoclonal antibodies for cancer therapy.
Isr. J. Med. Sci. 24: 471-476, 1988. PMID: 3060441

205. Surbone, A., Longo, D.L., DeVita, V.T., Jr., Ihde, D.C., Duffey, P.L., Jaffe, E.S., Solomon, D., Hubbard, S.M., and Young, R.C.: Residual abdominal masses in aggressive non-Hodgkin’s lymphoma after combination chemotherapy: Significance and management. J. Clin. Oncol. 6: 1832-1837, 1988. PMID: 3199167

206. Masuda, A., Longo, D.L., Kobayashi, Y., Appella, E., Oppenheim, J.J., and Matsushima, K.: Induction of mitochondrial manganese superoxide dismutase by interleukin 1. FASEB J. 2: 3087-3091, 1988. PMID: 3263930

207. Kruisbeek, A.M., Zuniga-Pflucker, J., Marusic-Galesic, S., Weston, M.A., Tentori, L., and Longo, D.L.: Thymic selection of the T-cell repertoire. Immunol. Res. 7: 318-328, 1988. PMID: 3147309

208. Matis, L.A., Heckford, S.E., and Longo, D.L.: Influence of bone marrow-derived Ia-bearing cells on the selection of the T-cell repertoire. Immunol. Res. 7: 329-338, 1988. PMID: 3265713

209. Hornung, R.L., Back, T.C., Zaharko, D.S., Urba, W.J., Longo, D.L., and Wiltrout, R.H.: Augmentation of natural killer activity, induction of IFN and development tumor immunity during the successful treatment of established murine renal cancer using flavone acetic acid and IL-2. J. Immunol. 141: 3671-3679, 1988. PMID: 2460546

210. Wilding, G., Greene, H.L., Longo, D.L., and Urba, W.J.: Tumors of the heart and pericardium. Cancer Treat. Rev. 15: 165-181, 1988. PMID: 3061639

211. Clark, J.W. and Longo, D.L.: Adoptive therapies: Quo vadis? Pathol. Immunopathol. Res. 7: 442-458, 1988. PMID: 3070530

212. Steis, R.G., Clark, J., Longo, D.L., Smith, J., Miller, R., Ruscetti, F., Hursey, J., and Urba, W.: A phase Ib evaluation of recombinant human granulocyte-macrophage colony-stimulating factor. In Beger, H.G., Buchler, M., Reisfeld, R.A., and Schulz, G. (Eds.): Cancer Therapy: Monoclonal Antibodies, Lymphokines. Berlin, Springer-Verlag Publishing Co., 1989, pp. 103-111.

213. Urba, W.J., Baseler, M.W., Kopp, W.C., Steis, R.G., Clark, J.W., Smith, J.W., II, Coggin, D.L., and Longo, D.L.: Deoxycoformycin-induced immunosuppression in patients with hairy cell leukemia. Blood 73: 38-46, 1989. PMID: 2783373

214. Longo, D.L. and Urba, W.J.: Hodgkin’s disease. In Kelley, W.N. (Ed.): Textbook of Internal Medicine. Philadelphia, J.B. Lippincott Company, 1989, pp. 1191-1195.

215. Urba, W.J. and Longo, D.L.: Lymphocytic lymphomas. In Kelley, W.N. (Ed.): Textbook of Internal Medicine. Philadelphia, J.B. Lippincott Company, 1989, pp. 1195-1202.

216. Longo, D.L.: Principles of cancer treatment. In Kelley, W.N. (Ed.): Textbook of Internal Medicine. Philadelphia, J.B. Lippincott Company, 1989, pp. 1214-1228.

217. Longo, D.L.: The spleen and its disorders. In Kelley, W.N. (Ed.): Textbook of Internal Medicine. Philadelphia, J.B. Lippincott Company, 1989, pp. 1306-1311.

218. Longo, D.L. and Urba, W.J.: Differential diagnosis of lymphadenopathy and the management of patients with lymphoma. In Kelley, W.N. (Ed.): Textbook of Internal Medicine. Philadelphia, J.B. Lippincott Company, 1989, pp. 1311-1323.

219. Kovacs, E.J., Beckner, S.K., Longo, D.L., Varesio, L., and Young, H.A.: Cytokine gene expression during the generation of human lymphokine-activated killer cells: Early induction of interleukin 1 by interleukin 2. Cancer Res. 49: 940-944, 1989. PMID: 2783560

220. Schiogolev, S.A., Goetzl, E.J., Urba, W.J., and Longo, D.L.: Appearance of neuropeptides in ascitic fluid after peritoneal therapy with interleukin-2 and lymphokine-activated killer cells for intraabdominal malignancy. J. Clin. Immunol. 9: 169-173, 1989. PMID: 2469694

221. Miller, R.L., Steis, R.G., Clark, J.W., Smith, J.W., II, Crum, E., McKnight, J.E., Hawkins, M.J., Jones, M.J., Longo, D.L., and Urba, W.J.: Randomized trial of recombinant 2b-interferon with or without indomethacin in patients with metastatic malignant melanoma. Cancer Res. 49: 1871-1876, 1989. PMID: 2647294

222. Zuniga-Pflucker, J.C., Longo, D.L., and Kruisbeek, A.M.: Positive selection of CD4-CD8+ T cells in the thymus of normal mice. Nature 338: 76-78, 1989. PMID: 2521924

223. Urba, W.J., Clark, J.W., Steis, R.G., Bookman, M.A., Smith, J.W., II, Beckner, S., Maluish, A.E., Rossio, J.L., Rager, H., Ortaldo, J.R., and Longo, D.L.: Intraperitoneal lymphokine-activated killer cell/interleukin-2 therapy in patients with intra-abdominal cancer: Immunologic considerations. J. Natl. Cancer Inst. 81: 602-611, 1989. PMID: 2495368

224. Adachi, M., Cossman, J., Longo, D., Croce, C.M., and Tsujimoto, Y.: Variant translocation of the bcl-2 gene to immunoglobulin  light chain gene in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 86: 2771-2774, 1989. PMID: 2704746

225. Marusic-Galesic, S., Longo, D.L., and Kruisbeek, A.M.: Preferential differentiation of T cell receptor specificities based on the MHC glycoproteins encountered during development: Evidence for positive selection. J. Exp. Med. 169: 1619-1630, 1989. PMID: 2785580

226. Rosenberg, S.A., Longo, D.L., and Lotze, M.T.: Principles and applications of biologic therapy. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Cancer: Principles and Practice of Oncology. Philadelphia, J.B. Lippincott Company, 1989, pp. 301-347.

227. Linehan, W.M., Shipley, W.U., and Longo, D.L.: Cancer of the kidney and ureter. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Cancer: Principles and Practice of Oncology. Philadelphia, J.B. Lippincott Company, 1989, pp. 979-1007.

228. DeVita, V.T., Jr., Jaffe, E.S., Mauch, P., and Longo, D.L.: Lymphocytic lymphomas. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Cancer: Principles and Practice of Oncology. Philadelphia, J.B. Lippincott Company, 1989, pp. 1741-1798.

229. Hartmann, L.C., Urba, W.J., Steis, R.G., Smith, J.W., II, VanderMolen, L., Creekmore, S.P., and Longo, D.L.: Hypothyroidism after interleukin-2 therapy. J. Clin. Oncol. 7: 686-687, 1989. PMID: 2785167

230. Jaffe, E.S., Lipford, E.H., Jr., Margolick, J.B., Longo, D.L., and Fauci, A.S.: Lymphomatoid granulomatosis and angiocentric lymphoma: A spectrum of post-thymic T-cell proliferations. Semin. Resp. Med. 10: 167-172, 1989. PMID: 3263153

231. Talmadge, J.E., Schneider, M., Keller, J., Ruscetti, F., Longo, D., Pennington, R., Bowersox, O., and Tribble, H.: Myelostimulatory activity of recombinant human interleukin-2 in mice. Blood 73: 1458-1467, 1989. PMID: 2785408

232. Zuniga-Pflucker, J.C., McCarthy, S.A., Weston, M., Longo, D.L., Singer, A., and Kruisbeek, A.M.: Role of CD4 in thymocyte selection and maturation. J. Exp. Med. 169: 2085-2096, 1989. PMID: 2525172

233. Clark, J.W. and Longo, D.L.: Biologic response modifiers in cancer therapy. In Magrath, I. (Ed.): New Directions in Cancer Treatment. Geneva, Springer-Verlag Publishers, 1989, pp. 297-316.

234. Longo, D.L.: Hodgkin’s disease. In Magrath, I. (Ed.): New Directions in Cancer Treatment. Geneva, Springer-Verlag Publishers, 1989, 561-565.

235. Urba, W.J. and Longo, D.L.: Diffuse aggressive lymphomas in adults. In Magrath, I. (Ed.): New Directions in Cancer Treatment. Geneva, Springer-Verlag Publishers, 1989, pp. 575-579.

236. Kenny, J.J., Finkelman, F., Macchiarini, F., Kopp, W.C., Storb, U., and Longo, D.L.: Alteration of the B cell surface phenotype, immune response to phosphocholine and the B cell repertoire in M167  plus  transgenic mice. J. Immunol. 142: 4466-4474, 1989. PMID: 2498429

237. Pearson, J.W., FitzGerald, D.J.P., Willingham, M.C., Wiltrout, R.H., Pastan, I., and Longo, D.L.: Chemoimmunotoxin therapy against a human colon tumor (HT-29) xenografted into nude mice. Cancer Res. 49: 3562-3567, 1989. PMID: 2499420

238. Wiltrout, R.H., Pilaro, A.M., Gruys, M.E., Talmadge, J.E., Longo, D.L., Ortaldo, J.R., and Reynolds, C.W.: Augmentation of mouse liver-associated natural killer activity by biologic response modifiers occurs largely via rapid recruitment of large granular lymphocytes from the bone marrow. J. Immunol. 143: 372-378, 1989. PMID: 2732472

239. Goey, H., Keller, J.R., Back, T., Longo, D.L., Ruscetti, F.W., and Wiltrout, R.H.: Inhibition of early murine hemopoietic progenitor cell proliferation after in vivo locoregional administration of transforming growth factor-1. J. Immunol. 143, 877-880, 1989. PMID: 2745976

240. Hartmann, L.C., Urba, W.J., Steis, R.G., Smith, J.W., II, VanderMolen, L. A., Creekmore, S.P., Sznol, M., Casciano, M.A., Engler, N., and Longo, D.L.: Use of prophylactic antibiotics for prevention of intravascular catheter-related infections in interleukin-2-treated patients. J. Natl. Cancer Inst. 81: 1190-1193, 1989. PMID: 2787409

241. VanderMolen, L.A., Smith, J.W., II, Longo, D.L., Steis, R.G., Kremers, P., and Sznol, M.: Adrenal insufficiency and interleukin-2 therapy. Ann. Intern. Med. 111: 185, 1989. PMID: 2787137

242. Longo, D.L.: Combined modality therapy for localized aggressive lymphoma: enough or too much? J. Clin. Oncol. 7: 1179-1181, 1989. PMID: 2769325

243. Longo, D.L., Glatstein, E., Duffey, P.L., Ihde, D.C., Hubbard, S.M., Fisher, R.I., Jaffe, E.S., Gilliom, M., Young, R.C., and DeVita, V.T., Jr.: Treatment of localized aggressive lymphomas with combination chemotherapy followed by involved-field radiation therapy. J. Clin. Oncol. 7: 1295-1302, 1989. PMID: 2788716

244. VanderMolen, L.A., Urba, W.J., Longo, D.L., Lawrence, J., Gralnick, H., and Steis, R.G.: Diffuse osteosclerosis in hairy cell leukemia. Blood 74: 2066-2069, 1989. PMID: 2804348

245. Oppenheim, J.J., Neta, R., Tiberghien, P., Gress, R., Kenny, J.J., and Longo, D.L.: Interleukin-1 enhances survival of lethally irradiated mice treated with allogeneic bone marrow cells. Blood 74: 2257-2263, 1989. PMID: 28043963

246. Pearson, J.W., Sivam, G., Manger, R., Wiltrout, R.H., Morgan, A.C., Jr., and Longo, D.L.: Enhanced therapeutic efficacy of an immunotoxin in combination with chemotherapy against an intraperitoneal human tumor xenograft in athymic mice. Cancer Res. 49: 4990-4995, 1989. PMID: 2504482

247. Bridges, S., Longo, D.L., and Youle, R.J.: Preparation and use of anti-idiotypic antibodies armed with holotoxins or hemitoxins in treatment of B-cell neoplasms. Methods Enzymol. 178: 356-368, 1989. PMID: 2601625

248. Groves, E.S. and Longo, D.L.: Progression of lymphoproliferative disorders and hematologic malignancies. In Brunson, K.W. (Ed.): Local Invasion and Spread of Cancer. Dordrecht, Kluwer Academic Publishers, 1989, pp. 122-147.

249. Zuniga-Pflucker, J.C., Jones, L.A., Longo, D.L., and Kruisbeek, A.M.: Both TCR/MHC and accessory molecule/MHC interactions are required for positive and negative selection of mature T cells in the thymus. Cold Spring Harbor Symp. Quant. Biol. LIV: 153-158, 1989. PMID: 2517918

250. Jones, L.A., Zuniga-Pflucker, J.C., Fine, J.S., Longo, D.L., and Kruisbeek, A.M.: Development of the T cell repertoire: contribution of both TCR-MHC and accessory molecules-MHC interactions. Prog. Immunol. 7: 289-296, 1989.

251. Morgan, A.C., Jr., Manger, R., Pearson, J.W., Longo, D., Abrams, P., Bjorn, M., and Sivam, G.: Holotoxin immunoconjugates of Pseudomonas exotoxin A: evaluation in mice, monkeys, and man. Antibody Immunoconjug. Radiopharmaceut. 2: 165-178, 1989.

252. Kohn, E.C., Steis, R.G., Sausville, E.A., Veach, S.R., Stocker, J.L., Phelps, R., Franco, S., Longo, D.L., Bunn, P.A., and Ihde, D.C.: Phase II trial of intermittent high-dose recombinant interferon alfa-2a in mycosis fungoides and the Sezary syndrome. J. Clin. Oncol. 8: 155-160, 1990. PMID: 2295906

253. Urba, W.J., Steis, R.G., Longo, D.L., Kopp, W.C., Maluish, A.E., Marcon, L., Nelson, D.L., Stevenson, H.C., and Clark, J.W.: Immunomodulatory properties and toxicity of interleukin 2 in patients with cancer. Cancer Res. 50: 185-192, 1990. PMID: 2293554

254. Longo, D.L. and Wilson, W.: Follicular lymphomas. In Magrath, I.T. (Ed.): Non-Hodgkin’s Lymphoma. London, Edward Arnold Ltd., 1990, pp. 293-308.

255. VanderMolen, L.A., Steis, R.G., Duffey, P.L., Foon, K.A., Smith, J.W., II, Clark, J.W., Conlon, K., Stevenson, H.C., Urba, W.J., Hartmann, L.C., Watson, T., Jaffe E.S., and Longo, D.L.: Low- versus high-dose interferon alfa-2a in relapsed indolent non-Hodgkin’s lymphoma. J. Natl. Cancer Inst. 82: 235-238, 1990. PMID: 2296053

256. Steis, R.G., Carrasquillo, J.A., McCabe, R., Bookman, M.A., Reynolds, J.C., Larson, S.M., Smith, J.W., II, Clark, J.W., Dailey, V., Del Vecchio, S., Shuke, N., Pinsky, C.M., Urba, W.J., Haspel, M., Perentesis, P., Paris, B., Longo, D.L., and Hanna, M.G., Jr.: Toxicity, immunogenicity, and tumor radioimmunodetecting ability of two human monoclonal antibodies in patients with metastatic colorectal carcinoma. J. Clin. Oncol. 8: 476-490, 1990. PMID: 1689772

257. Bridges, S.H. and Longo, D.L.: T cell tumor cure by T cell receptor-mediated activation requires the development of CD8-dependent host immunity. J. Immunol. 144: 2010-2017, 1990. PMID: 2155271

258. Zuniga-Pflucker, J.C., Jones, L.A., Longo, D.L., and Kruisbeek, A.M.: CD8 is required during positive selection of CD4-/CD8+ T cells. J. Exp. Med. 171: 427-437, 1990. PMID: 1968084

259. Beckwith, M., Longo, D.L., O’Connell, C.D., Moratz, C.M., and Urba, W.J.: Phorbol ester-induced, cell-cycle-specific, growth inhibition of human B-lymphoma cell lines. J. Natl. Cancer Inst. 82: 501-509, 1990. PMID: 2313723

260. Martin, A., Nerenstone, S., Urba, W.J., Longo, D.L., Lawrence, J.B., Clark, J.W., Hawkins, M.J., Creekmore, S.P., Smith, J.W., II, and Steis, R.G.: Treatment of hairy cell leukemia with alternating cycles of pentostatin and recombinant leukocyte A interferon: results of a phase II study. J. Clin. Oncol. 8: 721-730, 1990. PMID: 2313337

261. DeVita, V.T., Jr., Hubbard, S.M., and Longo, D.L.: Treatment of Hodgkin’s disease. J. Natl. Cancer Inst. Monogr. 10: 19-28, 1990. PMID: 2189473

262. Urba, W.J., Duffey, P.L., and Longo, D.L.: Treatment of patients with aggressive lymphomas: an overview. J. Natl. Cancer Inst. Monogr. 10: 29-37, 1990. PMID: 2189474

263. Young, R.C., Bookman, M.A., and Longo, D.L.: Late complications of Hodgkin’s disease management. J. Natl. Cancer Inst. Monogr. 10: 55-60, 1990. PMID: 2189477

264. Steis, R.G., VanderMolen, L.A., Longo, D.L., Clark, J.W., Smith, J.W., II, Kopp, W.C., Ruscetti, F.W., Creekmore, S.P., Elwood, L.J., Hursey, J., and Urba, W.J.: Recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy: A phase Ib trial. J. Natl. Cancer Inst. 82: 697-703, 1990. PMID: 2138680

265. Espinoza-Delgado, I., Ortaldo, J.R., Winkler-Pickett, R., Sugamura, K., Varesio, L., and Longo, D.L.: Expression and role of p75 interleukin 2 receptor on human monocytes. J. Exp. Med. 171: 1821-1826, 1990. PMID: 2110244

266. VanderMolen, L.A., Duffey, P.L., Cossman, J., Jaffe, E.S., and Longo, D.L.: Surface light chain phenotype in indolent lymphomas: Lack of prognostic significance. Am. J. Hematol. 34: 15-20, 1990. PMID: 2109529

267. Urba, W.J., Hartmann, L.C., Longo, D.L., Steis, R.G., Smith, J.W., II, Kedar, I., Creekmore, S., Sznol, M., Conlon, K., Kopp, W.C., Huber, C., Herold, M., Alvord, W.G., Snow, S., and Clark, J.W.: Phase I and immunomodulatory study of a muramyl peptide, muramyl tripeptide phosphatidylethanolamine. Cancer Res. 50: 2979-2986, 1990. PMID: 1692252

268. Bookman, M.A., Lardelli, P., Jaffe, E.S., Duffey, P.L., and Longo, D.L.: Lymphocytic lymphoma of intermediate differentiation: morphologic, immunophenotypic, and prognostic factors. J. Natl. Cancer Inst. 82: 742-748, 1990. PMID: 2182891

269. Aiello, F.B., Longo, D.L., Overton, R., Takacs, L., and Durum, S.K.: A role for cytokines in antigen presentation: IL-1 and IL-4 induce accessory functions of antigen-presenting cells. J. Immunol. 144: 2572-2581, 1990. PMID: 2108207

270. Conlon, K.C., Urba, W.J., Smith, J.W., II, Steis, R.G., Longo, D.L., and Clark, J.W.: Exacerbation of symptoms of autoimmune disease in patients receiving alpha-interferon therapy. Cancer 65: 2237-2242, 1990. PMID: 2346907

271. Steis, R.G., VanderMolen, L.A., Lawrence, J., Sing, G., Ruscetti, F., Smith, J.W., II, Urba, W.J., Clark, J., and Longo, D.L.: Erythrocytosis in hairy cell leukaemia following therapy with interferon alpha. Br. J. Haematol. 75: 133-135, 1990. PMID: 2375913

272. Longo, D.L.: Chemotherapy for advanced aggressive lymphoma: more is better…isn’t it? J. Clin. Oncol. 8: 952-955, 1990. PMID: 2189956

273. Blayney, D.W. and Longo, D.L.: Leukemia after treatment of ovarian cancer or Hodgkin’s disease. N. Engl. J. Med. 322: 1818, 1990.

274. Espinoza-Delgado, I., Longo, D.L., Gusella, G.L., and Varesio, L.: IL-2 enhances c-fms expression in human monocytes. J. Immunol. 145: 1137-1143, 1990. PMID: 2143208

275. Lardelli, P., Bookman, M.A., Sundeen, J., Longo, D.L., and Jaffe, E.S.: Lymphocytic lymphoma of intermediate differentiation: morphologic and immunophenotypic spectrum and clinical correlations. Am. J. Surg. Pathol. 14: 752-763, 1990. PMID: 2198813

276. Urba, W.J. and Longo, D.L.: Adoptive cellular therapy. In Pinedo, H.M., Chabner, B.A., and Longo, D.L., (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 11. Amsterdam, Elsevier Science Publishers B.V., 1990, pp. 265-280. PMID: 2223395

277. Longo, D.L. and DeVita, V.T., Jr.: Lymphomas. In Pinedo, H.M., Chabner, B.A., and Longo, D.L., (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 11. Amsterdam, Elsevier Science Publishers B.V., 1990, pp. 343-378. PMID: 2223399

278. Zuniga-Pflucker, J.C., Smith, K.A., Tentori, L., Pardoll, D.M., Longo, D.L., and Kruisbeek, A.M.: Are the IL-2 receptors expressed in the murine fetal thymus functional? Dev. Immunol. 1: 59-66, 1990. PMID: 2136206

279. Longo, D.L., and Hartmann, L.C.: Biological response modifiers in the management of patients with breast cancer. Breast Cancer Res. Treat. 16: 67-87, 1990. PMID: 2265261

280. Clark, J.W., Smith, J.W., II, Steis, R.G., Urba, W.J., Crum, E., Miller, R., McKnight, J., Beman, J., Stevenson, H.C., Creekmore, S., Stewart, M., Conlon, K., Sznol, M., Kremers, P., Cohen, P., and Longo, D.L.: Interleukin 2 and lymphokine-activated killer cell therapy: analysis of a bolus interleukin 2 and a continuous infusion interleukin 2 regimen. Cancer Res. 50: 7343-7350, 1990. PMID: 2224862

281. Steis, R.G., Urba, W.J., VanderMolen, L.A., Bookman, M.A., Smith, J.W. II, Clark, J.W., Miller, R.L., Crum, E.D., Beckner, S.K., McKnight, J.E., Ozols, R.F., Stevenson, H.C., Young, R.C., and Longo, D.L.: Intraperitoneal lymphokine-activated killer-cell and interleukin-2 therapy for malignancies limited to the peritoneal cavity. J. Clin. Oncol. 8: 1618-1629, 1990. PMID: 2213099

282. Tiberghien, P., Longo, D.L., Wine, J.W., Alvord, W.G., and Reynolds, C.W.: Anti-asialo GM1 antiserum treatment of lethally irradiated recipients before bone marrow transplantation: evidence that recipient natural killer depletion enhances survival, engraftment, and hematopoietic recovery. Blood 76: 1419-1430, 1990. PMID: 2207317

283. Pearson, J.W., Hedrick, E., Fogler, W.E., Bull, R.L., Ferris, D.K., Riggs, C.W., Wiltrout, R.H., Sivam, G., Morgan, A.C., Groves, E., and Longo, D.L.: Enhanced therapeutic efficacy against an ovarian tumor xenograft of immunotoxins used in conjunction with recombinant -interferon. Cancer Res. 50: 6379-6388, 1990. PMID: 2144790

284. Lane, H.C., Zunich, K.M., Wilson, W., Cefali, F., Easter, M., Kovacs, J.A., Masur, H., Leitman, S.F., Klein, H.G., Steis, R.G., Longo, D.L., and Fauci, A.S.: Syngeneic bone marrow transplantation and adoptive transfer of peripheral blood lymphocytes combined with zidovudine in human immunodeficiency virus (HIV) infection. Ann. Intern. Med. 113: 512-519, 1990. PMID: 1975487

285. Sing, G.K., Ruscetti, F.W., Beckwith, M., Keller, J.R., Ellingsworth, L., Urba, W.J., and Longo, D.L.: Growth inhibition of a human lymphoma cell line: induction of a transforming growth factor--mediated autocrine negative loop by phorbol myristate acetate. Cell Growth Differ. 1: 549-557, 1990. PMID: 1965139

286. Longo, D.L.: The use of chemotherapy in the treatment of Hodgkin’s disease. Semin. Oncol. 17: 716-735, 1990. PMID: 2251518

287. Musso, T., Espinoza-Delgado, I., Pulkki, K., Gusella, G.L., Longo, D.L., and Varesio, L.: Transforming growth factor- downregulates interleukin-1 (IL-1)-induced IL-6 production by human monocytes. Blood 76: 2466-2469, 1990. PMID: 2265243

288. Futami, H., Jansen, R., MacPhee, M.J., Keller, J., McCormick, K., Longo, D.L., Oppenheim, J.J., Ruscetti, F.W., and Wiltrout, R.H.: Chemoprotective effects of recombinant human IL-1 in cyclophosphamide-treated normal and tumor-bearing mice: protection from acute toxicity, hematologic effects, development of late mortality and enhanced therapeutic efficacy. J. Immunol. 145: 4121-4130, 1990. PMID: 2258610

289. Creekmore, S.P., Longo, D.L., and Urba, W.J.: The development of regimens for combination immunotherapy. In Rees, R.C. (Ed.): The Biology and Clinical Applications of Interleukin-2. Oxford, IRL Press, 1990, pp. 98-110.

290. DeVita, V.T., Jr., Longo, D.L., Glatstein, E., Duffey, P.L., Hubbard, S.M., Wiernik, P.H., and Young, R.C.: A randomized comparison of radiotherapy versus primary treatment with MOPP chemotherapy in early stage Hodgkin’s disease. In Salmon, S.E. (Ed.): Adjuvant Therapy of Cancer VI. Orlando, W.B. Saunders Company, 1990, pp. 601-609.

291. Jones, L.A., Chin, L.T., Longo, D.L., and Kruisbeek, A.M.: Peripheral clonal elimination of functional T cells. Science 250: 1726-1729, 1990. PMID: 2125368

292. Longo, D.L.: Plasma cell disorders. In Wilson, J.D., Braunwald, E., Fauci, A.S., Isselbacher, K.J., Martin, J.B., Petersdorf, R.G., and Root, R.K. (Eds.): Harrison’s Principles of Internal Medicine, 12th Edition. New York, McGraw-Hill Book Company, 1991, pp. 1410-1417.

293. Smith, J.W., II and Longo, D.L.: The cancer patient. In Parrillo, J.E. (Ed.): Current Therapy in Critical Care Medicine, Second Edition. Ontario, B.C. Decker Inc., 1991, pp. 296-301.

294. Longo, D.L., DeVita, V.T., Jr., Duffey, P.L., Wesley, M.N., Ihde, D.C., Hubbard, S.M., Gilliom, M., Jaffe, E.S., Cossman, J., Fisher, R.I., and Young, R.C.: Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial. J. Clin. Oncol. 9: 25-38, 1991. PMID: 1702144

295. Longo, D.L., Russo, A., Duffey, P.L., Hubbard, S.M., Glatstein, E., Hill, J.B., Jaffe, E.S., Young, R.C., and DeVita, V.T., Jr.: Treatment of advanced-stage massive mediastinal Hodgkin’s disease: the case for combined modality treatment. J. Clin. Oncol. 9: 227-235, 1991. PMID: 1988570

296. Rudnick, S., Stevenson, G.W., Hall, S.C., Espinoza-Delgado, I., Stevenson, H.C., and Longo, D.L.: Halothane potentiates the antitumor activity of gamma-interferon and mimics calmodulin-blocking agents. Anesthesiol. 74: 115-119, 1991. PMID: 1898840

297. Urba, W.J. and Longo, D.L.: Lymphocytic lymphomas: epidemiology, etiology, pathology and staging. In Moossa, A.R., Schimpff, S.C., and Robson, M.C. (Eds.): Comprehensive Textbook of Oncology, Second Edition. Baltimore, Williams & Wilkins, 1991, pp. 1268-1276.

298. Urba, W.J. and Longo, D.L.: Lymphocytic lymphomas: clinical course and management. In Moossa, A.R., Schimpff, S.C., and Robson, M.C. (Eds.): Comprehensive Textbook of Oncology, Second Edition. Baltimore, Williams & Wilkins, 1991, pp. 1277-1295.

299. Urba, W.J. and Longo, D.L.: Burkitt’s lymphoma. In Moossa, A.R., Schimpff, S.C., and Robson, M.C. (Eds.): Comprehensive Textbook of Oncology, Second Edition. Baltimore, Williams & Wilkins, 1991, pp. 1296-1301.

300. Fisher, R.I., Longo, D.L., DeVita, V.T., Jr., Hubbard, S.M., Miller, T.P., and Young, R.C.: Long-term follow-up of ProMACE-CytaBOM in non-Hodgkin’s lymphomas. Ann. Oncol. 2: 33-35, 1991. PMID: 1710487

301. Kantor, R.R.S., Giardina, S.L., Bartolazzi, A., Townsend, A.J., Myers, C.E., Cowan, K.H., Longo, D.L., and Natali, P.G.: Monoclonal antibodies to glutathione S-transferase -immunohistochemical analysis of human tissues and cancers. Int. J. Cancer 47: 193-201, 1991. PMID: 1703126

302. Steis, R.G., Smith, J.W., II, Urba, W.J., Venzon, D.J., Longo, D.L., Barney, R., Evans, L.M., Itri, L.M., and Ewel, C.H.: Loss of interferon antibodies during prolonged continuous interferon-2a therapy in hairy cell leukemia. Blood 77: 792-798, 1991. PMID: 1704264

303. Jin, F-S., Youle, R.J., Johnson, V.G., Shiloach, J., Fass, R., Longo, D.L., and Bridges, S.H.: Suppression of the immune response to immunotoxins with anti-CD4 monoclonal antibodies. J. Immunol. 146: 1806-1811, 1991. PMID: 1672333

304. Kenny, J.J., Stall, A.M., Sieckmann, D.G., Lamers, M.C., Finkelman, F.D., Finch, L., and Longo, D.L.: Receptor-mediated elimination of phosphocholine-specific B cells in x-linked immune deficient mice. J. Immunol. 146: 2568-2577, 1991. PMID: 1901880

305. Loeffler, C.M., Platt, J.L., Anderson, P.M., Katsanis, E., Ochoa, J.B., Urba, W.J., Longo, D.L., Leonard, A.S., and Ochoa, A.C.: Antitumor effects of interleukin 2 liposomes and anti-CD3-stimulated T-cells against murine MCA-38 hepatic metastasis. Cancer Res. 51: 2127-2132, 1991. PMID: 1826232

306. Urba, W.J. and Longo, D.L.: T-cell lymphoma. In Kassirer, J.P. (Ed.): Current Therapy of Internal Medicine, Third Edition. Philadelphia, B.C. Decker, 1991, pp. 913-919.

307. Geller, R.L., Smyth, M.J., Strobl, S.L., Bach, F.H., Ruscetti, F.W., Longo, D.L., and Ochoa, A.C.: Generation of lymphokine-activated killer activity in T cells: possible regulatory circuits. J. Immunol. 146: 3280-3288, 1991. PMID: 1673980

308. Ortaldo, J.R., Mason, A.T., O’Shea, J.J., Smyth, M.J., Falk, L.A., Kennedy, I.C.S., Longo, D.L., and Ruscetti, F.W.: Mechanistic studies of transforming growth factor- inhibition of IL-2-dependent activation of CD3- large granular lymphocyte functions: regulation of IL-2R (p75) signal transduction. J. Immunol. 146: 3791-3798, 1991. PMID: 1851793

309. Walsh, T.J., Rubin, M., Hathorn, J., Gress, J., Thaler, M., Skelton, J., McKnight, J., Browne, M., Marshall, D., Cotton, D., Hiemenz, J., Longo, D., Wesley, R., and Pizzo, P.A.: Amphotericin B vs high-dose ketoconazole for empirical antifungal therapy among febrile, granulocytopenic cancer patients. Arch. Intern. Med. 151: 765-770, 1991. PMID: 2012462

310. Ruscetti, F.W., Dubois, C., Falk, L.A., Jacobsen, S.E., Sing, G., Longo, D.L., Wiltrout, R.H., and Keller, J.R.: In vivo and in vitro effects of TGF-1 on normal and neoplastic haemopoiesis. In Sporn, M.B. (Ed.): Clinical Applications of TGF-. Chichester, John Wiley & Sons, 1991, pp. 212-231. PMID: 1649034

311. Longo, D.L., Glatstein, E., Duffey, P.L., Young, R.C., Hubbard, S.M., Urba, W.J., Wesley, M.N., Raubitschek, A., Jaffe, E.S., Wiernik, P.H., and DeVita, Jr., V.T.: Radiation therapy versus combination chemotherapy in the treatment of early-stage Hodgkin’s disease: seven-year results of a prospective randomized trial. J. Clin. Oncol. 9: 906-917, 1991. PMID: 2033427

312. Creekmore, S.P., Urba, W.J., and Longo, D.L.: Principles of the clinical evaluation of biologic agents. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Biologic Therapy of Cancer. Philadelphia, J.B. Lippincott, 1991, pp. 67-86.

313. Longo, D.L. and DeVita, Jr., V.T.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 12. Amsterdam, Elsevier Science Publishers B.V., 1991, pp. 347-393. PMID: 1931450

314. Hestdal, K., Ruscetti, F.W., Ihle, J.N., Jacobsen, S.E.W., Dubois, C.M., Kopp, W.C., Longo, D.L., and Keller, J.R.: Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells. J. Immunol. 147: 22-28, 1991. PMID: 1711076

315. Smith, J.W., II, Urba, W.J., Steis, R.G., Sznol, M., Creekmore, S.P., and Longo, D.L.: Clinical trials of selected interleukins: the Biological Response Modifiers Program experience. In Baxter, A. and Ross, R. (Eds.): Cytokine Interactions and Their Control. Sussex, John Wiley & Sons Ltd., 1991, pp. 177-194.

316. Ferris, D.K., White, G.A., Kelvin, D.J., Copeland, T.D., Li, C-C.H., and Longo, D.L.: p34cdc2 is physically associated with and phosphorylated by a cdc2-specific tyrosine kinase. Cell Growth Differ. 2: 343-349, 1991. PMID: 1664235

317. Medeiros, L.J., Lardelli, P., Stetler-Stevenson, M., Longo, D.L., and Jaffe, E.S.: Genotypic analysis of diffuse, mixed cell lymphomas. Comparison with morphologic and immunophenotypic findings. Am. J. Clin. Pathol. 95: 547-555, 1991. PMID: 2014781

318. Longo, D.L., Duffey, P.L., DeVita, V.T., Jr., Wiernik, P.H., Hubbard, S.M., Phares, J.C., Bastian, A.W., Jaffe, E.S., and Young, R.C.: Treatment of advanced-stage Hodgkin’s disease: alternating non-crossresistant MOPP/CABS is not superior to MOPP. J. Clin. Oncol. 9: 1409-1420, 1991. PMID: 1712836

319. Longo, D.L. and Urba, W.J.: Hodgkin’s disease. In Kelley, W.N. (Ed.): Textbook of Internal Medicine, Second Edition. Philadelphia, J.B. Lippincott Company, 1991, pp. 1092-1096.

320. Urba, W.J. and Longo, D.L.: Lymphocytic lymphomas. In Kelley, W.N. (Ed.): Textbook of Internal Medicine, Second Edition. Philadelphia, J.B. Lippincott Company, 1991, pp. 1096-1102.

321. Longo, D.L. and Urba, W.J.: Principles of cancer treatment. In Kelley, W.N. (Ed.): Textbook of Internal Medicine, Second Edition. Philadelphia, J.B. Lippincott Company, 1991, pp. 1113-1126.

322. Longo, D.L. and Urba, W.J.: Approach to the management of disorders of the spleen. In Kelley, W.N. (Ed.): Textbook of Internal Medicine, Second Edition. Philadelphia, J.B. Lippincott Company, 1991, pp. 1185-1189.

323. Longo, D.L. and Urba, W.J.: Differential diagnosis of lymphadenopathy and approach to the management of lymphomas. In Kelley, W.N. (Ed.): Textbook of Internal Medicine, Second Edition. Philadelphia, J.B. Lippincott Company, 1991, pp. 1189-1200.

324. Longo, D.L., Duffey, P.L., DeVita, V.T., Jr., Wesley, M.N., Hubbard, S.M., and Young, R.C.: The calculation of actual or received dose intensity: a comparison of published methods. J. Clin. Oncol. 9: 2042-2051, 1991. PMID: 1941063

325. Longo, D.L.: Biologic agents and approaches in the management of patients with lymphoma: a critical appraisal. Hematol./Oncol. Clin. North Am. 5: 1067-1087, 1991. PMID: 1718939

326. Pearson, J.W., Fogler, W.E., Volker, K., Usui, N., Goldenberg, S.K., Gruys, E., Riggs, C.W., Komschlies, K., Wiltrout, R.H., Tsuruo, T., Pastan, I., Gottesman, M.M., and Longo, D.L.: Reversal of drug resistance in a human colon cancer xenograft expressing MDR1 complementary DNA by in vivo administration of MRK-16 monoclonal antibody. J. Natl. Cancer Inst. 83: 1386-1391, 1991. PMID: 1681110

327. Hubbard, S.M. and Longo, D.L.: Treatment-related morbidity in patients with lymphoma. Curr. Opin. Oncol. 3: 852-862, 1991. PMID: 1751579

328. Smith, J.W., II, Urba, W.J., Clark, J.W., Longo, D.L., Farrell, M., Creekmore, S.P., Conlon, K.C., Jaffe, H., and Steis, R.G.: Phase I evaluation of recombinant tumor necrosis factor given in combination with recombinant interferon-gamma. J. Immunother. 10: 355-362, 1991. PMID: 1790143

329. Beckwith, M., Urba, W.J., Ferris, D.K., Freter, C.E., Kuhns, D.B., Moratz, C.M., and Longo, D.L.: Anti-IgM-mediated growth inhibition of a human B lymphoma cell line is independent of phosphatidylinositol turnover and protein kinase C activation and involves tyrosine phosphorylation. J. Immunol. 147: 2411-2418, 1991. PMID: 1918971

330. Smith, J.W., II, Longo, D.L., Urba, W.J., Clark, J.W., Watson, T., Beveridge, J., Conlon, K.C., Sznol, M., Creekmore, S.P., Alvord, W.G., Lawrence, J.B., and Steis, R.G.: Prolonged, continuous treatment of hairy cell leukemia patients with recombinant interferon-2a. Blood 78: 1664-1671, 1991. PMID: 1912555

331. Johnston, P.G., Ruscetti, F.W., Connaghan, D.G., Sullivan, F.J., and Longo, D.L.: Transient reversal of bone marrow aplasia associated with lymphocyte depleted Hodgkin’s disease after combination chemotherapy. Am. J. Hematol. 38: 54-60, 1991. PMID: 1897515

332. Urba, W.J., Kopp, W.C., Clark, J.W., Smith, J.W., II, Steis, R.G., Huber, C., Coggin, D., and Longo, D.L.: The in vivo immunomodulatory effects of recombinant interferon gamma plus recombinant tumor necrosis factor-alfa. J. Clin. Oncol. 9: 1831-1839, 1991. PMID: 1919633

333. Richardson, G.E. and Longo, D.L.: Multiple cavitating pulmonary nodules in Hodgkin’s disease. Cancer 68: 930-933, 1991. PMID: 1913488

334. Tura, S., Canellos, G., Goldstone, A., Longo, D., McMillan, A., Urba, W., and Zinzani, P.L.: Hodgkin’s disease: controversies and challenges for the future. Haematologica 76: 263-279, 1991. PMID: 1724436

335. Longo, D.L.: Editorial: Series on growth factors. Cancer Invest. 9: 321-323, 1991. PMID: 1913234

336. Kenny, J.J., O’Connell, C., Sieckmann, D.G., Fischer, R.T., and Longo, D.L.: Selection of antigen-specific, idiotype-positive B cells in transgenic mice expressing a rearranged M167- heavy chain gene. J. Exp. Med. 174: 1189-1201, 1991. PMID: 1940797

337. Jacobsen, S.E.W., Ruscetti, F.W., Longo, D.L., and Keller, J.R.: Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells. J. Natl. Cancer Inst. 83: 1672-1677, 1991. PMID: 1749020

338. Steis, R.G., Urba, W.J., Kopp, W.C., Alvord, W.G., Smith, J.W., II, and Longo, D.L.: Kinetics of recovery of CD4+ T cells in the peripheral blood of deoxycoformycin-treated patients. J. Natl. Cancer Inst. 83: 1678-1679, 1991. PMID: 1684207

339. Jansen, R., Damia, G., Usui, N., Keller, J., Futami, H., Goey, H., Back, T.T., Longo, D.L., Ruscetti, F.W., and Wiltrout, R.H.: Effects of recombinant transforming growth factor-1 on hematologic recovery after treatment of mice with 5-fluorouracil. J. Immunol. 147: 3342-3347, 1991. PMID: 1940339

340. Armitage, J.O. and Longo, D.L.: Hodgkin’s and non-Hodgkin’s malignant lymphomas: management options. In Schafer, A.I. and McArthur, J.R. (Eds.): Hematology, 1991. Denver, American Society of Hematology, 1991, pp. 22-30.

341. Pai, L.H., Bookman, M.A., Ozols, R.F., Young, R.C., Smith, J.W., II, Longo, D.L., Gould, B., Frankel, A., McClay, E.F., Howell, S., Reed, E., Willingham, M.C., FitzGerald, D.J., and Pastan, I.: Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer. J. Clin. Oncol. 9: 2095-2103, 1991. PMID: 1960550

342. Janik, J.E. and Longo, D.L.: Biological response modifiers in breast cancer. Comprehensive Therapy 17: 28-31, 1991. PMID: 1790662

343. Morgan, A.C., Jr., Manger, R., Pearson, J.W., Longo, D., Abrams, P., Sivam, G., and Bjorn, M.: Immunoconjugates of Pseudomonas exotoxin A: evaluation in mice, monkeys, and man. Cancer Detect. Prev. 15: 137-143, 1991. PMID: 2032255

344. Hornung, R.L., Pearson, J.W., Beckwith, M., and Longo, D.L.: Preclinical evaluation of bryostatin as an anticancer agent against several murine tumor cell lines: in vitro versus in vivo activity. Cancer Res. 52: 101-107, 1992. PMID: 1727368

345. O’Connor, P.M., Ferris, D.K., White, G.A., Pines, J., Hunter, T., Longo, D.L., and Kohn, K.W.: Relationships between cdc2 kinase, DNA cross-linking and cell cycle perturbations induced by nitrogen mustard. Cell Growth Differ. 3: 43-52, 1992. PMID: 1534688

346. Musso, T., Espinoza-Delgado, I., Pulkki, K., Gusella, G.L., Longo, D.L., and Varesio, L.: IL-2 induces IL-6 production in human monocytes. J. Immunol. 148: 795-800, 1992. PMID: 1730872

347. Longo, D.L., Duffey, P.L., Young, R.C., Hubbard, S.M., Ihde, D.C., Glatstein, E., Phares, J.C., Jaffe, E.S., Urba, W.J., and DeVita, V.T., Jr.: Conventional-dose salvage combination chemotherapy in patients relapsing with Hodgkin’s disease after combination chemotherapy: the low probability for cure. J. Clin. Oncol. 10: 210-218, 1992. PMID: 1732422

348. Sundeen, J.T., Longo, D.L., and Jaffe, E.S.: CD5 expression in B-cell small lymphocytic malignancies: correlations with clinical presentation and sites of disease. Am. J. Surg. Pathol. 16: 130-137, 1992. PMID: 1370753

349. Longo, D.L. and DeVita, V.T., Jr.: The use of combination chemotherapy in the treatment of early stage Hodgkin’s disease. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Important Advances in Oncology 1992. Philadelphia, J.B. Lippincott, 1992, pp. 155-165. PMID: 1582671

350. Urba, W.J. and Longo, D.L.: Hodgkin’s disease. N. Engl. J. Med. 326: 678-687, 1992. PMID: 1736106

351. Yano, T., Van Krieken, J.H.J.M., Magrath, I.T., Longo, D.L., Jaffe, E.S., Raffeld, M.: Histogenetic correlation between subcategories of small noncleaved cell lymphomas. Blood 79: 1282-1290, 1992. PMID: 1311213

352. Longo, D.L. and DeVita, Jr., V.T.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 13. Amsterdam, Elsevier Science Publishers B.V., 1992, pp. 349-403. PMID: 1389915

353. Murphy, W.J., Bennett, M., Kumar, V., and Longo, D.L.: Donor-type activated natural killer cells promote marrow engraftment and B cell development during allogeneic bone marrow transplantation. J. Immunol. 148: 2953-2960, 1992. PMID: 1573278

354. Wiltrout, R.H., Damia, G., MacPhee, M., Futami, H., Faltynek, C.R., Longo, D.L., Ruscetti, F.W., and Komschlies, K.L.: Cytokine-based combined modality approaches to the treatment of murine renal cancer. In Goldstein, A.L. and Garaci, E. (Eds.): Biological Response Modifiers in the Treatment of Cancer and Infectious Diseases. New York, Plenum Publishing Corporation, 1992, pp. 269-274.

355. Fenton, R.G., Kung, H-F., Longo, D.L., and Smith, M.R.: Regulation of intracellular actin polymerization by prenylated cellular proteins. J. Cell Biol. 117: 347-356, 1992. PMID: 1560030

356. Urba, W.J., Ewel, C., Kopp, W., Smith, J.W., II, Steis, R.G., Ashwell, J.D., Creekmore, S.P., Rossio, J., Sznol, M., Sharfman, W., Fenton, R., Janik, J., Conlon, K., Watson, T., Beveridge, J., and Longo, D.L.: Anti-CD3 monoclonal antibody treatment of patients with CD3-negative tumors: a phase Ia/b study. Cancer Res. 52: 2394-2401, 1992. PMID: 1533172

357. Longo, D.L.: Introduction: section on monitoring immunological therapies. In Rose, N.R., de Macario, E.C., Fahey, J.L., Friedman, H., and Penn, G.M. (Eds.): Manual of Clinical Laboratory Immunology, Fourth Edition. Washington, American Society for Microbiology, 1992, pp. 913-914.

358. Creekmore, S.P., Urba, W.J., and Longo, D.L.: Strategies for clinical monitoring of therapeutic trials. In Rose, N.R., de Macario, E.C., Fahey, J.L., Friedman, H., and Penn, G.M. (Eds.): Manual of Clinical Laboratory Immunology, Fourth Edition. Washington, American Society for Microbiology, 1992, pp. 915-922.

359. Murphy, W.J., Durum, S.K., and Longo, D.L.: Human growth hormone promotes engraftment of murine or human T cells in severe combined immunodeficient mice. Proc. Natl. Acad. Sci. USA 89: 4481-4485, 1992. PMID: 1584780

360. Ochoa, J.B., Curti, B., Peitzman, A.B., Simmons, R.L., Billiar, T.R., Hoffman, R., Rault, R., Longo, D.L., Urba, W.J., and Ochoa, A.C.: Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. J. Natl. Cancer Inst. 84: 864-867, 1992. PMID: 1375656

361. Ewel, C.H., Urba, W.J., Kopp, W.C., Smith, J.W., II, Steis, R.G., Rossio, J.L., Longo, D.L., Jones, M.J., Alvord, W.G., Pinsky, C.M., Beveridge, J.M., McNitt, K.L., and Creekmore, S.P.: Polyinosinic-polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose in combination with interleukin 2 in patients with cancer: clinical and immunological effects. Cancer Res. 52: 3005-3010, 1992. PMID: 1591717

362. Sznol, M., Clark, J.W., Smith, J.W., II, Steis, R.G., Urba, W.J., Rubinstein, L.V., VanderMolen, L.A., Janik, J., Sharfman, W.H., Fenton, R.G., Creekmore, S.P., Kremers, P., Conlon, K., Hursey, J., Beveridge, J., and Longo, D.L.: A pilot study of interleukin-2 and lymphokine- activated killer cells combined with immunomodulatory doses of chemotherapy and sequenced with interferon alfa2a in patients with metastatic melanoma and renal cell carcinoma. J. Natl. Cancer Inst. 84: 929-937, 1992. PMID: 1629914

363. Murphy, W.J., Durum, S.K., Anver, M.R., and Longo, D.L.: Immunologic and hematologic effects of neuroendocrine hormones: studies on DW/J dwarf mice. J. Immunol. 148: 3799-3805, 1992. PMID: 1602129

364. Murphy, W.J., Bennett, M., Anver, M.R., Baseler, M., and Longo, D.L.: Human-mouse lymphoid chimeras: host-vs.-graft and graft-vs.-host reactions. Eur. J. Immunol. 22: 1421-1427, 1992. PMID: 1534757

365. Sznol, M., Steis, R.G., Smith, J.W., II, Janik, J.E., Sharfman, W.H., Urba, W.J., Fenton, R.G., Creekmore, S.P., Beveridge, J., and Longo, D.L.: Intensive therapy with cisplatin, interleukin-2 and interferon-alpha2a in patients with metastatic melanoma: a phase II study. Online J. Curr. Clin. Trials July 1 (Doc No. 9): 3841 words;32 paragraphs, 1992. PMID: 1343617

366. Hornung, R.L. and Longo, D.L.: Hematopoietic stem cell depletion by restorative growth factor regimens during repeated high-dose cyclophosphamide therapy. Blood 80: 77-83, 1992. PMID: 1377055

367. Smith, J.W., II, Urba, W.J., Curti, B.D., Elwood, L.J., Steis, R.G., Janik, J.E., Sharfman, W.H., Miller, L.L., Fenton, R.G., Conlon, K.C., Sznol, M., Creekmore, S.P., Wells, N.F., Ruscetti, F.W., Keller, J.R., Hestdal, K., Shimizu, M., Rossio, J., Alvord, W.G., Oppenheim, J.J., and Longo, D.L.: The toxic and hematologic effects of interleukin-1 alpha administered in a phase I trial to patients with advanced malignancies. J. Clin. Oncol. 10: 1141-1152, 1992. PMID: 1607919

368. Loeffler, C.M., Smyth, M.J., Longo, D.L., Kopp, W.C., Harvey, L.K., Tribble, H.R., Tase, J.E., Urba, W.J., Leonard, A.S., Young, H.A., and Ochoa, A.C.: Immunoregulation in cancer-bearing hosts: down-regulation of gene expression and cytotoxic function in CD8+ T cells. J. Immunol. 149: 949-956, 1992. PMID: 1353099

369. Damia, G., Komschlies, K.L., Futami, H., Back, T., Gruys, M.E., Longo, D.L., Keller, J.R., Ruscetti, F.W., and Wiltrout, R.H.: Prevention of acute chemotherapy-induced death in mice by recombinant human interleukin 1: protection from hematological and nonhematological toxicities. Cancer Res. 52: 4082-4089, 1992. PMID: 1638519

370. Murphy, W.J. and Longo, D.L.: Hematopoietic growth-promoting effects of natural killer cells in mice in response to in vivo administration of human interleukin-2. J. Natl. Cancer Inst. 84: 1195-1200, 1992. PMID: 1635088

371. Longo, D.L., Duffey, P.L., Hubbard, S.M., Young, R.C., and DeVita, V.T., Jr.: Radiation therapy is better than chemotherapy in early-stage Hodgkin’s disease? Not so fast. J. Clin. Oncol. 10: 1367-1369, 1992. PMID: 1634930

372. Murphy, W.J., Keller, J.R., Harrison, C.L., Young, H.A., and Longo, D.L.: Interleukin-2-activated natural killer cells can support hematopoiesis in vitro and promote marrow engraftment in vivo. Blood 80: 670-677, 1992. PMID: 1379086

373. Yano, T., Jaffe, E.S., Longo, D.L., and Raffeld, M.: MYC rearrangements in histologically progressed follicular lymphomas. Blood 80: 758-767, 1992. PMID: 1638027

374. Tan, T-H., Huang, G.P., Sica, A., Ghosh, P., Young, H.A., Longo, D.L., and Rice, N.A.: B site-dependent activation of the interleukin-2 receptor -chain gene promoter by human c-Rel. Mol. Cell. Biol. 12: 4067-4075, 1992. PMID: 1508203

375. Zarate-Osorno, A., Medeiros, L.J., Longo, D.L., and Jaffe, E.S.: Non-Hodgkin’s lymphomas arising in patients successfully treated for Hodgkin’s disease. A clinical, histologic, and immunophenotypic study of 14 cases. Am. J. Surg. Pathol. 16: 885-895, 1992. PMID: 1415907

376. Murphy, W.J., Tsarfaty, G., and Longo, D.L.: Growth hormone exerts hematopoietic growth-promoting effects in vivo and partially counteracts the myelosuppressive effects of azidothymidine. Blood 80: 1443-1447, 1992. PMID: 1520871

377. Kaufman, D. and Longo, D.L.: Hodgkin’s disease. Crit. Rev. Oncol. Hematol. 13: 135-187, 1992. PMID: 1418644

378. Kennedy, I.C.S. and Longo, D.L.: Salvage therapy for Hodgkin’s disease. Contemp. Oncol. 2(8): 16-25, 1992.

379. Espinoza-Delgado, I., Longo, D.L., Gusella, G.L., and Varesio, L.: Regulation of IL-2 receptor subunit genes in human monocytes. Differential effects of IL-2 and IFN-. J. Immunol. 149: 2961-2968, 1992. PMID: 1383334

380. Wilson, W.H., Jain, V., Bryant, G., Cowan, K.H., Carter, C., Cottler-Fox, M., Goldspiel, B., Steinberg, S.M., Longo, D.L., and Wittes, R.E.: A phase I and II study of high-dose ifosfamide, carboplatin, and etoposide with autologous bone marrow rescue in lymphomas and solid tumors. J. Clin. Oncol. 10: 1712-1722, 1992. PMID: 1403054

381. Urba, W.J., Wilson, W.H., Duffey, P.L., Wittes, R., Chabner, B.A., and Longo, D.L.: Recent National Cancer Institute lymphoma trials of etoposide-containing combination chemotherapy. Semin. Oncol. 19 (suppl 13): 26-32, 1992. PMID: 1283467

382. Hestdal, K., Jacobsen, S.E.W., Ruscetti, F.W., Dubois, C.M., Longo, D.L., Chizzonite, R., Oppenheim, J.J., and Keller, J.R.: In vivo effect of interleukin-1 on hematopoiesis: role of colony-stimulating factor receptor modulation. Blood 80: 2486-2494, 1992. PMID: 1384785

383. Conlon, K.C., Ochoa, A.C., Kopp, W.C., Ortaldo, J.R., Longo, D.L., and Young, H.A.: Enhanced lymphokine production and lymphokine receptor expression in multiple antibody-stimulated human CD4+ peripheral blood lymphocytes. J. Immunol. 149: 3278-3289, 1992. PMID: 1358968

384. Murphy, W.J., Durum, S.K., and Longo, D.L.: Role of neuroendocrine hormones in murine T cell development: growth hormone exerts thymopoietic effects in vivo. J. Immunol. 149: 3851-3857, 1992. PMID: 1460277

385. Sotos, G.A., Liebmann, J.E., Kohler, D.R., and Longo, D.L.: Reactivation of thermal burn by methotrexate. J. Natl. Cancer Inst. 84: 1936-1938, 1992. PMID: 1460675

386. Mizoguchi, H., O’Shea, J.J., Longo, D.L., Loeffler, C.M., McVicar, D.W., and Ochoa, A.C.: Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258: 1795-1798, 1992. PMID: 1465616

387. Kenny, J.J., Moratz, C.M., Guelde, G., O’Connell, C.D., George, J., Dell, C., Penner, S.J., Weber, J.S., Berry, J., Claflin, J.L., and Longo, D.L.: Antigen binding and idiotype analysis of antibodies obtained following electroporation of heavy and light chain genes encoding phosphocholine-specific antibodies: a model for T15-idiotype dominance. J. Exp. Med. 176: 1637-1643, 1992. PMID: 1460422

388. Mueller, B.U., Skelton, J., Callender, D.P.E., Marshall, D., Gress, J., Longo, D., Norton, J., Rubin, M., Venzon, D., and Pizzo, P.A.: A prospective randomized trial comparing the infectious and noninfectious complications of an externalized catheter versus a subcutaneously implanted device in cancer patients. J. Clin. Oncol. 10: 1943-1948, 1992. PMID: 1453208

389. Kenny, J.J., Sieckmann, D.G., Freter, C., Hodes, R., Hathcock, K., and Longo, D.L.: Modulation of signal transduction in phosphocholine-specific B cells from  transgenic mice. Curr. Top. Microbiol. Immunol. 182: 95-103, 1992. PMID: 1490394

390. Murphy, W.J., Durum, S.K., Anver, M., Frazier, M., and Longo, D.L.: Recombinant human growth hormone promotes human lymphocyte engraftment in immunodeficient mice and results in an increased incidence of human Epstein Barr Virus-induced B-cell lymphoma. Brain Behav. Immun. 6: 355-364, 1992. PMID: 1336993

391. Oppenheim, J.J., Neta, R., Smith, J.W., II, and Longo, D.L.: Neuroendocrine and other in vivo effects of interleukin-1 in mouse and man. In Bartfai, T. and Ottoson, D. (Eds.): Neuroimmunology of Fever. Oxford, Pergamon Press, 1992, pp. 79-86.

392. Longo, D.L.: Oncology. In Joyce, M. (Ed.): Encyclopedia of Science & Technology, 7th edition, vol. 12. New York, McGraw-Hill Publishing Company, pp. 359-365, 1992.

393. Creekmore, S.P. and Longo, D.L.: Cytokines in oncology. In Niederhuber, J.E. (Ed.): Current Therapy in Oncology. St. Louis, Mosby-Year Book, Inc., pp. 36-41, 1993.

394. Janik, J., Kopp, W.C., Smith, J.W., II, Longo, D.L., Alvord, W.G., Sharfman, W.H., Fenton, R.G., Sznol, M., Steis, R.G., Creekmore, S.P., Ewel, C.H., Hursey, J., and Urba, W.J.: Dose-related immunologic effects of levamisole in patients with cancer. J. Clin. Oncol. 11: 125-135, 1993. PMID: 8418223

395. Longo, D.L.: Editorial: What’s the deal with follicular lymphomas? J. Clin. Oncol. 11: 202-208, 1993. PMID: 8426195

396. Longo, D.L., DeVita, V.T., Jr., Jaffe, E.S., Mauch, P., and Urba, W.J.: Lymphocytic lymphoma. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Cancer: Principles and Practice of Oncology, Fourth Edition. Philadelphia, J.B. Lippincott Company, 1993, pp. 1859-1921.

397. Zarate-Osorno, A., Medeiros, L.J., Kingma, D.W., Longo, D.L., and Jaffe, E.S.: Hodgkin’s disease following non-Hodgkin’s lymphoma: a clinicopathologic and immunophenotypic study of nine cases. Am. J. Surg. Pathol. 17: 123-132, 1993. PMID: 8422110

398. Sznol, M. and Longo, D.L.: Chemotherapy drug interactions with biological agents. Semin. Oncol. 20: 80-93, 1993. PMID: 8475413

399. Hirose, K., Longo, D.L., Oppenheim, J.J., and Matsushima, K.: Overexpression of mitochondrial manganese superoxide dismutase promotes the survival of tumor cells exposed to interleukin-1, tumor necrosis factor, selected anticancer drugs, and ionizing radiation. FASEB J. 7: 361-368, 1993. PMID: 8440412

400. Smith, J.W., II, Longo, D.L., Alvord, W.G., Janik, J.E., Sharfman, W.H., Gause, B.L., Curti, B.D., Creekmore, S.P., Holmlund, J.T., Fenton, R.G., Sznol, M., Miller, L.L., Shimizu, M., Oppenheim, J.J., Fiem, S.J., Hursey, J.C., Powers, G.C., and Urba, W.J.: The effects of treatment with interleukin-1 on platelet recovery after high-dose carboplatin. N. Engl. J. Med. 328: 756-761, 1993. PMID: 8437596

401. Beckwith, M., Urba, W.J., and Longo, D.L.: Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15. J. Natl. Cancer Inst. 85: 483-488, 1993. PMID: 8445676

402. Kopp, W.C., Smith, J.W., II, Ewel, C.H., Alvord, W.G., Main, C., Guyre, P.M., Steis, R.G., Longo, D.L., and Urba, W.J.: Immunomodulatory effects of interferon- in patients with metastatic malignant melanoma. J. Immunother. 13: 181-190, 1993. PMID: 8471592

403. Curti, B.D., Longo, D.L., Ochoa, A.C., Conlon, K.C., Smith, J.W., II, Alvord, W.G., Creekmore, S.P., Fenton, R.G., Gause, B.L., Holmlund, J., Janik, J.E., Ochoa, J., Rice, P.A., Sharfman, W.H., Sznol, M., and Urba, W.J.: Treatment of cancer patients with ex vivo anti-CD3-activated killer cells and interleukin-2. J. Clin. Oncol. 11: 652-660, 1993. PMID: 8257476

404. Murphy, W.J., Conlon, K.C., Sayers, T.J., Wiltrout, R.H., Back, T.C., Ortaldo, J.R., and Longo, D.L.: Engraftment and activity of anti-CD3-activated human peripheral blood lymphocytes transferred into mice with severe combined immune deficiency. J. Immunol. 150: 3634-3642, 1993. PMID: 8468492

405. Longo, D.L. and Duffey, P.L.: Management of aggressive histology lymphoma: an approach based on data from the National Cancer Institute. Hem/Onc. Annals 1: 19-28, 1993.

406. Curti, B.D., Urba, W.J., Alvord, W.G., Janik, J.E., Smith, J.W., II, Madara, K., and Longo, D.L.: Interstitial pressure of subcutaneous nodules in melanoma and lymphoma patients: changes during treatment. Cancer Res. 53: 2204-2207, 1993. PMID: 8485703

407. O’Connor, P.M., Ferris, D.K., Pagano, M., Draetta, G., Pines, J., Hunter, T., Longo, D.L., and Kohn, K.W.: G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J. Biol. Chem. 268: 8298-8308, 1993. PMID: 8463339

408. Pearson, J.W., Fogler, W.E., Volker, K., Riggs, C.W., Gruys, E., Groves, E.S., Wiltrout, R.H., and Longo, D.L.: Restoration of interferon potentiation of a recombinant ricin A chain immunotoxin following cytoreduction of xenografts of advanced ovarian tumors. J. Natl. Cancer Inst. 85: 907-912, 1993. PMID: 8492319

409. Li, C-C.H., Chen, E., O’Connell, C.D., and Longo, D.L.: Detection of c-mos proto-oncogene expression in human cells. Oncogene 8: 1685-1691, 1993. PMID: 8502488

410. Li, C-C.H., Ruscetti, F.W., Rice, N.R., Chen, E., Yang, N-S., Mikovits, J., and Longo, D.L.: Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein. J. Virol. 67: 4205-4213, 1993.

411. Hestdal, K., Jacobsen, S.E.W., Ruscetti, F.W., Longo, D.L., Boone, T.C., and Keller, J.R.: Increased granulopoiesis after sequential administration of transforming growth factor-1 and granulocyte-macrophage colony-stimulating factor. Exp. Hematol. 21: 799-805, 1993. PMID: 8500577

412. Hollingsworth, H.C., Longo, D.L., and Jaffe, E.S.: Small noncleaved cell lymphoma associated with florid epithelioid granulomatous response: a clinicopathologic study of seven patients. Am. J. Surg. Pathol. 17: 51-59, 1993. PMID: 8447509

413. Murphy, W.J., Durum, S.K., and Longo, D.L.: Differential effects of growth hormone and prolactin on murine T cell development and function. J. Exp. Med. 178: 231-236, 1993. PMID: 8315380

414. Fenton, R.G., Taub, D.D., Kwak, L.W., Smith, M.R., and Longo, D.L.: Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogenes. J. Natl. Cancer Inst. 85: 1294-1302, 1993. PMID: 8340941

415. Janik, J., Kopp, W.C., Smith, J.W., II, Longo, D.L., Alvord, W.G., and Urba, W.J.: Levamisole-induced neopterin synthesis. Ann. NY Acad. Sci. 685: 252-258, 1993. PMID: 8363229

416. Murphy, W.J., Reynolds, C.W., Tiberghien, P., and Longo, D.L.: Natural killer cells and bone marrow transplantation. J. Natl. Cancer Inst. 85: 1475-1482, 1993. PMID: 8360930

417. Phillips, G.L. and Longo, D.L.: Indications for high-dose therapy with hematopoietic support in patients with Hodgkin’s disease. Leukemia 7: 1087-1090, 1993. PMID: 8321031

418. Yano, T., Sander, C.A., Andrade, R.E., Gauwerky, C.E., Croce, C.M., Longo, D.L., Jaffe, E.S., and Raffeld, M.: Molecular analysis of the BCL-3 locus at chromosome 17q22 in B-cell neoplasms. Blood 82: 1813-1819, 1993. PMID: 8400234

419. Longo, D.L., DeVita, V.T., Jr., and Young, R.C.: Letter to the Editor: CHOP versus intensive regimens in non-Hodgkin’s lymphoma. N. Engl. J. Med. 329: 580-581, 1993. PMID: 7687747

420. Horowitz, M.E., Kinsella, T.J., Wexler, L.H., Belasco, J., Triche, T., Tsokos, M., Steinberg, S.M., McClure, L., Longo, D.L., Steis, R.G., Glatstein, E., Pizzo, P.A., and Miser, J.S.: Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing’s sarcoma and rhabdomyosarcoma. J. Clin. Oncol. 11: 1911-1918, 1993. PMID: 8410118

421. Sander, C.A., Yano, T., Clark, H.M., Harris, C., Longo, D.L., Jaffe, E.S., and Raffeld, M.: p53 mutation is associated with progression in follicular lymphomas. Blood 82: 1994-2004, 1993. PMID: 8400252

422. Urba, W.J. and Longo, D.L.: Hodgkin’s disease in adults. Part I. Invest. Radiol. 28: 737-752, 1993. PMID: 8376007

423. Urba, W.J. and Longo, D.L.: Hodgkin’s disease in adults. Part II. Invest. Radiol. 28: 848-859, 1993. PMID: 8225893

424. Longo, D.L.: Editorial: Is anything better than MOPP? Hematologic. Oncol. 11: 65-71, 1993. PMID: 8406376

425. Murphy, W.J., Back, T.C., Conlon, K.C., Komschlies, K.L., Ortaldo, J.R., Sayers, T.J., Wiltrout, R.H., and Longo, D.L.: Antitumor effects of interleukin-7 and adoptive immunotherapy on human colon carcinoma xenografts. J. Clin. Invest. 92: 1918-1924, 1993. PMID: 8408644

426. Siefer, A.K., Longo, D.L., Harrison, C.L., Reynolds, C.W., and Murphy, W.J.: Activated natural killer cells and interleukin-2 promote granulocytic and megakaryocytic reconstitution after syngeneic bone marrow transplantation in mice. Blood 82: 2577-2584, 1993. PMID: 8400305

427. Creekmore, S.P., Reynolds, C.W., Hecht, T.T., Urba, W.J., and Longo, D.L.: Interleukin-2 therapy for human cancer. In Oppenheim, J.J., Rossio, J.L., and Gearing, A.J.H. (Eds.): Clinical Applications of Cytokines: Role in Pathogenesis, Diagnosis and Therapy. Oxford, Oxford University Press, 1993, pp. 147-154.

428. Longo, D.L.: Treatment of aggressive lymphomas: recent progress and future prospects. In Kimura, K., Yamada, K., Carter, S.K., and Longo, D.L. (Eds.): Cancer Chemotherapy: Challenges for the Future, Vol. 8. Tokyo, Excerpta Medica, Ltd., 1993, pp. 3-14.

429. Kwak, L.W., DeVita, Jr., V.T., and Longo, D.L.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 14. Amsterdam, Elsevier Science Publishers B.V., 1993, pp. 383-426. PMID: 8312110

430. Wang, J., Raffeld, M., Medeiros, L.J., Longo, D.L., Jaffe, E.S., Duffey, P., and Stetler-Stevenson, M.: Follicular center cell lymphoma with the t(14;18) translocation in which the rearranged BCL-2 gene is silent. Leukemia 7: 1834-1839, 1993. PMID: 7694006

431. Janik, J.E., Sznol, M., Urba, W.J., Figlin, R., Bukowski, R.M., Fyfe, G., Pierce, W.C., Belldegrun, A., Sharfman, W.H., Smith, J.W., II, and Longo, D.L.: Erythropoietin production: a potential marker for interleukin-2/interferon-responsive tumors. Cancer 72: 2656-2659, 1993. PMID: 8402486

432. Williams, M.E., Lister, T.A., and Longo, D.L.: Hodgkin’s disease and non-Hodgkin’s lymphoma. ASH Educational Booklet 49-61, 1993.

433. Finke, J.H., Zea, A.H., Stanley, J., Longo, D.L., Mizoguchi, H., Tubbs, R.R., Wiltrout, R.H., O’Shea, J.J., Kudoh, S., Klein, E., Bukowski, R.M., and Ochoa, A.C.: Loss of T-cell receptor  chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res. 53: 5613-5616, 1993. PMID: 8242613

434. Aiello, F.B., Gusella, L., Longo, D.L., Birchenall-Roberts, M., Takacs, L., Takei, F., Ruscetti, F., Musiani, P., and Durum, S.K.: Inducible accessory function of a macrophage cell line. Immunopharmacol. Immunotoxicol. 15: 327-353, 1993. PMID: 7901265

435. Longo, D.L., Banks, P.M., and Hoppe, R.T.: Hodgkin’s disease. La Rev. De Invest. Clin. 45 (suppl): 73-83, 1993. PMID: 7886314

436. Bosco, M.C., Gusella, G.L., Espinoza-Delgado, I., Longo, D.L., and Varesio, L.: Interferon- upregulates interleukin-8 gene expression in human monocytic cells by a posttranscriptional mechanism. Blood 83: 537-542, 1994. PMID: 8286750

437. Hamanaka, R., Maloid, S., Smith, M.R., O’Connell, C.D., Longo, D.L., and Ferris, D.K.: Cloning and characterization of human and murine homologues of the Drosophila polo serine-threonine kinase. Cell Growth Differ. 5: 249-257, 1994. PMID: 8018557

438. Musso, T., Gusella, G.L., Brooks, A., Longo, D.L., and Varesio, L.: Interleukin-4 inhibits indoleamine 2,3-dioxygenase expression in human monocytes. Blood 83: 1408-1411, 1994. PMID: 8118042

439. Longo, D.L.: Follicular lymphoma. In Foley, J.F., Vose, J.M., and Armitage, J.O. (Eds.): Current Therapy in Oncology. Philadelphia, W.B. Saunders, 1994, pp. 255-261.

440. Longo, D.L.: Plasma cell disorders. In Isselbacher, K.J., Braunwald, E., Wilson, J.D., Martin, J.B., Fauci, A.S., and Kasper, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 13th Edition. New York, McGraw-Hill Book Company, 1994, pp. 1618-1625.

441. Norihisa, Y., McVicar, D.W., Ghosh, P., Houghton, A.N., Longo, D.L., Creekmore, S.P., Blake, T., Ortaldo, J.R., and Young, H.A.: Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3). J. Immunol. 152: 485-495, 1994. PMID: 8283032

442. Kenny, J.J., Guelde, G., Fischer, R.T., and Longo, D.L.: Induction of phosphocholine-specific antibodies in X-linked immune deficient mice: in vivo protection against a Streptococcus pneumoniae challenge. Int. Immunol. 6: 561-568, 1994. PMID: 8018596

443. Sarkar, F.H., Smith, M.R., Hoover, T., Princler, G., Crissman, J.D., Visscher, D.W., Longo, D.L., Kung, H-F., and Raziuddin: c-erbB-2 promoter-specific DNA-binding protein isolated from human breast cancer tissues displays mitogenic activity. J. Biol. Chem. 269: 12285-12289, 1994. PMID: 7909319

444. Sieckmann, D.G., Holmes, K., Hornbeck, P., Martin, E., Guelde, G., Bondada, S., Longo, D.L., and Kenny, J.J.: B cells from M167  transgenic mice fail to proliferate after stimulation with soluble anti-Ig antibodies. A model for antigen-induced B cell anergy. J. Immunol. 152: 4873-4883, 1994. PMID: 8176209

445. Janik, J.E. and Longo, D.L.: Laboratory characterization of malignancies of the immune system. Immunol. Allergy Clin. North Am. 14: 301-322, 1994.

446. Funakoshi, S., Longo, D.L., Beckwith, M., Conley, D.K., Tsarfaty, G., Tsarfaty, I., Armitage, R.J., Fanslow, W.C., Spriggs, M.K., and Murphy, W.J.: Inhibition of human B-cell lymphoma growth by CD40 stimulation. Blood 83: 2787-2794, 1994. PMID: 7514045

447. Bosco, M.C., Espinoza-Delgado, I., Schwabe, M., Gusella, G.L., Longo, D.L., Sugamura, K., and Varesio, L.: Regulation by interleukin-2 (IL-2) and interferon  of IL-2 receptor  chain gene expression in human monocytes. Blood 83: 2995-3002, 1994. PMID: 8180396

448. Espinoza-Delgado, I., Bosco, M.C., Musso, T., Mood, K., Ruscetti, F.W., Longo, D.L., and Varesio, L.: Inhibitory cytokine circuits involving transforming growth factor-, interferon-, and interleukin-2 in human monocyte activation. Blood 83: 3332-3338, 1994. PMID: 8193369

449. Bosco, M.C., Espinoza-Delgado, I., Schwabe, M., Russell, S.M., Leonard, W.J., Longo, D.L., and Varesio, L.: The  subunit of the interleukin-2 receptor is expressed in human monocytes and modulated by interleukin-2, interferon , and transforming growth factor 1. Blood 83: 3462-3467, 1994. PMID: 8204874

450. Ghosh, P., Sica, A., Young, H.A., Ye, J., Franco, J.L., Wiltrout, R.H., Longo, D.L., Rice, N.R., and Komschlies, K.L.: Alterations in NF-B/Rel family proteins in splenic T-cells from tumor-bearing mice and reversal following therapy. Cancer Res. 54: 2969-2972, 1994. PMID: 8187083

451. Linnekin, D., Howard, O.M.Z., Park, L., Farrar, W., Ferris, D., and Longo, D.L.: Hck expression correlates with granulocyte-macrophage colony-stimulating factor-induced proliferation in HL-60 cells. Blood 84: 94-103, 1994. PMID: 8018933

452. Hestdal, K., Ruscetti, F.W., Chizzonite, R., Ortiz, M., Gooya, J.M., Longo, D.L., and Keller, J.R.: Interleukin-1 (IL-1) directly and indirectly promotes hematopoietic cell growth through type I IL-1 receptor. Blood 84: 125-132, 1994. PMID: 8018912

453. Musso, T., Bosco, M.C., Longo, D.L., Espinoza-Delgado, I., Sica, A., Cox, G.W., Gusella, G.L., Forni, G., and Varesio, L.: LPS-inducible nuclear factor in human monocytes that binds the negative regulatory element of the HIV LTR. J. Leukoc. Biol. 56: 21-26, 1994. PMID: 8027666

454. Longo, D.L.: Non-Hodgkin’s lymphoma. Curr. Opin. Hematol. 1: 295-302, 1994. PMID: 9371296

455. Taub, D.D., Tsarfaty, G., Lloyd, A.R., Durum, S.K., Longo, D.L., and Murphy, W.J.: Growth hormone promotes human T cell adhesion and migration to both human and murine matrix proteins in vitro and directly promotes xenogeneic engraftment. J. Clin. Invest. 94: 293-300, 1994. PMID: 7518833

456. Murphy, W.J., Durum, S.K., Anver, M.R., Ferris, D.K., McVicar, D.W., O’Shea, J.J., Ruscetti, S.K., Smith, M.R., Young, H.A., and Longo, D.L.: Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID). J. Immunol. 153: 1004-1014, 1994. PMID: 7913108

457. Tiberghien, P., Reynolds, C.W., Keller, J., Spence, S., Deschaseaux, M., Certoux, J-M., Contassot, E., Murphy, W.J., Lyons, R., Chiang, Y., Herve, P., Longo, D.L., and Ruscetti, F.W.: Ganciclovir treatment of herpes simplex thymidine kinase-transduced primary T-lymphocytes: an approach for specific in vivo donor T-cell depletion after bone marrow transplantation? Blood 84: 1333-1341, 1994.

458. Longo, D.L.: Prefatory chapter: Cytokines, genes, and cancer therapy. In Forni, G., Foa, R., Santoni, A., and Frati, L. (Eds.): Cytokine-Induced Tumor Immunogenicity. From Exogenous Molecules to Gene Therapy. London, Academic Press, 1994, pp. xxi-xxv.

459. Longo, D.L.: New clinical prospects. In Forni, G., Foa, R., Santoni, A., and Frati, L. (Eds.): Cytokine-Induced Tumor Immunogenicity. From Exogenous Molecules to Gene Therapy. London, Academic Press, 1994, pp. 469-480.

460. Longo, D.L.: Commentary: The Palackdharry article reviewed. Oncology 8: 73-77, 1994.

461. Murphy, W.J., Taub, D.D., Anver, M., Conlon, K., Oppenheim, J.J., Kelvin, D.J., and Longo, D.L.: Human RANTES induces the migration of human T lymphocytes into the peripheral tissues of mice with severe combined immune deficiency. Eur. J. Immunol. 24: 1823-1827, 1994. PMID: 7519996

462. Grzegorzewski, K., Ruscetti, F.W., Usui, N., Damia, G., Longo, D.L., Carlino, J.A., Keller, J.R., and Wiltrout, R.H.: Recombinant transforming growth factor 1 and 2 protect mice from acutely lethal doses of 5-fluorouracil and doxorubicin. J. Exp. Med. 180: 1047-1057, 1994. PMID: 8064224

463. Kwak, L.W. and Longo, D.L.: Lymphoproliferative disorders. In Frank, M.M., Austen, K.F., Claman, H.N., and Unanue, E.R. (Eds.): Samter’s Immunologic Diseases, Fifth Edition. Boston, Little, Brown and Company, 1994, pp. 551-597.

464. Johnston, J.A., Ferris, D.K., Wang, J.M., Longo, D.L., Oppenheim, J.J., and Kelvin, D.J.: Staurosporine restores signaling and inhibits interleukin-8-induced chemotactic desensitization. Eur. J. Immunol. 24: 2556-2562, 1994. PMID: 7925583

465. Li, C-C.H., Korner, M., Ferris, D.K., Chen, E., Dai, R.M., and Longo, D.L.:
NF-B/Rel family members are physically associated phosphoproteins. Biochem. J. 303: 499-506, 1994. PMID: 7980409

466. Whang-Peng, J., Knutsen, T., Jaffe, E., Raffeld, M., Zhao, W.P., Duffey, P., and Longo, D.L.: Cytogenetic study of two cases with lymphoma of mucosa-associated lymphoid tissue. Cancer Genet. Cytogenet. 77: 74-80, 1994. PMID: 7923088

467. Tsarfaty, G., Longo, D.L., and Murphy, W.J.: Human insulin-like growth factor I exerts hematopoietic growth-promoting effects after in vivo administration. Exp. Hematol. 22: 1273-1277, 1994. PMID: 7957713

468. Longo, D.L., Duffey, P.L., Jaffe, E.S., Raffeld, M., Hubbard, S.M., Fisher, R.I., Wittes, R.E., DeVita, Jr., V.T., and Young, R.C.: Diffuse small noncleaved-cell, non-Burkitt’s lymphoma in adults: a high-grade lymphoma responsive to ProMACE-based combination chemotherapy. J. Clin. Oncol. 12: 2153-2159, 1994. PMID: 7523607

469. Kim, W.K., Tang, Y., Kenny, J.J., Longo, D.L., and Morse III, H.C.: In murine AIDS, B cells are early targets of defective virus and are required for efficient infection and expression of defective virus in T cells and macrophages. J. Virol. 68: 6767-6769, 1994. PMID: 8084011

470. Li, C-C.H., Dai, R-M., Chen, E., and Longo, D.L.: Phosphorylation of NF-B1-p50 is involved in NF-B activation and stable DNA binding. J. Biol. Chem. 269: 30089-30092, 1994. PMID: 7982908

471. Kwak, L.W., DeVita, V.T., Jr., and Longo, D.L.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 15. Amsterdam, Elsevier Science Publishers B.V., 1994, pp. 413-470. PMID: 7779591

472. Steis, R.G. and Longo, D.L.: Clinical relevance of recombinant interferon-2a antibodies in patients with hairy cell leukemia. J. Interferon Res. 14: 207-209, 1994. PMID: 7822877

473. Ochoa, A.C., Curti, B.D., Zea, A.H., Anderson, P.M., Saxton, M., Strobl, S.S., Kopp, W.C., Urba, W.J., and Longo, D.L.: Anti-CD3-stimulated T cells and IL2 liposomes in adoptive immunotherapy: advantages and limitations. In Chang, A.E., and Shu, S. (Eds.): Immunotherapy of Cancer with Sensitized T Lymphocytes. Austin, R.G. Landes, Co., 1994, pp. 69-78.

474. Curti, B.D. and Longo, D.L.: Specific oncologic issues in the critically ill. In Parrillo, J.E., and Bone, R.C. (Eds.): Critical Care Medicine: Principles of Diagnosis and Management. St. Louis, Mosby-Year Book, Inc., 1995, pp. 1345-1362.

475. Whang-Peng, J., Knutsen, T., Jaffe, E.S., Steinberg, S.M., Raffeld, M., Zhao, W.P., Duffey, P., Condron, K., Yano, T., and Longo, D.L.: Sequential analysis of 43 patients with non-Hodgkin’s lymphoma: clinical correlations with cytogenetic, histologic, immunophenotyping and molecular studies. Blood 85: 203-216, 1995. PMID: 7803794

476. Fogler, W.E., Pearson, J.W., Volker, K., Ariyoshi, K., Watabe, H., Riggs, C.W., Wiltrout, R.H., and Longo, D.L.: Enhancement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody. J. Natl. Cancer Inst. 87: 94-104, 1995. PMID: 7707396

477. Sela, S., Husain, S.R., Pearson, J.W., Longo, D.L., and Rahman, A.: Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil. J. Natl. Cancer Inst. 87: 123-128, 1995. PMID: 7707383

478. Holmlund, J.T., Kopp, W.C., Wiltrout, R.H., Longo, D.L., Urba, W.J., Janik, J.E., Sznol, M., Conlon, K.C., Fenton, R.G., Hornung, R., Madara, K., Shields, M.A., Smith II, J.W., Sharfman, W., Steis, R.G., Ewel, C., Malspeis, L., and Creekmore, S.P.: A phase I clinical trial of flavone-8-acetic acid in combination with interleukin-2. J. Natl. Cancer Inst. 87: 134-136, 1995. PMID: 7707385

479. Espinoza-Delgado, I., Bosco, M.C., Musso, T., Gusella, G.L., Longo, D.L., and Varesio, L.: Interleukin-2 and human monocyte activation. J. Leukoc. Biol. 57: 13-19, 1995. PMID: 7829965

480. Fenton, R.G. and Longo, D.L.: Editorial: Genetic instability and tumor cell variation: implications for immunotherapy. J. Natl. Cancer Inst. 87: 241-243, 1995. PMID: 7707413

481. Sharfman, W.H., Urba, W.J., Smith, J.W., II, Janik, J.E., Curti, B.D., Gause, B.L., Holmlund, J.T., Steis, R.G., Beauchamp, A.E., and Longo, D.L.: Phase I/II trial of 5-fluorouracil, leucovorin, zidovudine and dipyridamole for patients with metastatic colorectal cancer, renal cell carcinoma and malignant melanoma. Int. J. Oncol. 6: 579-583, 1995.

482. Wiltrout, R.H., Gregorio, T.A., Fenton, R.G., Longo, D.L., Ghosh, P., Murphy, W.J., and Komschlies, K.L.: Cellular and molecular studies in the treatment of murine renal cancer. Semin. Oncol. 22: 9-16, 1995. PMID: 7855624

483. Fischer, R.T., Longo, D.L., and Kenny, J.J.: A novel phosphocholine antigen protects both normal and X-linked immune deficient mice against Streptococcus pneumoniae: comparison of the 6-0-phosphocholine hydroxyhexanoate-conjugate with other phosphocholine-containing vaccines. J. Immunol. 154: 3373-3382, 1995. PMID: 7897220

484. Taub, D.D., Proost, P., Murphy, W.J., Anver, M., Longo, D.L., Van Damme, J., and Oppenheim, J.J.: Monocyte chemotactic protein-1 (MCP-1), -2, and -3 are chemotactic for human T lymphocytes. J. Clin. Invest. 95: 1370-1376, 1995. PMID: 7883984

485. Kwak, L.W., Taub, D.D., Duffey, P.L., Bensinger, W.I., Bryant, E.M., Reynolds, C.W., and Longo, D.L.: Transfer of myeloma idiotype-specific immunity from an actively immunised marrow donor. Lancet 345: 1016-1020, 1995. PMID: 7723498

486. Beckwith, M., Ruscetti, F.W., Sing, G.K., Urba, W.J., and Longo, D.L.: Anti-IgM induces transforming growth factor- sensitivity in a human B-lymphoma cell line: inhibition of growth is associated with a downregulation of mutant p53. Blood 85: 2461-2470, 1995. PMID: 7727777

487. Murphy, W.J., Rui, H., and Longo, D.L.: Effects of growth hormone and prolactin on immune development and function. Life Sci. 57: 1-14, 1995. PMID: 7596216

488. Fenton, R.G., Sznol, M., Luster, D.G., Taub, D.D., and Longo, D.L.: A phase I trial of B7-transfected or parental lethally irradiated allogeneic melanoma cell lines to induce cell-mediated immunity against tumor-associated antigen presented by HLA-A2 or HLA-A1 in patients with stage IV melanoma. NCI protocol T93-0161. BRMP protocol 9401. Hum. Gene Ther. 6: 87-106, 1995. PMID: 7703289

489. Li, C-C.H., O’Connell, C.D., Beckwith, M., and Longo, D.L.: Detection of p53 mutations in B cell non-Hodgkin’s lymphoma cell lines. Leukemia 9: 650-655, 1995. PMID: 7723400

490. Kaufman, D. and Longo, D.L.: Hodgkin’s disease. In Abeloff, M.D., Armitage, J.O., Lichter, A.S., and Niederhuber, J.E. (Eds.): Clinical Oncology. New York, Churchill Livingstone, 1995, pp. 2075-2107.

491. Kenny, J.J., Tucker, P.W., Claflin, L., Katsumata, M., Green, M., Reed, J., and Longo, D.L.: Analysis of antigen-driven positive and negative selection of phosphocholine-specific bone marrow B-cells. Curr. Top. Microbiol. Immunol. 194: 235-244, 1995. PMID: 7895495

492. Tortolani, P.J., Johnston, J.A., Bacon, C.M., McVicar, D.W., Shimosaka, A., Linnekin, D., Longo, D.L., and O’Shea, J.J.: Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2. Blood 85: 3444-3451, 1995. PMID: 7780132

493. Kenny, J.J., Stall, A.M., Fischer, R.T., Derby, E., Yang, M.C.W., Tucker, P.W., and Longo, D.L.: Ig2b transgenes promote B cell development but alternate developmental pathways appear to function in different transgenic lines. J. Immunol. 154: 5694-5705, 1995. PMID: 7751621

494. Turley, J.M., Funakoshi, S., Ruscetti, F.W., Kasper, J., Murphy, W.J., Longo, D.L., and Birchenall-Roberts, M.C.: Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: role for transforming growth factor . Cell Growth Differ. 6: 655-663, 1995. PMID: 7669719

495. Linnekin, D., Mou, S.M., Greer, P., Longo, D.L., and Ferris, D.K.: Phosphorylation of a Fes-related protein in response to granulocyte-macrophage colony stimulating factor. J. Biol. Chem. 270: 4950-4954, 1995. PMID: 7876270

496. Xu, L., Badolato, R., Murphy, W.J., Longo, D.L., Anver, M., Hale, S., Oppenheim, J.J., and Wang, J.M.: A novel biologic function of serum amyloid A. Induction of T lymphocyte migration and adhesion. J. Immunol. 155: 1184-1190, 1995. PMID: 7636186

497. Bosco, M.C., Pulkki, K., Rowe, T.K., Zea, A.H., Musso, T., Longo, D.L., Varesio, L., and Espinoza-Delgado, I.: IL-4 inhibits IL-2-induced tumoricidal activity and secretory functions of human monocytes. Modulation of IL-2 binding and IL-2 receptor  chain expression. J. Immunol. 155: 1411-1419, 1995. PMID: 7636206

498. Ochoa, A.C. and Longo, D.L.: Alterations of signal transduction in T cells from cancer patients. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): .
Important Advances in Oncology 1995. Philadelphia, J.B. Lippincott, 1995, pp. 43-54. PMID: 7672813

499. Gause, B.L. and Longo, D.L.: Lymphoma and Hodgkin’s disease. In Rich, R.R., Shearer, W.T., Strober, W., Fleisher, T.A., and Schwartz, B.D., (Eds.): Clinical Immunology: Principles and Practice, First Edition. St. Louis, Mosby-Year Book, 1995, pp. 1745-1767.

500. Zea, A.H., Longo, D.L., Finke, J.H., Bukowski, R.M.., and Ochoa, A.C.: Alterations in signal transduction in T cells from cancer patients. In Bukowski, R.M., Finke, J.H., and Klein, E.A. (Eds): Biology of Renal Cell Carcinoma. New York, Springer-Verlag, 1995, pp. 65-71.

501. Wiltrout, R.H., Ghosh, P., Franco, J.L., Mori, M., Fenton, R.G., Longo, D.L., Murphy, W.J., Grzegorzewski, K., Kelvin, D.J., and Komschlies, K.L.: Cellular and molecular considerations for the treatment of murine renal cancer. In Bukowski, R.M., Finke, J.H., and Klein, E.A. (Eds): Biology of Renal Cell Carcinoma. New York, Springer-Verlag, 1995, pp. 123-132.

502. Murphy, W.J., Funakoshi, S., Beckwith, M., Rushing, S.E., Conley, D.K., Armitage, R.J., Fanslow, W.C., Rager, H.C., Taub, D.D., Ruscetti, F.W., and Longo, D.L.: Antibodies to CD40 prevent Epstein-Barr virus-mediated human B-cell lymphomagenesis in severe combined immune deficient mice given human peripheral blood lymphocytes. Blood 86: 1946-1953, 1995. PMID: 7544649

503. Musso, T., Badolato, R., Longo, D.L., Gusella, G.L., and Varesio, L.: Leukemia inhibitory factor induces interleukin-8 and monocyte chemotactic and activating factor in human monocytes: differential regulation by interferon-. Blood 86: 1961-1967, 1995. PMID: 7655023

504. Hornung, R.L., Longo, D.L., Bowersox, O.C., and Kwak, L.W.: Tumor antigen-specific immunization of bone marrow transplantation donors as adoptive therapy against established tumor. J. Natl. Cancer Inst. 87: 1289-1296, 1995. PMID: 7544833

505. Franco, J.L., Ghosh, P., Wiltrout, R.H., Carter, C.R.D., Zea, A.H., Momozaki, N., Ochoa, A.C., Longo, D.L., Sayers, T.J., and Komschlies, K.L.: Partial degradation of T-cell signal transduction molecules by contaminating granulocytes during protein extraction of splenic T cells from tumor-bearing mice. Cancer Res. 55: 3840-3846, 1995. PMID: 7641202

506. Hornung, R.L., Longo, D.L., Gowda, V.L., and Kwak, L.W.: Induction of a CD8+ cytotoxic T lymphocyte response to soluble antigen given together with a novel muramyl dipeptide adjuvant, N-acetyl-D-glucosaminyl-(1-4)-N-acetylmuramyl-L-alanyl-D-isoglutamine (GMDP). Ther. Immunol. 2: 7-14, 1995. PMID: 7553072

507. Hamanaka, R., Smith, M.R., O’Connor, P.M., Maloid, S., Mihalic, K., Spivak, J.L., Longo, D.L., and Ferris, D.K.: Polo-like kinase is a cell cycle-regulated kinase activated during mitosis. J. Biol. Chem. 270: 21086-21091, 1995. PMID: 7673138

508. Esteva-Lorenzo, F.J., Janik, J.E., Fenton, R.G., Emslie-Smith, A., Engel, A.G., and Longo, D.L.: Myositis associated with interleukin-2 therapy in a patient with metastatic renal cell carcinoma. Cancer 76: 1219-1223, 1995. PMID: 8630901

509. Murphy, W.J., Raziuddin, A., Mason, L., Kumar, V., Bennett, M., and Longo, D.L.: NK cell subsets in the regulation of murine hematopoiesis. I. 5E6+ NK cells promote hematopoietic growth in H-2d strain mice. J. Immunol. 155: 2911-2917, 1995. PMID: 7673708

510. Ghosh, P., Komschlies, K.L., Cippitelli, M., Longo, D.L., Subleski, J., Ye, J., Sica, A., Young, H.A., Wiltrout, R.H., and Ochoa, A.C.: Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. J. Natl. Cancer Inst. 87: 1478-1483, 1995. PMID: 7674335

511. Li, C-C.H., Dai, R-M., and Longo, D.L.: Inactivation of NF-B inhibitor : ubiquitin-dependent proteolysis and its degradation product. Biochem. Biophys. Res. Commun. 215: 292-301, 1995. PMID: 7575604

512. Longo, D.L.: The REAL classification of lymphoid neoplasms: one clinician’s view. In DeVita, V.T., Jr., Hellman, S., and Rosenberg, S.A. (Eds.): Cancer: Principles and Practice of Oncology Updates, Fourth Edition, vol. 9. Philadelphia, Lippincott-Raven Publishers, 1995, pp. 1-12.

513. Bacon, C.M., Tortolani, P.J., Shimosaka, A., Rees, R.C., Longo, D.L., and O’Shea, J.J.: Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3. FEBS Lett. 370: 63-68, 1995. PMID: 7544303

514. Tian, Z-G., Longo, D.L., Funakoshi, S., Asai, O., Ferris, D.K., Widmer, M., and Murphy, W.J.: In vivo antitumor effects of unconjugated CD30 monoclonal antibodies on human anaplastic large-cell lymphoma xenografts. Cancer Res. 55: 5335-5341, 1995. PMID: 7585597

515. Tortolani, P.J., Lal, B.K., Riva, A., Johnston, J.A., Chen, Y-Q., Reaman, G.H., Beckwith, M., Longo, D., Ortaldo, J.R., Bhatia, K., McGrath, I., Kehrl, J., Tuscano, J., McVicar, D.W., and O’Shea, J.J.: Regulation of JAK3 expression and activation in human B cells and B cell malignancies. J. Immunol. 155: 5220-5226, 1995. PMID: 7594533

516. Zea, A.H., Curti, B.D., Longo, D.L., Alvord, W.G., Strobl, S.L., Mizoguchi, H., Creekmore, S.P., O’Shea, J.J., Powers, G.C., Urba, W.J., and Ochoa, A.C.: Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin. Cancer Res. 1: 1327-1335, 1995. PMID: 9815928

517. Linnekin, D., Keller, J.R., Ferris, D.K., Mou, S.M., Broudy, V., and Longo, D.L.: Stem cell factor induces phosphorylation of a 200 kDa protein which associates with c-kit. Growth Factors 12: 57-67, 1995. PMID: 8527164

518. Spence, S.E., Keller, J.R., Ruscetti, F.W., Czarra, K.T., Gooya, J.M., Funakoshi, S., Longo, D.L., and Murphy, W.J.: Engraftment of SCID mice by human bone marrow hematopoietic cells cultured in vitro: an in vivo model for human gene transfer. Leukemia 9: S43-S47, 1995. PMID: 7475312

519. Funakoshi, S., Beckwith, M., Fanslow, W., Longo, D.L., and Murphy, W.J.: Epstein-Barr virus-induced human B-cell lymphoma arising in huPBL-SCID chimeric mice: characterization and the role of CD40 stimulation in their treatment and prevention. Pathobiology 63: 133-142, 1995. PMID: 8821629

520. Kwak, L.W. and Longo, D.L.: Modern vaccine adjuvants. In Chabner, B.A. and Longo, D.L. (Eds.): Cancer Chemotherapy and Biotherapy: Principles and Practice, Second Edition. Philadelphia, Lippincott-Raven Publishers, 1996, pp. 749-763.

521. Janik, J.E., Miller, L.L., Longo, D.L., Powers, G.C., Urba, W.J., Kopp, W.C., Gause, B.L., Curti, B.D., Fenton, R.G., Oppenheim, J.J., Conlon, K.C., Holmlund, J.T., Sznol, M., Sharfman, W.H., Steis, R.G., Creekmore, S.P., Alvord, W.G., Beauchamp, A.E., and Smith, J.W., II: Phase II trial of interleukin 1 and indomethacin in treatment of metastatic melanoma. J. Natl. Cancer Inst. 88: 44-49, 1996. PMID: 8847725

522. Dunn, B.K. and Longo, D.L.: Lymphoma occurring in association with other diseases. In Wiernik, P.H., Kyle, R.A., and Dutcher, J.P. (Eds.): Neoplastic Diseases of the Blood. New York, Churchill Livingstone, 1996, pp. 963-997.

523. Beckwith, M., Fenton, R.G., Katona, I.M., and Longo, D.L.: Phosphatidylinositol-3-kinase activity is required for the anti-Ig-mediated growth inhibition of a human B-lymphoma cell line. Blood 87: 202-210, 1996. PMID: 8547643

524. Wang, J., Medeiros, L.J., Longo, D.L., Mansoor, A., Raffeld, M., Duffey, P.L., Jaffe, E.S., and Stetler-Stevenson, M.: Use of the polymerase chain reaction technique to determine c-myc expression in follicular center cell lymphoma. Diagn. Mol. Pathol. 5: 20-25, 1996. PMID: 8919541

525. Kopp, W.C., Urba, W.J., Rager, H.C., Alvord, W.G., Oppenheim, J.J., Smith II, J.W., and Longo, D.L.: Induction of interleukin 1 receptor antagonist after interleukin 1 therapy in patients with cancer. Clin. Cancer Res. 2: 501-506, 1996. PMID: 9816196

526. Taub, D.D., Longo, D.L., and Murphy, W.J.: Human interferon-inducible protein-10 induces mononuclear cell infiltration in mice and promotes the migration of human T lymphocytes into the peripheral tissues of human peripheral blood lymphocytes-SCID mice. Blood 87: 1423-1431, 1996. PMID: 8608232

527. Taub, D.D., Ortaldo, J.R., Turcovski-Corrales, S.M., Key, M.L., Longo, D.L., and Murphy, W.J.:  chemokines costimulate lymphocyte cytolysis, proliferation and lymphokine production. J. Leukoc. Biol. 59: 81-89, 1996. PMID: 8558072

528. Schwarzenberger, P., Spence, S., Lohrey, N., Kmiecik, T., Longo, D.L., Murphy, W.J., Ruscetti, F.W., and Keller, J.R.: Gene transfer of multidrug resistance into a factor-dependent human hematopoietic progenitor cell line: in vivo model for genetically transferred chemoprotection. Blood 87: 2723-2731, 1996. PMID: 8639888

529. Kwak, L.W., Pennington, R., and Longo, D.L.: Active immunization of murine allogeneic bone marrow transplant donors with B-cell tumor-derived idiotype: a strategy for enhancing the specific antitumor effect of marrow grafts. Blood 87: 3053-3060, 1996. PMID: 8639929

530. Taub, D.D., Turcovski-Corrales, S.M., Key, M.L., Longo, D.L., and Murphy, W.J.: Chemokines and lymphocyte activation I.  chemokines costimulate human T lymphocyte activation in vitro. J. Immunol. 156: 2095-2103, 1996. PMID: 8690897

531. Murphy, W.J., Tian, Z-G., Asai, O., Funakoshi, S., Rotter, P., Henry, M., Strieter, R.M., Kunkel, S.L., Longo, D.L., and Taub, D.D.: Chemokines and T lymphocyte activation II. Facilitation of human T cell trafficking in severe combined immunodeficiency mice. J. Immunol. 156: 2104-2111, 1996. PMID: 8690898

532. Levitsky, H.I., Montogomery, J., Ahmadzadeh, M., Staveley-O’Carroll, K.,
Guarnieri, F., Longo, D.L., and Kwak, L.W.: Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J. Immunol. 156: 3858-65, 1996. PMID: 8621924

533. Taub, D.D., Anver, M., Oppenheim, J.J., Longo, D.L., and Murphy, W.J.: T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo. J. Clin. Invest. 97: 1931-1941, 1996. PMID: 8621778

534. Funakoshi, S., Longo, D.L., and Murphy, W.J.: Differential in vitro and in vivo antitumor effects mediated by anti-CD40 and anti-CD20 monoclonal antibodies against human B-cell lymphomas. J. Immunother. 19: 93-101, 1996. PMID: 8732692

535. Curti, B.D., Urba, W.J., Longo, D.L., Janik, J.E., Sharfman, W.H., Miller, L.L., Cizza, G., Shimizu, M., Oppenheim, J.J., Alvord, W.G., and Smith II, J.W.: Endocrine effects of IL-1 and  administered in a phase I trial to patients with advanced cancer. J. Immunother. 19: 142-148, 1996. PMID: 8732697

536. Chertov, O., Michiel, D.F., Xu, L., Wang, J.M., Tani, K., Murphy, W.J., Longo, D.L., Taub, D.D., and Oppenheim, J.J.: Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J. Biol. Chem. 271: 2935-2940, 1996. PMID: 8621683

537. Longo, D.L.: The case against the routine use of radiation therapy in advanced stage Hodgkin’s disease. Cancer Invest. 14:353-360, 1996. PMID: 8689431

538. Longo, D.L.: Autografting for Hodgkin’s disease. In Carella, A.M. (Ed.): Autologous Stem Cell Transplantation: Biological and Clinical Results in Malignancies. United Kingdom, Harwood Academic Publishers, 1996, pp.347-353.

539. Murphy, W.J. and Longo, D.L.: NK cells in the regulation of hematopoiesis. ImmunoMethods 9: 344-351, 1996. PMID: 8812687

540. Longo, D.L.: Chemotherapy alone in the treatment of patients with early stage Hodgkin’s disease. Ann. Oncol. 7 (suppl 4): 85-89, 1996. PMID: 8836416

541. Newton, D.L., Pearson, J.W., Xue, Y., Smith, M.R., Fogler, W.E., Mikulski, S.M., Alvord, W.G., Kung, H-F., Longo, D.L., and Rybak, S.M.: Anti-tumor ribonuclease, combined with or conjugated to monoclonal antibody MRK16, overcomes multidrug resistance to vincristine in vitro and in vivo. Int. J. Oncol 8: 1095-1104, 1996.

542. Fisher, R.I., Magrath, I., and Longo, D.L.: Lymphomas: a clinical approach to the less common entities. ASCO Educational Booklet 301-322, 1996.

543. Rybak, S.M., Pearson, J.W., Fogler, W.E., Volker, K., Spence, S.E., Newton, D.L., Mikulski, S.M., Ardelt, W., Riggs, C.W., Kung, H.F., and Longo, D.L.: Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease. J. Natl. Cancer Inst. 88: 747-753, 1996. PMID: 8637029

544. Murphy, W.J., Taub, D.D., and Longo, D.L.: The huPBL-SCID chimera as a means to examine human immune function and activity in vivo. Semin. Immunol.8: 233-241, 1996. PMID: 8883146

545. Weiler, S.R., Mou, S., DeBerry, C.S., Ferris, D.K., Ruscetti, F., Keller, J.R., Longo, D.L., and Linnekin, D.: JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor. Blood 87: 3688-3693, 1996. PMID: 8611693

546. Kenny, J., Fischer, R.T., Lustig, A., Dintzis, H., Katsumata, M., Reed, J.C., and
Longo, D.L.: bcl-2 alters the antigen-driven selection of B cells in  but not in -only xid transgenic mice. J. Immunol.157: 1054-1061, 1996. PMID: 8751609

547. Gause, B.L., Sznol, M., Kopp W.C., Janik, J.E., Smith II, J.W., Steis, R.G., Urba, W.J., Sharfman, W., Fenton, R.G., Creekmore, S.P., Holmlund, J., Conlon, K.C., VanderMolen, L.A., and Longo, D.L.: Phase I study of subcutaneously administered interleukin-2 in combination with interferon alfa-2a in patients with advanced cancer. J. Clin. Oncol.14: 2234-2241, 1996. PMID: 8708712

548. Ortaldo, J.R., Mason, A.T., Longo, D.L., Beckwith, M., Creekmore, S.P., and McVicar, D.W.: T cell activation via the disialoganglioside GD3: analysis of signal transduction. J. Leuk. Biol. 60: 533-539, 1996. PMID: 8864139

549. Linnekin, D., Mou, S., DeBerry, C., Weiler, S., Ferris, D.K., Ruscetti, F., Keller, J.R., and Longo, D.L.: JAK2 is constitutively associated with c-Kit and is phosphorylated in response to stem cell factor. Acta Hematologica 95: 224-228, 1996. PMID: 8677747

550. Longo, D.L.: Lymphoma. Editorial Overview. Curr. Opin. Oncol. 8: 343-345, 1996.

551. Longo, D.L.: Immunotherapy for non-Hodgkin’s lymphoma. Curr. Opin. Oncol. 8: 353-359, 1996. PMID: 8914801

552. Curti, B.D., Ochoa, A.C., Urba, W.J., Alvord, G., Kopp, W.C., Powers, G.,
Hawk, C., Creekmore, S.P., Gause, B.L., Janik, J.E., Holmlund, J.T., Kremers, P., Fenton, R.G., Miller, L., Sznol, M., Smith II, J.W., Sharfman, W.H., and Longo, D.L.: Influence of interleukin-2 regimens on circulating populations of lymphocytes after adoptive transfer of anti-CD3-stimulated T cells: Results from a phase I trial in cancer patients. J. Immunother. 19: 296-308, 1996. PMID: 8877723

553. Longo, D.L.: Hodgkin’s disease. In Perry, M.C. (Ed.): The Chemotherapy Sourcebook, Second Edition. Baltimore, Williams & Wilkins, 1996, pp.1345-1359.

554. Gause, B.L. and Longo, D.L.: Treatment of relapsed Hodgkin’s disease. Bailliere’s Clin. Haematol. 9: 559-572, 1996. PMID: 8922246

555. Beckwith, M., Jorgensen, G., and Longo, D.L.: The protein product of the protooncogene c-cbl forms a complex with phosphatidylinositol 3-kinase p85 and CD19 in anti-IgM-stimulated human B lymphoma cells. Blood 88: 3502-3507, 1996. PMID: 8896416

556. Hiddemann, W., Longo, D.L., Coiffier, B., Fisher, R.I., Cabanillas, F. Cavalli, F., Nadler, L.M., DeVita, V.T., Lister, T.A., and Armitage, J.O.: Lymphoma classification–the gap between biology and clinical management is closing. Blood 88:
4085-4089, 1996. PMID: 8943841

557. Sznol, M., Carter, C.L., and Longo, D.L.: Principles of chemotherapy interactions with biological agents. In Schilsky, R.L., Milano, G.A., Ratain, M.J. (Eds.): Principles of Antineoplastic Drug Development and Pharmacology, New York, Marcel-Dekker Inc., 1996, pp.223-240.

558. Conlon, K.C., Anver, M.R., Longo, D.L., Ortaldo, J.R., and Murphy, W.J.: Adoptive immunotherapy involving recombinant human M-CSF and R24 anti-melanoma antibody induces human T-cell infiltration into human melanoma xenografts. J. Immunother. 19: 317-323, 1996. PMID: 8941871

559. Fenton, R.G., Steis, R.G., Madara, K., Zea, A.H., Ochoa, A.C., Janik, J.E., Smith, J.W. II, Gause, B.L., Sharfman, W.H., Urba, W.J., Hanna, M.G., DeJager, R.L., Coyne, M.X., Crouch, R.D., Gray, P., Beveridge, J., Creekmore, S.P., Holmlund, J.,
Curti, B.D., Sznol, M., and Longo, D.L.: A phase I randomized study of subcutaneous
adjuvant IL-2 in combination with an autologous tumor vaccine in patients with advanced renal cell carcinoma. J. Immunother. 19: 364-374, 1996. PMID: 8941876

560. Raziuddin, A., Longo, D.L., Mason L., Ortaldo, J.R., and Murphy, W.J.: Ly-49G2+ NK cells are responsible for mediating the rejection of H-2b bone marrow allografts in
mice. Int. Immunol. 8: 1833-1839, 1996. PMID: 8982767

561. Usui, N., Matsushima, K., Pilaro, A.M., Longo, D.L., and Wiltrout, R.H.: Antitumor
effects of human recombinant interleukin-1 and etoposide against human tumor cells: mechanism for synergism in vitro and activity in vivo. Biotherapy 9:199-208, 1996. PMID:
9012539

562. Longo, D.L., and Arun, B.: Cervical adenopathy: A clinical approach to diagnosis. Consultant 36-11: 2345-2352, 1996.

563. Kwak, L.W., and Longo, D.L.: Lymphomas. In Pinedo, H.M., Longo, D.L., and Chabner, B.A. (Eds.): Cancer Chemotherapy and Biological Response Modifiers Annual 16. Amsterdam, Elsevier Science Publishers B.V., 1996, pp. 376-440. PMID: 8639391

564. Longo, D.L.: Oncology. In Joyce, M. (Ed.): Encyclopedia of Science & Technology, 8th edition, vol. 12. New York, McGraw-Hill Publishing Company, 1997, pp. 369-376.

565. Ochoa, A.C., Zea, A.H., Ghosh, P., and Longo, D.L.: Signal transduction changes in T cells from patients with cancer. In Herzenberg, L.A., Weir, D.M., Herzenberg, L.A., Blackwell, C. (Eds.): Weir’s Handbook of Experimental Immunology, Fifth Edition. Cambridge, Blackwell Science, Inc., 1996, pp. 110.1-110.6.

566. Kwak, L.W., and Longo, D.L.: Biological response modifiers. In Magrath, I.T. (Ed.): The Non-Hodgkin’s Lymphomas, Second Edition. London, Arnold, 1997, pp. 699-714.

567. Sausville, E.A., and Longo, D.L.: Growth factors and growth factor inhibitors. In Teicher, B.A. (Ed): Cancer Therapeutics. Experimental and Clinical Agents. Totowa, N.J., Humana Press, 1997, pp.337-370.

568. Longo, D.L.: Lymphoid neoplasms: molecular biology. In Bertino, J.R. (Ed.): Molecular Biology of Cancer. San Diego, Academic Press, 1997, pp.1015-1030.

569. Curti, B.D., and Longo, D.L.: A brief history of immunologic thinking: is it time for yin and yang? In Adam JA, Bellomo N (Eds.): A Survey of Models for Tumor-Immune System Dynamics. Boston, Birkhauser, 1997, pp.1-12.

570. Curti, B.D., and Longo, D.L.: The cancer patient. In Parrillo, J.E. (Ed.): Current Therapy in Critical Care Medicine, Third Edition. St. Louis, Mosby-Year Book; Inc., 1997, pp. 368-373.

571. Fenton, R.G., and Longo, D.L.: Danger versus tolerance: paradigms for future studies of tumor-specific cytotoxic T lymphocytes. J. Natl. Cancer Inst. 89: 272-275, 1997. PMID: 9048827

572. Taub, D.D., Murphy, W.J., Asai, O., Fenton, R.G., Peltz, G., Key, M.L., Turcovski-Corrales, S., and Longo, D.L.: Induction of alloantigen-specific T cell tolerance through the treatment of T lymphocytes with the phosphatidylinositol-3-kinase inhibitor, wortmannin. J. Immunol. 158: 2745-2755, 1997. PMID: 9058809

573. Funakoshi, S., Taub, D.D., Asai, O., Hirano, A., Ruscetti, F.W, Longo, D.L., and Murphy, W.J.: Effects of CD40 stimulation in the prevention of human EBV-induced B-cell lymphomagenesis. Leuk. Lymphoma 24: 187-199, 1997. PMID: 9156649

574. Funakoshi, S., Taub, D.D., Anver, M.R., Raziuddin, A., Asai, O., Reddy, V., Rager, H., Fanslow, W.C., Longo, D.L., and Murphy, W.J.: Immunologic and hematopoietic effects of CD40 stimulation after syngeneic bone marrow transplantation in mice. J. Clin. Invest. 99: 484-491, 1997. PMID: 9022082

575. Saxton, M.L., Longo, D.L., Wetzel, H.E., Tribble, H, Alvord, W.G., Kwak, L.W., Leonard, A.S., Ullmann, C.D., Curti, B.D., and Ochoa, A.C.: Adoptive transfer of anti-CD3-activated CD4+ T cells plus cyclophosphamide and liposome-encapsulated interleukin-2 cure murine MC-38 and 3LL tumors and establish tumor-specific immunity. Blood 89: 2529-2536, 1997. PMID: 9116299

576. Bosco, M.C., Rottschafer, S., Taylor, L.S., Ortaldo, J.R., Longo, D.L., and Espinoza-Delgado, I.: The antineoplastic agent bryostatin-1 induces proinflammatory cytokine production in human monocytes: Synergy with interleukin-2 and modulation of interleukin-2 receptor  chain expression. Blood 89: 3402-3411, 1997. PMID: 9129048

577. Tiberghien, P., Cahn, Y., Brion, A., Deconinck, E., Racadot, E., Herve, P., Milpied, N., Lioure, B., Gluckman, E., Bordigoni, P., Jacob, W., Chiang, Y., Marcus, S., Reynolds, C., and Longo, D.: Clinical Protocol: Use of donor T-lymphocytes expressing herpes simplex thymidine kinase in allogeneic bone transplantation: A phase I-II study. Hum. Gene Ther. 8:615-624, 1997. PMID: 9095412

578. Uchiumi, T., Longo, D.L., and Ferris, D.K.: Cell cycle regulation of the human polo-like (PLK) promoter. J. Biol. Chem. 272: 9166-9174, 1997. PMID: 9083047

579. Correa, M.R., Ochoa, A.C., Ghosh, P., Mizoguchi, H., Harvey, L., and Longo, D.L.: Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J. Immunol. 158: 5292-5296, 1997. PMID: 9164948

580. Guo, W-X., Burger, A.M., Fischer, R.T., Sieckmann, D.G., Longo, D.L., and Kenny, J.J.: Sequence changes at the V-D junction of the VH1 heavy chain of anti-phosphocholine antibodies alter binding to and protection against Streptococcus pneumoniae. Int. Immunol. 9: 665-677, 1997. PMID: 9184912

581. Murphy, W.J., and Longo, D.L.: The potential role of NK cells in the separation of graft-versus-tumor effects from graft-versus-host disease after allogeneic bone marrow transplantation. Immunol. Rev. 157: 167-176, 1997. PMID: 9255629

582. Smith, M.R., Wilson, M.L., Hamanaka, R., Chase, D., Kung, H-f., Longo, D.L., and Ferris, D.K.: Malignant transformation of mammalian cells initiated by constitutive expression of the Polo-like kinase, Plk. Biochem. Biophys. Res. Commun. 234: 397-405, 1997. PMID:
9177283

583. Taub, D.D., Key, M.L., Longo, D.L., and Murphy, W.J.: Chemokine-induced human
lymphocyte infiltration and engraftment in huPBL-SCID mice. Methods Enzymol. 287: 265-291, 1997. PMID: 9330328

584. Ershler, W.B., and Longo, D.L.: The biology of aging: the current research agenda. Cancer 80: 1284-93, 1997. PMID: 9317181

585. Longo, D.L.: Lymphoma: Editorial overview. Curr. Opin. Oncol. 9: 389-391, 1997. PMID: 9327217

586. Bosco, M.C., Espinoza-Delgado, I., Rowe, T.K., Malabarba, M.G., Longo, D.L., and
Varesio, L.: Functional role for the myeloid differentiation antigen CD14 in the activation
of human monocytes by IL-2. J. Immunol. 159: 2922-2931, 1997. PMID: 9300716

587. Funakoshi, S., Hirano, A., Beckwith, M., Asai, O., Jorgensen, G., Tian, Z., Hornick J.L., Hu, P., Khawli, L.A., Epstein, A.L., Longo, D.L., and Murphy, W.J.: Antitumor effects of nonconjugated murine Lym-2 and human-mouse chimeric CLL-1 monoclonal antibodies against various human lymphoma cell lines in vitro and in vivo. Blood 90: 3160-3166, 1997. PMID: 9376598

588. Ershler, W.B., and Longo, D.L.: Aging and cancer: issues of basic and clinical science. J. Natl. Cancer Inst. 89: 1489-1497, 1997. PMID: 9337345

589. Longo, D.L., Glatstein, E., Duffey, P.L., Young, R.C., Ihde, D.C., Bastian, A.W., Wilson, W.H., Wittes, R.E., Jaffe, E.S., Hubbard, S.M., and DeVita, V.T., Jr.: Alternating MOPP and ABVD chemotherapy plus mantle-field radiation therapy in patients with massive mediastinal Hodgkin’s disease. J. Clin. Oncol. 15: 3338-3346, 1997. PMID: 9363863

590. Teruya-Feldstein, J., Jaffe, E.S., Burd, P.R., Kanegane, H., Kingma, D.W., Wilson, W.H., Longo, D.L., and Tosato, G.: The role of Mig, the monokine induced by interferon-g and IP-10, the interferon-g-inducible protein-10, in tissue necrosis and vascular damage associated with Epstein-Barr virus-positive lymphoproliferative disease. Blood 90: 4099-4105, 1997. PMID: 9354680

591. Linnekin, D., Mou, S., Deberry, C.S., Weiler, S.R., Keller, J.R., Ruscetti, F.W., and Longo, D.L.: Stem cell factor, the JAK-STAT pathway and signal transduction. Leukemia and Lymphoma 27: 439-444, 1997. PMID: 9477125

592. Sieckmann, D.G., Martin, E., Guelde, G., Longo, D.L., and Kenny, J.J.: Anti-idiotype monoclonal antibodies specific for the MOPC167 anti-phosphocholine transgene-encoded antibody. Hybridoma 16: 503-511, 1997. PMID: 9455702

593. Gause, B.L., Sharfman, W.H., Janik, J.E., Curti, B.D., Steis, R.G., Urba, W.J., Smith, J.W., II, Alvord, W.G., and Longo, D.L.: A phase II study of carboplatin, cisplatin, interferon-alpha, and tamoxifen for patients with metastatic melanoma. Cancer Invest. 16: 374-380, 1998. PMID: 9679527

594. The Editors: The practice of medicine. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 1-6.

595. Henry, P.H., and Longo, D.L.: Enlargement of lymph nodes and spleen. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 345-351.

596. Ihde, D.C., and Longo, D.L.: Presentations of the patient with cancer: solid tumors in adults. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 360-362.

597. Longo, D.L.: Approach to the patient with cancer. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 493-499.

598. Fenton, R.G., and Longo, D.L.: Cell biology of cancer. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 505-512.

599. Ruscetti, F.W., Keller, J.R., and Longo, D.L.: Hematopoiesis. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 634-638.

600. Longo, D.L.: Plasma cell disorders. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 712-718.

601. Fauci, A.S., and Longo, D.L.: The human retroviruses. In Fauci, A.S., Braunwald, E., Isselbacher, K.J., Wilson, J.D., Martin, J.B., Kasper, D.L., Hauser, S.L., and Longo, D.L. (Eds.): Harrison’s Principles of Internal Medicine, 14th Edition. New York, McGraw-Hill, 1998, pp. 1105-1111.

602. Raziuddin, A., Longo, D.L., Mason, L., Ortaldo, J.R., Bennett, M., and Murphy, W.J.: Differential effects of the rejection of bone marrow allografts by the depletion of activating versus inhibiting Ly-49 natural killer cell subsets. J. Immunol. 160: 87-94, 1998. PMID: 9551959

603. Little, R., Wittes, R.E., Longo, D.L., and Wilson, W.H.: Vinblastine for recurrent Hodgkin’s disease following autologous bone marrow transplant. J. Clin. Oncol. 16: 584-588, 1998. PMID: 9469345

604. Zea, A.H., Ochoa, M.T., Ghosh, P., Longo, D.L., Alvord, W.G., Valderrama, L., Falabella, R., Harvey, L.K., Saravia, N., Moreno, L.H., and Ochoa, A.C.: Changes in expression of signal transduction proteins in T lymphocytes of patients with leprosy. Infect. Immun. 66: 499-504, 1998. PMID: 9453602

605. Dai, R-M., Chen, E., Longo, D.L., Gorbea, C.M., and Li, C-C.H.: Involvement of valosin-containing protein, an ATPase co-purified with IB and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IB. J. Biol. Chem. 273: 3562-3573, 1998. PMID: 9452483

606. Yoe, J., Gause, B.L., Curti, B.D., Longo, D.L., Bagg, A., Kopp, W.C., and Janik, J.E.: Development of rheumatoid arthritis after treatment of large granular lymphocyte leukemia with deoxycoformycin. Am. J. Hematol. 57: 253-257, 1998. PMID: 9495380

607. Asai, O., Longo, D.L., Tian, Z.G., Hornung, R.L., Taub, D.D., Ruscetti, F.W., and Murphy, W.J.: Suppression of graft-versus-host disease and amplification of graft-versus-tumor effects by activated natural killer cells after allogeneic bone marrow transplantation. J. Clin. Invest. 101: 1835-1842, 1998. PMID: 9576746

608. Srivastava, R.K., Srivastava, A.R., Korsmeyer, S.J., Nesterova, M., Cho-Chung, Y.S., and Longo, D.L.: Involvement of microtubules in the regulation of bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol. Cell. Biol. 18: 3509-3517, 1998. PMID: 9584191

609. Tian, Z-G., Woody, M.A., Sun, R., Welniak, L.A., Raziuddin, A., Funakoshi, S., Tsarfaty, G., Longo, D.L., and Murphy, W.J.: Recombinant human growth hormone promotes hematopoietic reconstitution after syngeneic bone marrow transplantation in mice. Stem Cells 16: 193-199, 1998. PMID: 9617894

610. Spence, S.E., Keller, J.R., Ruscetti, F.W., McCauslin, C.S., Gooya, J.M., Funakoshi, S., Longo, D.L., and Murphy, W.J.: Engraftment of ex vivo expanded and cycling human cord blood hematopoietic progenitor cells in SCID mice. Exp. Hematol. 26: 507-514, 1998. PMID: 9620284

611. Nguyen, B.Y., Clerici, M., Venzon, D.J., Bauza, S., Murphy, W.J., Longo, D.L., Baseler, M., Gesundheit, N., Broder, S., Shearer, G., and Yarchoan, R.: Pilot study of the immunologic effects of recombinant human growth hormone and recombinant insulin-like growth factor in HIV-infected patients. AIDS 12: 895-904, 1998. PMID: 9631143

612. Longo, D.L.: Solving the puzzle of follicular lymphoma. Cancer J. Sci. Am. 4 (suppl. 2): S1-S4, 1998. PMID: 9672768

613. Chase, D., Feng, Y., Hanshew, B., Winkles, J.A., Longo, D.L., and Ferris, D.K.: Expression and phosphorylation of fibroblast-growth-factor-inducible kinase (Fnk) during cell-cycle progression. Biochem. J. 333: 655-660, 1998. PMID: 9677325

614. Curti, B.D., Ochoa, A.C., Powers, G.C., Kopp, W.C., Alvord, W.G., Janik, J.E., Gause, B.L., Dunn, B., Kopreski, M.S., Fenton, R., Zea, A., Dansky-Ullmann, C., Strobl, S., Harvey, L., Nelson, E., Sznol, M., and Longo, D.L.: Phase I trial of anti-CD3-stimulated CD4+ T cells, infusional interleukin-2, and cyclophosphamide in patients with advanced cancer. J. Clin. Oncol. 16: 2752-2760, 1998. PMID: 9704728

615. Longo, D.L.: Lymphoma: there’s something happening here. Curr. Opin. Oncol. 10: 375-376, 1998.

616. Longo, D.L.: Interferon toxicity worse in retrospect: impact on Q-TWiST? J. Clin. Oncol. 16: 3716-3718, 1998. PMID: 9817297

617. Murphy, W.J., Welniak, L.A., Taub, D.D., Wiltrout, R.H., Taylor, P.A., Vallera, D.A., Kopf, M., Young, H., Longo, D.L., and Blazar, B.R.: Differential effects of the absence of interferon-g and IL-4 in acute graft-vs-host disease after allogeneic bone marrow transplantation in mice. J. Clin. Invest. 102: 1742-1748, 1998. PMID: 9802888

618. Hasenclever, D., Diehl, V., Armitage, J.O., Assouline, D., Bjorkholm, M., Brusamolino, E., Canellos, G.P., Carde, P., Crowther, D., Cunningham, D., Eghbali, H., Ferme, C., Fisher, R.I., Glick J.H., Glimelius, B., Gobbi, P.G., Holte, H., Horning, S.E., Lister, T.A., Longo, D.L., Mandelli, F., Polliack, A., Proctor, S.J., Specht, L., Sweetenham, J.W., and Hudson, G.V.: A prognostic score for advanced Hodgkin’s disease. N. Engl. J. Med. 339: 1506-1514, 1998. PMID: 9819449

619. Chen, E., Hrdlickova, R., Nehyba, J., Longo, D.L., Bose, H.R. Jr., and Li, C-C.H.: Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathway. J. Biol. Chem. 273: 35201-35207, 1998. PMID: 9857058

620. Murphy, W.J., Funakoshi, S., Fanslow, W.C., Rager, H.C., Taub, D.D., and Longo, D.L.: CD40 stimulation promotes human secondary immunoglobulin responses in huPBL-SCID chimeras. Clin. Immunol. 90: 22-27, 1999. PMID: 9884349

621. Woody, M.A., Welniak, L.A., Richards, S., Taub, D.D., Tian, Z., Sun, R., Longo, D.L., and Murphy, W.J.: Use of neuroendocrine hormones to promote reconstitution after bone marrow transplantation. Neuroimmunomodulation 6: 69-80, 1999. PMID: 9876237

622. Longo, D.L., Duffey, P.L., Kopp, W.C., Heyes, M.P., Alvord, W.G., Sharfman, W.H., Schmidt, P.J., Rubinow, D.R., and Rosenstein, D.L.: Conditioned immune response to interferon- in humans. Clin. Immunol. 90: 173-181, 1999. PMID: 10080828

623. Srivastava, R.K., Srivastava, A., Cho-Chung, Y.S., and Longo, D.L.: Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells. Oncogene 18: 1755-1764, 1999. PMID: 10208436

624. Srivastava, R.K., Mi, Q.S., Hardwick, J.M., and Longo, D.L.: Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc. Natl. Acad. Sci. USA 96: 3775-3780, 1999. PMID: 10097113

625. Text Atlas of Lymphomas. Armitage, J.O., Cavalli, F., and Longo, D.L., authors. Martin Dunitz Ltd., London, 207pp, 1999.

626. Feng, Y., Hodge, D.R., Palmieri, G., Chase, D.L., Longo, D.L., and Ferris, D.K.: Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex. Biochem. J. 339: 435-442, 1999. PMID: 10191277

627. Hirano, A., Longo, D.L., Taub, D.D., Ferris, D.K., Young, L.S., Eliopoulos, A.G., Agathanggelou, A., Cullen, N., Macartney, J., Fanslow, W.C., and Murphy, W.J.: Inhibition of human breast carcinoma growth by a soluble recombinant human CD40 ligand. Blood 93: 2999-3007, 1999. PMID: 10216096

628. Bartlett, N.L., and Longo, D.L.: T-small lymphocyte disorders. Semin. Hematol. 36: 164-170, 1999. PMID: 10319385

629. Miller, L.L., Korn, E.L., Stevens, D.S., Janik, J.E., Gause, B.L., Kopp, W.C., Holmlund, J.T., Curti, B.D., Sznol, M., Smith, J.W. II, Urba, W.J., Donegan, S.E., Watson, T.M., and Longo, D.L.: Abrogation of the hematological and biological activities of the interleukin-3/granulocyte-macrophage colony-stimulating factor fusion protein PIXY321 by neutralizing anti-PIXY321 antibodies in cancer patients receiving high-dose carboplatin. Blood 93: 3250-3258, 1999. PMID: 10233876

630. Woody, M.A., Welniak, L.A., Sun, R., Tian, Z.G., Henry, M., Richards, S., Raziuddin, A., Longo, D.L., and Murphy, W.J.: Prolactin exerts hematopoietic growth-promoting effects in vivo and partially counteracts myelosuppression by azidothymidine. Exp. Hematol. 27: 811-816, 1999. PMID: 10340396

631. Srivastava, R.K., Srivastava, A.R., Cho-Chung, Y., and Longo, D.L.: Synergistic effects of retinoic acid and 8-chloro-adenosine-3′,5′-cyclic monophosphate on the regulation of
retinoic acid receptor  and apoptosis: involvement of mitochondria. Clin. Cancer Res. 5: 1892-1904, 1999. PMID: 10430097

632. Srivastava, R.K., Sollott, S.J., Khan, L., Hansford, R., Lakatta, E.G., and Longo, D.L.: Bcl-2 and Bcl-XL block thapsigargin-induced nitric oxide generation, c-Jun NH2-terminal kinase activity, and apoptosis. Mol. Cell. Biol. 19: 5659-5674, 1999. PMID: 10409755

633. Srivastava, R.K., Sasaki, C.Y., Hardwick, JM, and Longo, D.L.: Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription. J. Exp. Med. 190: 253-266, 1999. PMID: 10432288

634. Longo, D.L.: Lymphoma treatment: you have to admit it’s getting better. Curr. Opin. Oncol. 11: 319-321, 1999. PMID: 10505766

635. Bendandi, M., and Longo, D.L.: Biologic therapy for lymphoma. Curr. Opin. Oncol. 11: 343-350, 1999. PMID: 10505770

636. Bendandi, M., Gocke, C.D., Kobrin, C.B., Benko, F.A., Sternas, L.A., Pennington, R., Watson, T.M., Reynolds, C.W., Gause, B.L., Duffey, P.L., Jaffe, E.S., Creekmore, S.P., Longo D.L., and Kwak, L.W.: Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nature Medicine 5: 1171-1177, 1999. PMID: 10502821

637. Longo, D.L.: Follicular lymphoma. In: Foley, J.F., Vose, J.M., and Armitage, J.O. (Eds.): Current Therapy in Cancer, 2nd Edition. Philadelphia, W.B. Saunders, 1999, pp. 321-329.

638. Janik, J.E., Miller, L.L., Kopp, W.C., Taub, D.D., Dawson, D., Stevens, D., Kostboth, P., Curti, B.D., Conlon, K.C., Dunn, B.K., Donegan, S.E., Ullrich, R., Alvord, W.G., Gause, B.L., and Longo, D.L.: Treatment with tumor necrosis factor- and granulocyte-macrophage colony-stimulating factor increases epidermal Langerhans’ cell numbers in cancer patients. Clin. Immunol. 93: 209-221, 1999. PMID: 10600331

639. Kaufman, D., and Longo, D.L.: Hodgkin’s disease. In: Abeloff, M.D., Armitage, J.O., Lichter, A.S., and Niederhuber, J.E. (Eds.): Clinical Oncology, 2nd Edition. Philadelphia, Churchill-Livingstone, 2000, pp. 2620-2657.

640. Chase, D., Serafinas, C., Ashcroft, N., Kosinski, M., Longo, D., Ferris, D.K., and Golden, A.: The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans. Genesis 26: 26-41, 2000. PMID: 10660671

641. Arun, B., Curti, B.D., Longo, D.L., Stevens, D., Alvord, W.G., Gause, B.L., Watson, T., Kopp, W.C., and Janik, J.E.: Elevations in serum soluble interleukin-2 receptor levels predict relapse in patients with hairy cell leukemia. Cancer J. Sci. Am. 6: 21-24, 2000. PMID: 10696734

642. Dunn, B.K., and Longo, D.L.: Molecular biology and biological markers. In: Hunter, C.P., Johnson, K.A., and Muss, H.B. (Eds.): Cancer in the Elderly, New York, Marcel Dekker, 2000, pp. 69-121.

643. Murphy, W.J., and Longo, D.L.: Growth hormone as an immunomodulating agent. Immunol. Today 21: 211-213, 2000. PMID: 10877541

644. Kalechman, Y., Longo, D.L., Catane, R., Shani, A., Albeck, M., and Sredni, B.: Synergistic anti-tumoral effect of paclitaxel (taxol) + AS101 in a murine model of B16 melanoma: Association with ras-dependent signal transduction pathways. Int. J. Cancer 86: 281-288, 2000. PMID: 10738258

645. Kenny, J.J., Rezanka, L.J. Lustig, A., Fischer, R.T., Yoder, J., Marshall, S., and Longo, D.L.: Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors. J. Immunol. 164: 4111-4119, 2000. PMID: 10754305

646. Mi, Q-S., Zhou, L., Schulze, D.H., Fischer, R.T., Lustig, A., Rezanka, L.J., Donovan, D.M., Longo, D.L., and Kenny, J.J.: Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in the mouse. Proc. Natl. Acad. Sci. U.S.A. 97: 6031-6036, 2000. PMID: 11801665

647. Kenny, J.J., Derby, E.G., Yoder, J.A., Hill, S.A., Fischer, R.T., Tucker, P.W., Claflin, J.L., and Longo, D.L.: Positive and negative selection of antigen-specific B cells in transgenic mice expressing variant forms of the VH1 (T15) heavy chain. Int. Immunol. 12: 873-885, 2000. PMID: 10837415

648. Raziuddin, A., Bennett, M., Winkler-Pickett, R., Ortaldo, J.R., Longo, D.L., and Murphy, W.J.: Synergistic effects of in vivo depletion of Ly-49A and Ly-49G2 natural killer cell subsets in the rejection of H-2b bone marrow allografts. Blood 95: 3840-3844, 2000. PMID: 10845918

649. Longo, D.L., Duffey, P.L., Gribben, J.G., Jaffe, E.S., Curti, B.D., Gause, B.L., Janik, J.E., Braman V.M., Esseltine, D., Wilson, W.H., Kaufman, D, Wittes, R.E., Nadler, L.M., and Urba, W.J.: Combination chemotherapy followed by an immunotoxin (anti-B4-blocked ricin) in patients with indolent lymphoma: results of a phase II study. Cancer J. Sci. Am. 6: 146-150, 2000. PMID: 10882329

650. Longo, D.L.: Lymphomas: complexity, not chaos. Curr. Opin. Oncol. 12: 379-382, 2000.
PMID: 10975543

651. Kenny, J.J., Lustig, A., and Longo, D.L.: Positive selection of low affinity autoreactive B cells. Curr. Top. Microbiol. Immunol. 252: 39-45, 2000. PMID: 11125491

652. Sasaki, C.Y., Lin, H., Morin, P.J., and Longo, D.L.: Truncation of the extracellular region abrogates cell contact but retains the growth suppressive activity of E-cadherin. Cancer Res. 60: 7057-7065, 2000. PMID: 11156412

653. Alexandroff, A.B., Jackson, A.M., Paterson, T., Haley, J.L., Ross, J.A., Longo, D.L., Murphy, W.J., James, K., and Taub, D.D.: Role for CD40-CD40 ligand interactions in the immune response to solid tumours. Mol. Immunol. 37: 515-526, 2000. PMID: 11163401

654. Tiberghien, P., Ferrand, C., Lioure, B., Milpied, N., Angonin, R., Deconinck, E., Certoux, J-M., Robinet, E., Saas, P., Petracca, B., Juttner, C., Reynolds, C.W., Longo, D.L., Herve, P., and Cahn, J-Y.: Administration of herpes simplex–thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft. Blood 97: 63-72, 2001. PMID: 11133743

655. Longo, D.L.: Hodgkin’s disease: chemotherapy. In: Rakel, R.E., and Bope, E.T. (Eds.): Conn’s Current Therapy 2001, Philadelphia, W.B. Saunders, 2001, pp 429-435.

656. Murphy, W.J., and Longo, D.L.: Alternative strategies other than growth hormone for the treatment of immune diseases. Trends Immunol. 22: 15-16, 2001. PMID: 10877541

657. The Editors: The practice of medicine. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 1-5.

658. Adamson, J.W., and Longo, D.L.: Anemia and polycythemia. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 348-354.

659. Henry, P.H., and Longo, D.L.: Enlargement of lymph nodes and spleen. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 360-365.

660. Longo, D.L.: Approach to the patient with cancer. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 491-497.

661. Fenton, R.G., and Longo, D.L.: Cell biology of cancer. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 509-517.

662. Sausville, E.A., and Longo, D.L.: Principles of cancer treatment. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 530-547.

663. Perry, M.C., and Longo, D.L.: Late consequences of cancer and its treatment. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 650-653.

664. Armitage, J.O., and Longo, D.L.: Malignancies of lymphoid cells. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 715-727.

665. Longo, D.L.: Plasma cell disorders. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 727-733.

666. Fauci, A.S., and Longo, D.L.: The human retroviruses. In: Braunwald, E., Fauci, A.S., Kasper, D.L., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 15th Edition. New York, McGraw-Hill, 2001, pp. 1131-1135.

667. Feng, Y., Longo, D.L., and Ferris, D.K.: Polo-like kinase interacts with proteasomes and regulates their activity. Cell Growth Differ. 12: 29-37, 2001. PMID: 11205743

668. Janik, J.E., Miller, L.L., Korn, E.L., Stevens, D., Curti, B.D., Smith, J.W. II, Sznol, M., Conlon, K.C., Sharfman, W., Urba, W.J., Gause, B.L., and Longo, D.L.: A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma. Blood 97: 1942-1946, 2001. PMID: 11264156

669. Srivastava, R.K., Mattson, M.P., and Longo, D.L.: Cytoskeletal involvement in apoptosis. In: Mattson, M.P., Estus, S., and Rangnekar, V.M. (Eds.): Programmed Cell Death Volume I Cellular and Molecular Mechanisms, Amsterdam, Elsevier, 2001, pp. 237-267.

670. Westin, E.H., and Longo, D.L.: T-small cell disorders. Curr. Treat. Options Oncol. 2: 225-235, 2001. PMID: 12057122

671. Murphy, W.J., Koh, C.Y., Raziuddin, A., Bennett, M., and Longo, D.L.: Immunobiology of natural killer cells and bone marrow transplantation: merging of basic and preclinical studies. Immunol. Rev. 181: 279-289, 2001. PMID: 11513149

672. Westin, E.H., and Longo, D.L.: Lymphocytic lymphomas and Hodgkin’s disease. In: Austen, K.F., Frank, M.M., Atkinson, J.P., and Cantor, H. (Eds.): Samter’s Immunologic Diseases, 6th edition, Philadelphia, Lippincott Williams and Wilkins, 2001, pp. 359-379.

673. Curti, B.D., and Longo, D.L.: Intensive care of the cancer patient. In: Parrillo, J.E., and Dellinger, R.P. (Eds.): Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 2nd edition, St. Louis, Mosby, 2001, pp. 1439-1457.

674. Luo, Y., Long, J.M., Spangler, E.L., Longo, D.L., Ingram, D.K., and Weng, N-P.: Identification of maze learning-associated genes in rat hippocampus by cDNA microarray. J. Mol. Neurosci. 17: 127-134, 2001. PMID: 11859936

675. Nakamura, M., Ogawa, N., Shalabi, A., Maley, W.R., Longo, D., and Burdick, J.F.: Positive effect on T-cell regulatory apoptosis by mycophenolate mofetil. Clin. Transplant. 15 (suppl 6): 36-40, 2001. PMID: 11903384

676. Hu, L., Rezanka, L.J., Mi, Q.S., Lustig, A., Taub, D.D., Longo, D.L., and Kenny, J.J.: T15-idiotype-negative B cells dominate the phosphocholine binding cells in the preimmune repertoire of T15i knockin mice. J. Immunol. 168: 1273-1280, 2002. PMID: 11801665

677. Luo, Y., Long, J.M., Lu, C., Chan, S.L., Spangler, E.L., Masarucci, P., Raz, A., Longo, D.L., Mattson, M.P., Ingram, D.K., and Weng, N-P.: A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J. Neurochem. 80: 354-361, 2002. PMID: 11902125

678. Yang, F., Xi, X., Sharma, M., Sasaki, C.Y., Longo, D.L., Lim, B., and Sun, Z.: Linking -cateninto androgen-signaling pathway. J. Biol. Chem. 277: 11336-11344, 2002. PMID: 11792709

679. Mi, Q.S., Rezanka, L.J., Lustig, A., Zhou, L., Longo, D.L., and Kenny, J.J.: The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice. Eur. J. Immunol. 32: 1139-1146, 2002. PMID: 11932921

680. Wilson, W.H., Grossbard, M.L., Pittaluga, S., Cole, D., Pearson, D., Drbohlav, N., Steinberg, S.M., Little R.F., Janik, J., Gutierrez, M., Raffeld, M., Staudt, L., Cheson, B.D., Longo, D.L., Harris, N., Jaffe, E.S., Chabner, B.A., Wittes, R., and Balis, F.: Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood 99: 2685-2693, 2002. PMID: 11929754

681. Longo, D.L.: Genetic abnormalities in lymphoid malignancies. In: Vogelstein, B, and Kinzler, K.W. (Eds.): The Genetic Basis of Human Cancer, 2nd edition. New York, McGraw-Hill, 2002, pp. 785-801. (This chapter also appears in The Metabolic and Molecular Bases of Inherited Disease, 8th edition, Chapter 59.1)

682. Ghosh, P., Buchholz, M.A., Yano, S., Taub, D., and Longo, D.L.: Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Blood 99: 4517-4524, 2002. PMID: 12036883

683. Longo, D.L.: The Ng/Mauch article reviewed (published review of Controversies in early stage Hodgkin’s disease). Oncology 16: 610-612, 2002.

684. Rosenwald, A., Wright, G., Chan, W.C., Connors, J.M., Campo, E., Fisher, R.I., Gascoyne, R.D., Muller-Hermelink, H.K., Smeland, E.B., Giltnane, J.M., Hurt, E.M., Zhao, H., Averett, L., Yang, L., Wilson, W.H., Jaffe, E.S., Simon, R., Klausner, R.D., Powell, J., Duffey, P.L., Longo, D.L., Greiner T.C., Weisenburger, D.D., Sanger, W.G., Dave, B.J., Lynch, J.C., Vose, J., Armitage, J.O., Montserrat, E., Lopez-Guillermo, A., Grogan, T.M., Miller, T.P., LeBlanc, M., Ott, G., Kvaloy, S., Delabie, J., Holte, H., Krajci, P., Stokke, T., and Staudt, L.M. for the Lymphoma/Leukemia Molecular Profiling Project (listed as one of 30 coauthors based on contributing clinical data on 78 of the 240 subjects): The use of molecular profiling to predict survival after chemotherapy for diffuse large B-cell lymphoma. N. Engl. J. Med. 348: 1937-1947, 2002. PMID: 12075054

685. Szocinski, J.L., Khaled, A.R., Hixon, J., Halverson, D., Funakoshi, S., Fanslow, W.C., Boyd, A., Taub, D.D., Durum, S.K., Siegall, C.B., Longo, D.L., and Murphy, W.J.: Activation-induced cell death of aggressive histology lymphomas by CD40 stimulation: induction of bax. Blood 100: 217-223, 2002. PMID: 12070030

686. Longo, D.L.: DR’s orders: human antibody kills tumors by direct signaling. Nature Medicine 8: 781-783, 2002. PMID: 12152028

687. Longo, D.L.: Lymphoma, non-Hodgkin’s. In: Bertino J.R. (Ed.): Encyclopedia of Cancer, 2nd edition, San Diego, Academic Press, 2002, volume 3, pp 67-75.

688. Raziuddin, A., Longo, D.L., Bennett, M., Winkler-Pickett, R., Ortaldo, J.R., and Murphy, W.J.: Increased bone marrow allograft rejection by depletion of donor NK cells expressing inhibitory Ly49 NK receptors for donor class I antigens. Blood 100: 3026-3033, 2002. PMID: 12351417

689. Espinoza-Delgado, E., and Longo, D.L.: Non-Hodgkin’s lymphoma. In: Laughlin, M.J. and Lazarus, H.M. (Eds.): Allogeneic Stem Cell Transplantation: Clinical Research and Practice, Totowa, N.J., Humana Press, 2003, pp 83-99.

690. Shack, S., Wang, X-T., Kokkonen, G.C., Gorospe, M., Longo, D.L., and Holbrook, N.J.: Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol. Cell. Biol. 23: 2407-2414, 2003. PMID: 12640124

691. Ferrucci, L., Guralnik, J.M., Cavazzini, C., Bandinelli, S., Lauretani, F., Bartali, B., Repetto, L., and Longo, D.L.: The frailty syndrome: a critical issue in geriatric oncology. Crit. Rev. Oncol./Hematol. 46: 127-137, 2003. PMID: 12711358

692. Artz, A.S., Ershler, W.B., and Longo, D.L.: Pneumococcal vaccination and revaccination of older adults. Clin. Microbiol. Rev. 16: 308-318, 2003. PMID: 12692100

693. Longo, D.L.: Radiation therapy in the treatment of Hodgkin’s disease–do you see what I see? J. Natl. Cancer Inst. 95: 928-929, 2003. Response: Re: Radiation therapy in the treatment of Hodgkin’s disease–do you see what I see? J. Natl. Cancer Inst. 96: 236-237, 2004. PMID: 12837820

694. Yano, S., Ghosh, P., Kusaba, H., Buchholz, M., and Longo, D.L.: Effect of promoter methylation on the regulation of IFN-g gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 171: 2510-2516, 2003. PMID: 12928400

695. Longo, D.L.: Immunology of aging. In: Paul, W.E. (Ed.) Fundamental Immunology, 5th edition, Philadelphia, Lippincott Williams and Wilkins, 2003, pp. 1043-1075.

696. Sharov, A.A., Piao, Y., Matoba, R., Dudekula, D.B., Qian, Y., VanBuren, V., Falco, G., Martin, P.R., Stagg, C.A., Bassey, U.C., Wang, Y., Carter, M.G., Hamatani, T., Aiba, K., Akutsu, H., Sharova, L., Tanaka, T.S., Kimber, W.L., Yoshikawa, T., Jaradat, S.A., Pantano, S., Nagaraja, R., Boheler, K.R., Taub, D., Hodes, R.J., Longo, D.L., Schlessinger, D., Keller, J., Klotz, E., Kelsoe, G., Umezawa, A., Vescovi, A.L., Rossant, J., Kunath, T., Hogan, B.L., Curci, A., D’Urso, M., Kelso, J., Hide, W., and Ko, M.S.: Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 1: 410-419, 2003. PMID: 14691545

697. Dunn, B.K. and Longo, D.L.: Lymphomas in other diseases. In: Wiernik, P.H., Goldman, J.M., Dutcher, J.P., and Kyle R.A. (Eds.) Neoplastic Diseases of the Blood, 4th edition, Cambridge, Cambridge University Press, 2003, pp. 862-917.

698. Sredni, B., Weil, M., Khomenok, G., Lebenthal, H, Teitz, S., Mardor, Y., Ram, Z., Orenstein, A., Kershenovich, A., Michowiz, S., Cohen, Y.I., Rappoport, Z.H., Freidkin, I., Albeck, M., Longo, D.L., and Kalechman, Y.: Ammonium trichloro(dioxoethylene-o,o’)tellurate (AS101) sensitizes tumors to chemotherapy by inhibiting the tumor interleukin 10 autocrine loop. Cancer Res. 64: 1843-1852, 2004. PMID: 14996748

699. Muss, H.B., and Longo, D.L.: Introduction: Cancer in the elderly. Semin. Oncol. 31: 125-127, 2004.

700. Westin, E.H., and Longo, D.L.: Lymphoma and myeloma in older patients. Semin. Oncol. 31: 198-205, 2004. PMID: 15112150

701. Takahashi, K., Reynolds, M., Ogawa, N., Longo, D.L., and Burdick, J.: Augmentation of T-cell apoptosis by immunosuppressive agents. Clin. Transplant. 18 (suppl 12): 72-75, 2004. PMID: 15217415

702. Yuan, J.H., Feng, Y., Fisher, R.H., Maloid, S., Longo, D.L., and Ferris, D.K.: Polo-like kinase 1 inactivation following mitotic DNA damaging treatments is independent of ataxia telagiectasia mutated kinase. Mol. Cancer Res. 2: 417-426, 2004. PMID: 15280449

703. O’Farrell, T.J., Ghosh, P., Dobashi, N., Sasaki, C.Y., and Longo, D.L.: Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res. 64: 8199-8207, 2004. PMID: 15548685

704. Longo, D.L.: Hodgkin disease: the sword of Damocles resheathed. Blood 104: 3418, 2004.

705. Adamson, J.W. and Longo D.L.: Anemia and polycythemia. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 329-336.

706. Henry, P.H., and Longo, D.L.: Enlargement of lymph nodes and spleen. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 343-348.

707. Longo, D.L.: Approach to the patient with cancer. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 435-441.

708. Fenton, R.G. and Longo, D.L.: Cancer cell biology and angiogenesis. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 453-464.

709. Sausville, E.A. and Longo, D.L.: Principles of cancer treatment: surgery, chemotherapy, and biologic therapy. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 464-482.

710. Perry, M.C. and Longo, D.L.: Late consequences of cancer and its treatment. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 583-586.

711. Armitage, J.O. and Longo, D.L.: Malignancies of lymphoid cells. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 641-655.

712. Longo, D.L. and Anderson, K.C.: Plasma cell disorders. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 656-662.

713. Longo, D.L. and Fauci, A.S.: The human retroviruses. In: Kasper, D.L., Braunwald, E., Fauci, A.S., Hauser, S.L., Longo, D.L., and Jameson, J.L. (Eds.): Harrison’s Principles of Internal Medicine, 16th Edition. New York, McGraw-Hill, 2005, pp. 1071-1075.

714. Kusaba, H., Ghosh, P., Derin, R., Buchholz, M., Sasaki, C., Madara, K., and Longo, D.L.: Interleukin-12-induced interferon- production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J. Biol. Chem. 280: 1037-1043, 2005. PMID: 15522880

715. Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D.D., Guralnik, J.M., and Longo, D.L.: The origins of age-related pro-inflammatory state. Blood 105: 2294-2299, 2005. PMID: 15572589

716. Longo, D.L.: The Ganti/Bociek/Bierman et al. article reviewed. Oncology 19: 235-239, 2005.

717. Sakatani, T., Kaneda, A., Iacobuzio-Donahue, C.A., Carter, M.G., Witzel, S.D., Okano, H., Ko, M.S., Ohlsson, R., Longo, D.L., and Feinberg, A.P.: Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science 307: 1976-1978, 2005. PMID: 15731405

718. Taub, D.D., and Longo, D.L.: Insights into thymic aging and regeneration. Immunol. Rev. 205: 72-93, 2005. PMID: 15882346

719. Longo, D.L.: Closing in on a killer: anemia in elderly people. J. Gerontol. A Biol. Sci. Med. Sci. 60: 727-728, 2005. PMID: 15983174

720. Ershler, W.B., Sheng, S., McKelvey, J., Artz, A.S., Denduluri, N., Tecson, J., Taub, D.D., Brant, L.J., Ferrucci, L., and Longo, D.L.: Serum erythropoietin and aging: a longitudinal analysis. J. Am. Geriatr. Soc. 53: 1360-1365, 2005. PMID: 16078962

721. Gulmann, C., Espina, V., Petricoin, E., III, Longo, D.L., Santi, M., Knutsen, T., Raffeld, M., Jaffe, E.S., Liotta, L.A, and Feldman, A.L.: Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin. Cancer Res. 11:5847-5855, 2005. PMID: 16115925

722. Sasaki, C.Y., Barberi, T.J., Ghosh, P., and Longo, D.L.: Phosphorylation of RelA/p65 on serine 546 defines an -independent NF-B pathway. J. Biol. Chem. 280: 34528-34547, 2005. PMID: 16105840

723. Longo, D.L.: Chimera: from bane to blessing. Blood 106: 1890-1891, 2005.

724. Longo, D.L.: Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J. Natl. Cancer Inst. 97: 1394-1395, 2005. PMID: 16204683

725. Ferrucci, L., Guralnik, J.M., Woodman, R.C., Bandinelli, S., Lauretani, F., Corsi, A.M., Chaves, P.H., Ershler, W.B., and Longo, D.L.: Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am. J. Med. 118:1288.e11-e19, 2005. PMID: 16271918

726. Rezanka, L.J., Kenny, J.J., and Longo D.L.: 2 BCR or not 2 BCR–receptor dilution: a unique mechanism for preventing the development of holes in the protective B cell repertoire. Immunobiology 210: 769-774, 2005. PMID: 16325496

727. Lee, G.D., Longo, D.L., Wang, Y., Rifkind, J.M., Abdul-Raman, L., Mamczarz, J.A., Duffy, K.B., Spangler, E.L., Taub, D.D., Mattson, M.P., and Ingram, D.K.: Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin. Cancer Res. 12: 198-205, 2006. PMID: 16397043

728. Longo, D.L.: Pernicious anemia and other megaloblastic anemias. In: Rakel, R.E., Bope, E.T. (Eds): Conn’s Current Therapy 2006. Philadelphia, Saunders Elsevier, 2006, pp. 482-487.

729. Rezanka, L.J., Kenny, J.J., and Longo, D.L.: Dual isotype expressing B cells (+/+) arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice. Cell. Immunology 238: 38-48, 2006. PMID: 16458869

730. McHutchison, J.G., Manns, M.P., and Longo, D.L.: Definition and management of anemia in patients infected with hepatitis C virus. Liver Int. 26: 389-98, 2006. PMID: 16629641

731. Maggio, M., Guralnik, J.M., Longo, D.L., and Ferrucci, L.: Interleukin-6 in aging and chronic disease: a magnificent pathway. J. Gerontol. A Biol. Sci. Med. Sci 61: 575-584, 2006. PMID: 16799139

732. Ferrucci, L., Maggio, M., Bandinelli, S., Basaria, S., Lauretani, F., Ble, A., Valenti, G., Ershler, W.B., Guralnik, J.M., and Longo, D.L.: Low testosterone levels and the risk of anemia in older men and women. Arch. Intern. Med. 166: 1380-1388, 2006. PMID: 16832003

733. Ershler, W.B., and Longo, D.L.: A report card for geriatric oncology: borderline pass, improvement needed. J. Gerontol. A Biol. Sci. Med. Sci. 61: 688, 2006. PMID: 16870629

734. Lee, G.D., Ingram, D.K., and Longo, D.L.: Cancer chemotherapy and cognitive function in rodent models: memory impairment induced by cyclophosphamide in mice. Clin. Cancer Res. 12: 5000-5001, 2006. PMID: 16914590

735. Feng, Y., Yuan J.H., Maloid, S.C., Fisher, R., Copeland, T.D., Longo, D.L., Conrads, T.P., Veenstra, T.D., Ferris, A., Hughes, S., Dimitrov, D.S., and Ferris, D.K.: Polo-like kinase 1-mediated phosphorylation of the GRP-binding protein Ran is important for bipolar spindle formation. Biochem. Biophys. Res. Commun. 349: 144-152, 2006. PMID: 16930555

736. Longo, D.L.: Idiotype vaccination in follicular lymphoma: knocking on the doorway to cure. J. Natl. Cancer Inst. 98: 1263-1265, 2006. PMID: 16985240

737. Zou, S., Sinclair, J., Wilson, M.A., Carey, J.R., Liedo, P., Oropeza, A., Kalra, A., de Cabo, R., Ingram, D.K., Longo, D.L., and Wolkow, C.A.: Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech. Ageing Dev. 128: 222-226, 2007. PMID: 17169403

738. Annunziata, C.M., and Longo, D.L.: Lymphoma. Hodgkin. In: Boyiadzis, M.M., Lebowitz, P.F., Frame, J.N., and Fojo, T. (Eds): Hematology-Oncology Therapy. New York, McGraw-Hill, 2007, pp282-307.

739. Sredni, B., Geffen-Aricha, R., Duan, W., Albeck, M., Shalit, F., Lander, H.M., Kinor, N., Sagi, O., Albeck, A., Yosef, S., Brodsky, M., Sredni-Kenigsbuch, D., Sonino, T., Longo, D.L., Mattson, M.P., and Yadid, G.: Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson’s disease models. FASEB J. 21: 1870-1883, 2007. PMID: 17314138

740. Berner, V., Liu, H., Zou, Q., Alderson, L.L., Sun, K., Weiss, J.M., Back, T.C., Longo, D.L., Blazar B.R., Wiltrout, R.H., Welniak, L.A., Redelman, D., and Murphy, W.J.: Interferon- mediates CD4+ T-cell loss and impairs secondary antitumor responses after successful initial immunotherapy. Nature Med. 13: 354-360, 2007. PMID: 17334371

741. Ferrucci, L., Guralnik, J.M., Bandinelli, S., Semba, R.D., Lauretani, F., Corsi, A., Ruggiero, C., Ershler, W.B., and Longo, D.L.: Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br. J. Haematol. 136: 849-855, 2007. PMID: 17341272

742. Chen, G., Ghosh, P., Osawa, H., Sasaki, C.Y., Rezanka, L., Yang, J., O’Farrell, T.J., and Longo, D.L.: Resistance to TGF-1 correlated with aberrant expression of TGF-receptor II in human B-cell lymphoma cell lines. Blood 109: 5301-5307, 2007. PMID: 17339425

743. Stote, K.S., Baer, D.J., Spears, K., Paul, D.R., Harris, G.K., Rumpler, W.V., Strycula, P., Najjar, S.S., Ferrucci, L., Ingram, D.K., Longo, D.L., and Mattson, M.P.: A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am. J. Clin. Nutr. 85: 981-988, 2007. PMID: 17413096

744. Lustig, A., Weeraratna, A.T., Wood, W.W. III, Teichberg, D., Bertak, D., Carter, A., Poosala, S., Firman, J., Becker, K.G., Zonderman, A.B., Longo, D.L., and Taub, D.D.: Transcriptome analysis of age-, gender-, and diet-associated changes in murine thymus. Cell. Immunol. 245: 42-61, 2007. PMID: 17499630

745. Hayun, M., Okun, E., Hayun, R., Gafter, U., Albeck, M., Longo, D.L., and Sredni, B.: Synergistic effect of AS101 and bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model. Leukemia 21: 1504-1513, 2007. PMID: 17508000

746. Brodsky, M., Yosef, S., Galit, R., Albeck, M., Longo, D.L., Albeck, A., and Sredni, B.: The synthetic tellurium compound, AS101, is a novel inhibitor of IL-1 converting enzyme. J. Interferon Cytokine Res. 27: 453-462, 2007. PMID: 17572009

747. Longo, D.L.: Watch out, MF! Blood 110: 1708-1709, 2007.

748. Mattison, J.A., Ottinger, M.A., Powell, D., Longo, D.L., and Ingram, D.K.: Endometriosis: clinical monitoring and treatment procedures in Rhesus monkeys. J. Med. Primatol. 36: 391-398, 2007. PMID: 17976046

749. Heltemes-Harris, L.M., Gearhart, P.J., Ghosh, P., and Longo, D.L.: Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol. Immunol. 45: 1799-1806, 2007.
PMID: 17983655

750. Xu, X., Zhan, M., Duan, W., Prabhu, V., Brenneman, R., Wood, W., Firman, J., Li, H., Zhang, P., Ibe, C., Zonderman, A.B., Longo, D.L., Poosala, S., Becker, K.G., and Mattson, M.P.: Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake, and gender. Genome Biol. Nov 7; 8(11):R234, 2007. PMID: 17988385

751. Carlson, O., Martin, B., Stote, K.S., Golden, E., Maudsley, S., Najjar, S.S., Ferrucci, L., Ingram, D.K., Longo, D.L., Rumpler, W.V., Baer, D.J., Egan, J., and Mattson, M.P.: Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism 56: 1729-1734, 2007. PMID: 17998028

752. Sasaki, C.Y., Slemenda, C.F., Ghosh, P., Barberi, T.J., and Longo, D.L.: Traf1 induction and protection from tumor necrosis factor by nuclear factor p65 is independent of serine 536 phosphorylation. Cancer Res. 67:11218-11226, 2007. PMID: 18056447

753. Kaneda, A., Wang, C.J., Cheong, R., Timp, W., Onyango, P., Wen, B., Iacobuzio-Donahue, C.A., Ohlsson, R., Andraos, R., Pearson, M.A., Sharov, A.A., Longo, D.L., Ko, M.S.H., Levchenko, A., and Feinberg, A.P.: Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc. Natl. Acad. Sci. U.S.A. 104:20926-20931, 2007. PMID: 18087038

754. Huang, M-C., Liao, J-J., Bonasera, S., Longo, D.L., and Goetzl, E.J.: Nuclear factor-B-dependent reversal of aging-induced alterations in T cell cytokines. FASEB J. 22: 2142-2150, 2008. PMID: 18267981

755. Pearson, K.J., Lewis, K.N., Price, N.L., Chang, J.W., Perez, E., Cascajo, M.V., Tamashiro, K.L., Poosala, S., Csiszar, A., Ungvari, Z., Kensler, T.W., Yamamoto, M., Egan, J.M., Longo, D.L., Ingram D.K., Navas, P., and de Cabo, R.: Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc. Natl. Acad. Sci. U.S.A. 105: 2325-2330, 2008. PMID: 18287083

756. Anderson, D.E., Fedorova, O.V., Morrell, C.H., Longo, D.L., Kashkin, V.A., Metzler, J.D., Bagrov, A.Y., and Lakatta, E.G.: Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294: R1248-R1254, 2008. PMID: 18287222

757. The Editors: The practice of medicine. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 1-6.

758. Adamson, J.W. and Longo, D.L.: Anemia and polycythemia. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 355-363.

759. Henry, P.H. and Longo, D.L.: Enlargement of lymph nodes and spleen. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 370-375.

760. Scadden, D.T. and Longo, D.L.: Hematopoietic stem cells. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 430-434.

761. Longo, D.L.: Approach to the patient with cancer. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 479-486.

762. Fenton, R.G. and Longo, D.L.: Cancer cell biology and angiogenesis. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 498-513.

763. Sausville, E.A., and Longo, D.L.: Principles of cancer treatment. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 514-533.

764. Longo, D.L.: Malignacies of lymphoid cells. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 687-700.

765. Munshi, M.C., Longo, D.L., and Anderson, K.C.: Plasma cell disorders. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 700-707.

766. Longo, D.L. and Fauci, A.S.: The human retroviruses. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. 1132-1137.

767. Longo, D.L.: Atlas of hematology and analysis of peripheral blood smears. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. e77-e88.

768. Longo, D.L.: Thymoma. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. e89-e90.

769. Perry, M.D. and Longo, D.L.: Late consequences of cancer and its treatment. In: Fauci, A.S., Braunwald, E., Kasper, D.L., Hauser, S.L., Longo, D.L., Jameson, J.L., and Loscalzo, J. (Eds.): Harrison’s Principles of Internal Medicine, 17th Edition. New York, McGraw-Hill, 2008, pp. e91-e96.

770. Curti, B.D. and Longo, D.L.: Intensive care of the cancer patient. In: Parrillo, J.E. and Dellinger, R.P. (Eds.): Critical Care Medicine: Principles of Diagnosis and Management in the Adult, 3rd Edition. Philadelphia, Mosby-Elsevier, 2008, pp. 1677-1695.

771. Ershler, W.B., Ferrucci, L., and Longo, D.L.: Hutchinson-Gilford progeria syndrome. N. Engl. J. Med. 358: 2409-2410, 2008. PMID: 18509130

772. Sharov, A.A., Falco, G., Piao, Y., Poosala, S., Becker, K.G., Zonderman, A.B., Longo, D.L., Schlessinger, D., and Ko, M.S.H.: Effects of aging and calorie restriction on the global gene expression profiles of testis and ovary. BMC Biology 6: 24, 2008. PMID: 18522719

773. Ruggiero, C., Metter, E.J., Melenovsky, V., Cherubini, A., Najjar, S.S., Ble, A., Senin, U., Longo, D.L., and Ferrucci, L.: High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging. J. Gerontol. A Biol. Sci. Med. Sci. 63: 698-706, 2008. PMID: 18693224

774. Fedorova, O.V., Simbirtsev, A.S., Kolodkin, N.I., Kotov, A.Y., Agalakova, N.I., Kashkin, V.A., Tapilskaya, N.I., Bzhelyansky, A., Reznik, V.A., Frolova, E.V., Nikitina, E.R., Budny, G.V., Longo, D.L., Lakatta, E.G., and Bagrov, A.Y.: Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J. Hypertens. 26: 2414-2425, 2008. PMID: 19008721

775. Semba, R.D., Patel, K.V., Sun, K., Guralnik, J.M., Ersher, W.B., Longo, D.L., and Ferrucci, L.: Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and anemia in adults: the Baltimore Longitudinal Study of Aging. J. Am. Geriatr. Assoc. 56: 2145-2147, 2008. PMID: 19016950

776. Taub, D.D., Ershler, W.B., Janowski, M., Artz, A., Key, M.L., McKelvey, J., Muller, D., Moss, B., Ferrucci, L., Duffey, P.L., and Longo, D.L.: Immunity from smallpox vaccine persists for decades: a longitudinal study. Am. J. Med. 121: 1058-1064, 2008. PMID:
19028201

777. Dissanayake, S.K., Olkhanud, P.B., O’Connell, M.P., Carter, A., French, A.D., Camilli, T.C., Emeche, C.D., Hewitt, K.J., Rosenthal, D.T., Leotlela, P.D., Wade, M.S., Yang, S.W., Brant, L., Nickoloff, B.J., Messina, J.L., Biragyn, A., Hoek, K.S., Taub, D.D., Longo, D.L., Sondak, V.K., Hewitt, S.M., and Weeraratna, A.T.: Wnt5a regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 68: 10205-10214, 2008. PMID: 19074888

778. Patel, K.V., Ferrucci, L., Ershler, W.B., Longo, D.L., and Guralnik, J.M.: Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch. Intern. Med. 169: 515-523, 2009. PMID: 19273783

779. Patel, K.V., Longo, D.L., Ershler, W.B., Yu, B., Semba, R.D., Ferrucci, L., and Guralnik, J.M.: Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up. Br. J. Haematol. 145: 514-523, 2009. PMID: 19344387

780. Longo, D.L.: Hodgkin’s lymphoma: an overview. Cancer J. 15: 114-116, 2009. PMID: 19390305

781. Seam, P., Janik, J.E., Longo, D.L., and DeVita, Jr., V.T.: Role of chemotherapy in Hodgkin’s lymphoma. Cancer J. 15:150-154, 2009. PMID: 19390311

782. De Siervi, A., De Luca, P., Moiola, C., Gueron, G., Tongbai, R., Chandramouli, G.V., Haggerty, C., Dzekunova, I., Petersen, D., Kawasaski, E., Kil, W.J., Camphausen, K., Longo, D., and Gardner, K.: Identification of new Rel/NFκB by focused genome location analysis.
Cell Cycle 8: 2093-2100, 2009. PMID: 19502793

783. Longo, D.L.: Telomere dynamics in aging: Much ado about nothing? J. Gerontol. A Biol. Sci. Med. Sci. 64A: 963-964, 2009. PMID: 19505961

784. Longo, D.L.: Late effects from radiation therapy: The hits just keep on coming. J. Natl. Cancer Inst. 101: 904-905, 2009. PMID 19535779

785. Prabhakar, M., Ershler, W.B., and Longo, D.L.: Bone marrow, thymus and blood: changes across the life span. Aging Health 5:385-393, 2009.

786. Pierorazio, P.M., Ferrucci, L., Kettermann, A., Longo, D.L., Metter, E.J., and Carter, H.B.: Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging. BJU Int. 105: 824-829, 2010 PMID: 19751256

787. Nishiyama, A., Xin, L., Sharov, A.A., Tomas, M., Mowrer, G., Meyers, E., Piao, Y., Mehta, S., Yee, S., Nakatake, Y., Stagg, C., Sharova, L., Correa-Cerro, L.S., Bassey, U., Hoang, H., Kim, E., Tapnio, R., Qian, Y., Magaraja, R., Goldberg, I., Wang, W., Longo, D.L., Schlessinger, D., and Ko, M.S.: Uncovering early response gene regulatory networks in embryonal stem cells by sytematic induction of transcription factors. Cell Stem Cell 5:420-433, 2009. PMID: 19796622

788. Tanaka, T., Roy, C.N., Yao, W., Matteini, A., Semba, R.D., Arking, D., Walston, J.D., Fried, L.P., Singleton, A., Guralnik, J., Abecasis, G.R., Bandinelli, S., Longo, D.L., and Ferrucci, L.: A genome-wide association analysis of serum iron concentrations. Blood 115: 94-96, 2010. PMID: 19880490

789. Byun, J.S., Wong, M.M., Cui, W., Idelman, G., Li, Q., De Siervi, A., Bilke, S., Haggerty, C.M., Player, A., Wang, Y.H., Thirman, M.J., Kaberlein, J.J., Petrovas, C., Koup, R.A., Longo, D., Ozato, K. and Gardner, K.: Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proc. Natl. Acad. Sci. USA 106: 19286-19291, 2009. PMID: 19880750

790. Patel, K.V., Semba, R.D., Ferrucci, L., Newman, A.B., Fried, L.P., Wallace, R.B., Bandinelli, S., Phillips, C.S., Yu, B., Connelly, S., Shlipak, M.G., Chaves, P.H., Launer, L.J., Ershler, W.B., Harris, T.B., Longo, D.L., and Guralnik, J.M.: Red cell distribution width and mortality in older adults: a meta-analysis. J. Gerontol. A Biol. Med. Sci. 65: 258-265, 2010. PMID: 19880817

791. Saito, T., Sasaki, C.Y., Rezanka, L.J., Ghosh, P., and Longo, D.L.: p52-independent nuclear translocation of RelB promotes LPS-induced attachment. Biochem. Biophys. Res. Commun. 391: 235-241, 2010. PMID: 19903458

792. Murphy, W.J., Artz, A.S., Champlin, R.E., Koreth, J., and Longo, D.L.: Blood stem cell transplantation in older patients. Biol. Blood Marrow Transplant. 15: 1638-1639, 2009. PMID: 19911448

793. De Siervi, A., De Luca, P., Byun, J.S., Di, L.J., Fufa, T., Haggerty, C.M., Vazquez, E., Moiola, C., Longo, D.L., and Gardner, K.: Transcriptional autoregulation by BRCA1. Cancer Res. 70: 532-542, 2010. PMID: 20068145

794. Ferrucci L., Semba, R.D., Guralnik, J.M., Ershler, W.B., Bandinelli, S., Patel, K.V., Sun, K., Woodman, R.C., Andrews, N.C., Cotter, R.J., Ganz, T., Nemeth, E., and Longo, D.L.: Proinflammatory state, hepcidin and anemia in older persons. Blood 115: 3810-3819, 2010. PMID: 20081092

795. Huang, M.C., Patel, K., Taub, D.D., Longo, D.L., and Goetzl, E.J.: Human CD4-8- T cells are a distinctive immunoregulatory subset. FASEB J. 24: 2558-2566, 2010. PMID: 20154266

796. Tita-Nwa, F., Bos, A., Adjei, A., Ershler, W.B., Longo, D.L., and Ferrucci, L.: Correlates of D-dimer in older persons. Aging Clin. Exp. Res. 22: 20-23, 2010. PMID: 20305364

797. Goetzl, E.J., Huang M.C., Kon, J., Patel, K., Schwartz, J.B., Fast, K., Ferrucci, L., Madara, K., Taub, D.D., Longo, D.L.: Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 24: 3580-3589, 2010. PMID: 20453111

798. Gibbs, J.R., van der Brug, M.P., Hernandez, D.G., Traynor, B.J., Nalls, M.A., Lai, S.L., Arepalli, S., Dillman, A., Rafferty, I.P., Troncoso, J, Johnson R., Zielke, H.R., Ferrucci, L., Longo, D.L., Cookson, M.R., and Singleton, A.B.: Abundant quantitative triat loci exist for DNA methylation and gene expression in human brain. PLoS Genetics 6: e1000952, 2010. PMID: 20485568

799. Taub, D.D., Murphy, W. J., and Longo, D.L.: Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr. Opin. Pharmacol. 10: 408-424, 2010. PMID: 20595009

800. Longo, D.L. New therapies for castration-resistant prostate cancer. N. Engl. J. Med. 363: 479-481, 2010. PMID: 20818868

801. Alley, D.E., Metter, E.J., Griswold, M.E., Harris, T.B., Simonsick, E.M., Longo, D.L., and Ferrucci, L.: Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men. Am. J. Epidemiol. 172: 558-565, 2010. PMID: 20682520

802. Ershler, W.B., and Longo, D.L.: Hematology in older persons. In: Kaushansky, K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT (Eds), Williams Hematology, 8th edition. McGraw-Hill, New York, 2010, pp115-26.

803. Sasaki, C.Y., Ghosh, P., and Longo, D.L.: Recruitment of RelB to the Csf2 promoter enhances RelA-mediated transcription of granulocyte-macrophage colony-stimulating factor. J. Biol. Chem. 286: 1093-1102, 2011. PMID: 21071440

804. Melloni, C., Rao, S.V., Povsic, T.J., Melton, L., Kim, R.J., Kilaru, R., Patel, M.R., Talan, M., Ferrucci, L., Longo, D.L., Lakatta, E.G., Najjar, S.S., and Harrington, R.A.: Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial. Am. Heart. J. 160: 795-803.e2, 2010. PMID: 21095264

805. Di, L.J., Fernandez, A.G., De Siervi, A., Longo, D.L., and Gardner, K.: Transcriptional regulation of BRCA1 expression by a metabolic switch. Nat. Struct. Mol. Biol. 17: 1406-1413, 2010. PMID: 21102443

806. Huang, M.C., Greig, N.H., Luo, W., Tweedie, D., Schwartz, J.B., Longo, D.L., Ferrucci, L., Ershler, W.B., and Goetzl, E.J.: Preferential enhancement of older human T cell cytokine gernation, chemotaxis, proliferation, and survival by lenalidomide. Clin. Immunol. 138: 201-211, 2011. PMID: 21130040

807. Chen, G., Ghosh, P., and Longo, D.L.: Distinctive mechanism for sustained TGF-signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF- receptors. Mol. Cancer Res. 9: 78-87, 2011. PMID: 21131601

808. Brant, L.J., Ferrucci, L., Sheng, S.L., Concin, H., Zonderman, A.B., Kelleher, C.C., Longo, D.L., Ulmer, H. and Strasak, A.M.: Gender differences in the accuracy of time-dependent blood pressure indices for prediction coronary heart disease: a random-effects modeling approach. Gend. Med. 7: 616-627, 2010. PMID: 21195361

809. Ershler, W.B., and Longo, D.L.: Hematology in older persons. In: Kaushansky, K, Lichtman MA, Beutler E, Kipps TJ, Seligsohn U, Prchal JT (Eds), Williams Hematology, 8th edition. McGraw-Hill, New York, 2010, pp115-26.

810. Pichler, I., Minelli, C., Sanna, S., Tanaka, T., Schwienbacher, C., Naitza, S., Porcu, E., Pattaro, C., Busonero, F., Zanon, A., Maschio, A., Melville, S.A., Grazia Piras, M., Longo, D.L., Guralnik, J., Hernandez, D., Bandinelli, S., Aigner, E., Murphy, A.T., Wroblewski, V., Marroni, F., Theurl, I., Gnewuch, C., Schadt, E., Mitterer, M., Schlessinger D., Ferrucci, L., Witcher, D.R., Hicks, A.A., Weiss, G., Uda, M., and Pramstaller, P.P.: Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum. Mol. Genet. 20: 1232-1240, 2011. PMID: 21208937

811. Hernandez, D.G., Nalls, M.A., Gibbs, J.R., Arepalli, S., van der Brug, M., Chong, S., Moore, M., Longo, D.L., Cookson, M.R., Traynor, B.J., and Singleton, A.B.: Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum. Mol. Genet. 15: 1164-1172, 2011. PMID: 21216877

812. Reiter, D.A., Roque, R.A., Lin, P.C., Irrechukwu, O., Doty, S., Longo, D.L., Pleshko, N., and Spencer, R.G. Mapping proteoglycan-bound water in cartilage: improved specificity of matrix assessment using multiexponential tranverse relaxation analysis. Magn. Reson. Med. 65: 377-384, 2011. PMID: 21264931

813. Chabner, B.A., Barnes, J, Neal, J., Olson, E., Mujagic, H., Sequist, L, Wilson, W., Longo, D.L., Mitsiadis, C., and Richardson, P.: Targeted therapies: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines. In: Brunton, L., Chabner, B., and Knollman B. eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 12th edition, McGraw-Hill, New York, 2011, pp. 1731-53.

814. Dixit, V.D., Yang, H., Sayeed, K.S., Stote, K.S., Rumpler, W.V., Baer, D.J., Longo, D.L., Mattson, M.P., and Taub, D.D.: Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J. Inflamm. 8: 6, 2011. PMID: 21385360

815. Najjar, S.S., Rao, S.V., Melloni, C., Raman, S.V., Povsic, T.J., Melton, L., Barsness, G.W., Prather, K., Heitner, J.F., Kilaru, R., Gruberg, L., Hasselblad, V., Greenbaum, A.B., Patel, M., Kim, R.J., Talan, M., Ferrucci, L., Longo, D.L., Lakatta, E.G., and Harrington, R.A.; REVEAL Investigators. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA 305: 1863-1872, 2011. PMID: 21558517

816. Munk, R.B., Sugiyama, K., Ghosh, P., Sasaki, C.Y., Rezanka, L., Banerjee, K., Takahashi, H., Sen, R., and Longo, D.L.: Antigen-independent IFN- production by human naïve CD4 T cells activated by IL-12 plus IL-18. PLoS One 6: e18553, 2011. PMID: 21572994

817. Okada, Y., Hirota, T., Kamatani, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Higasa, K., Yamguchi-Kabata, Y., Hosono, N., Nalls, M.A., Chen, M.H., van Rooij, F.J., Smith, A.V., Tanaka, T., Couper, D.J., Zakai, N.A., Ferrucci, L., Longo, D.L., Hernandez, D.G., Witteman, J.C., Harris, T.B., O’Donnell, C.J., Ganesh, S.K, Matsuda, K., Tsunoda, T., Tanaka, T., Kubo, M., Nakamura, Y., Tamari, M, Yamamoto, K., and Kamatani, N. Idnetification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet. 7: 31002067, 2011. PMID: 21738478

818. Nalls, M.A., Couper, D.J., Tanaka, T., van Rooij, F.J, Chen, M.H., Smith, A.V., Toniolo, D., Zakai, N.A., Yang, Q., Greinacher, A., Wood, A.R., Garcia, M., Gasparinie, P., Liu, Y., Lumley, T., Folsom, A.R., Reiner, A.P., Gieger, C., Lagou, V., Felix, J.F., Volzke, H., Gouskova, N.A., Biffi, A., Doring, A., Volker, U., Chong, S., Wiggins, K.L., Rendon, A., Dehghan, A., Moore, M., Taylor, K., Wilson, J.G., Lettre, G., Hofman, A., Bis, J.C., Pirastu, N., Fox, C.S., Meisinger, C., Sambrook J., Arepalli, S., Nauck, M., Prokisch, H., Stephens, J., Glazer, N.L., Cupples, L.A., Okada, Y., Takahashi, A., Kamatani, Y., Matsuda, K., Tsunoda, T., Tanaka, T., Kubo, M., Mangino, M., Oostra, B.A., Thein, S.L., Coresh, J., Wichmann, H.E., Menzel, S., Lin, J., Pistis, G., Uitterlinden, A.G., Spector, T.D., Teumer, A., Eiriksdottir, G., Gudnason, V., Bandinelli, S., Frayling, T.M., Chakravarti, A., van Duijn, C.M., Melzer, D., Ouwehand, W.H., Levy, D., Boerwinkles, E., Singleton, A.B., Hernandez, D.G., Longo, D.L., Soranzo, N., Witteman, J.C., Psaty, B.M., Ferrucci, L., Harris, T.B., O’Donnell, C.J., and Ganesh, S.K. PLoS Genet. 7: 31002113, 2011. PMID: 21738480

819. Urba, W.J., and Longo, D.L.: Redirecting T cells. N. Engl. J. Med. 365: 754-757, 2011. PMID: 21830939

820. Jacobsen, C.A., and Longo, D.L.: Management of early-stage Hodgkin’s lymphoma. PPO Updates 25:#2, 1-8, 2011.

821. Long, J.M., Lee, G.D., Kelley-Bell, B., Spangler, E.L., Perez, E.J., Longo, D.L., de Cabo, R., Zou, S., and Rapp, P.R.: Preserved learning and memory following 5-fluororuacil and cyclophosphamide treatment in rats. Pharmacol. Biochem. Behav. 100: 205-211, 2011. PMID: 21875615

822. Munk, R., Ghosh, P., Ghosh, M.C., Saito, T., Xu, M., Carter, A., Indig, F., Taub, D.D., and Longo, D.L.: Involvement of mTOR in CXCL12-mediated T-cell signaling and migration. PLoS One 6: e24667, 2011. PMID: 21931802

823. Hesdorffer, C.S., Malchinkhuu, E., Biragyn, A., Mabrouk, O.S., Kennedy, R.T., Madara, K., Taub, D.D., Longo, D.L., Schwartz, J.B., Ferrucci, L., and Goetzl, E.J.: Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB J. 26: 1301-10, 2012. PMID: 22121051

824. The Editors: The practice of medicine. In: Harrison’s Principles of Internal Medicine, 18th
Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J.,
editors, McGraw-Hill, New York, 2012, p2-9.

825. Adamson, J.W. and Longo, D.L.: Anemia and polycythemia. In: Harrison’s Principles of
Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L.,
Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.448-457.

826. Henry, P.H., and Longo, D.L.: Enlargement of lymph nodes and spleen. In: Harrison’s
Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L.,
Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012 p465-471.

827. Scadden, D.T. and Longo, D.L.: Hematopoietic stem cells. In: Harrison’s Principles of
Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L.,
Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p539-543.

828. Longo, D.L.: Approach to the patient with cancer. In: Harrison’s Principles of Internal
Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.646-654.

829. Longo, D.L.: Cancer cell biology and angiogenesis. In: Harrison’s Principles of Internal
Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.672-688.

830. Sausville, E.A., and Longo, D.L.: Principles of cancer treatment. In: Harrison’s
Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p689-711.

831. Jameson, J.L., and Longo, D.L.: Paraneoplastic syndromes: endocrinologic/hematologic.
In: Harrison’s Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.826-832.

832. Freter, C.E., and Longo, D.L.: Late consequences of cancer and its treatment. In:
Harrison’s Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.838-843.

833. Longo, D.L.: Malignancies of lymphoid cells. In: Harrison’s Principles of Internal
Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.919-935.

834. Munshi, N.D., Longo, D.L., and Anderson, K.C.: Plasma cell disorders. In: Harrison’s
Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.936-944.

835. Longo, D.L., and Fauci, A.S.: The human retroviruses. In: Harrison’s Principles of
Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, p.1500-1505.

836. Longo, D.L.: Neoplasia during pregnancy. In: Harrison’s Principles of Internal Medicine,
18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, chapter e6.

837. Longo, D.L.: Atlas of hematology and analysis of peripheral blood smears. In: Harrison’s
Principles of Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, chapter e17.

838. Longo, D.L.: Thymoma. In: Harrison’s Principles of Internal Medicine, 18th Edition,
Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, chapter e20.

839. Longo, D.L.: Less common hematologic malignancies. In: Harrison’s Principles of
Internal Medicine, 18th Edition, Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson J.L, Loscalzo, J., editors, McGraw-Hill, New York, 2012, chapter e21.

840. Sun, K., Alvarez, M., Ames, E., Barao, I., Chen, M., Longo, D.L., Redelman, D., and Murphy, W.J.: Mouse NK cell-mediated rejection of bone marrow allografts exhibits patterns consistent with Ly49 subset licensing. Blood 119: 1590-8, 2012. PMID: 22184406

841. Jacobson, C.A., and Longo, D.L.: Follicular lymphoma: to treat or not to treat is no longer the question. J. Natl. Cancer Inst. 104: 3-5, 2012. PMID: 22190632

842. Sredni, B, and Longo, D.L.: Cancer immunotherapy: Are we there yet? Semin. Cancer Biol. 22: 1-2, 2012. PMID: 22240249

843. Tietze, J.K., Wilkins, D.E., Sckisel, G.D., Bouchlaka, M.N., Alderson, K.L., Weiss, J.M., Ames, E., Bruhn, K.W., Craft, N., Wiltrout, R.H., Longo, D.L., Lanier, L.L., Blazer, B.R., Redelman, D., and Murphy, W.J. Delineation of antigen-specific and antigen-nonspecific CD8+ memory T-cell responses after cytokine-based cancer immunotherapy. Blood 119: 3073-83, 2012. PMID: 22251483

844. Biragyn, A., and Longo, D.L.: Neoplastic “Black Ops”: cancer’s subversive tactics in overcoming host defenses. Semin. Cancer Biol. 22: 50-9, 2012. PMID: 22257681

845. Naitza, S., Porcu, E., Steri, M., Taub, D.D., Mulas, A., Xiao, X., Strait, J., Dei, M, Lai, S., Busonero, F., Maschio, A., Usala, G., Zoledwiewska, M., Sidore, C., Zara, I., Pitzalis, M., Loi, A., Virdis, F., Piras, R., Deidda, F., Whalen, M.B., Crisponi, L., Concas, A., Podda, C., Uzzau, S., Scheet, P., Longo, D.L., Lakatta E, Abecasis, G.R., Cao, A., Schlessinger, D., Uda, M., Sanna S., Cucca, F.: A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 8:e1002480, 2012. PMID: 22291609

846. Correa-Cerro, L.S., Piao, Y., Sharov, A.A., Nishiyama, A., Cadet, J.S., Yu, H., Sharova, L.V., Xin, L., Hoang, H.G., Thomas, M., Qian, Y., Dudekula, D.B., Meyers, E., Binder, B.Y., Mowrer, G., Bassey, U., Longo, D.L., Schlessinger D., and Ko, M.S.; Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci. Rep. 1: 167, DOI: 10.1038/srep00167, 2011. PMID: 22355682

847. Longo, D.L.: Tumor heterogeneity and personalized medicine. N. Engl. J. Med. 366: 956-7, 2012. PMID: 22397658

848. Gottesman, R.F., Sojkova, J., Beason-Held, L.L., An, Y., Longo, D.L., Ferrucci, L., and Resnick, S.M.: Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Stuy of Aging. J. Gerontol. A Biol. Sci. Med. Sci. 67: 963-9, 2012. PMID: 22552368

849. Chen, G., Ghosh, P., O’Farrell, T., Munk, R., Rezanka, L.J., Sasaki, C.Y., and Longo, D.L.: TGF-beta1 suppresses growth of B-cell lymphoma cells by p14ARF-dependent regulation of mutant p53. J. Biol. Chem. 287: 23184-95, 2012. PMID: 22621932

850. Mattison, J.A., Roth, G.S., Beasley, T.M., Tilmont, E.M., Handy, A.M., Herbert, R.L., Longo, D.L., Allison, D.B., Young, J.E., Bryant, M., Barnard, D., Ward, W.F., Qi, W., Ingram D.K., and De Cabo, R.: Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 489: 318-21, 2012. PMID: 22932268

851. Longo, D.L., Fauci, A.S., Kasper, D.L., Hauser, S.L., Jameson, J.L., and Loscalzo, J. editors: Harrison’s Manual of Medicine, 18th edition, McGraw-Hill, New York, 2012.

852. Smith, T.J., and Longo, D.L.: Talking to patients about dying. N. Engl. J. Med. 367: 1651-2, 2012. PMID: 23094729; Letters, N. Engl. J. Med. 368: 481, 2013. PMID: 23373069

853. Longo, D.L.: Treatment of advanced Hodgkin lymphoma: the more things change, the more they stay the same. J. Clin. Oncol. 31: 660-2, 2013. PMID: 23196927
854. Maggio, M., Snyder, P.J., Ceda, G.P., Milaneschi, Y., Luci, M., Cattabiani, C., Masoni, S., Vignali, A., Volpi, R., Lauretani, F., Peachey, H., Valenti, G., Cappola, A.R., Longo, D.L., and Ferrucci, L.: Is the haematopoietic effect of testosterone mediated by erythropoietin? The results of a clinical trial in older men. Andrology 1: 24-8, 2013. PMID: 23258626

855. Gamaldo, A.A., Ferrucci, L., Rifkind, J., Longo, D.L., and Zonderman, A.B.: Relationship between mean corpuscular volume and cognitive performance in older adults. J. Am. Geriatr. Soc. 61: 84-9, 2013. PMID: 23301873

856. Crosslin, D.R., McDavid, A., Weston, N., Zheng, X., Hart, E., de Andrade, M., Kullo, I.J., McCarty, C.A., Doheny, K.F., Pugh, E., Kho, A., Hayes, M.G., Ritchie, M.D., Saip, A., Crawford, D.C., Crane, P.K., Newton, K., Carrell, D.S., Gallego, C.J., Nalls, M.A.,Li, R., Mirel, D.B., Crenshaw, A., Couper, D.J., Tanaka, T., van Rooij, F.J., Chen, M.H., Smith, A.V., Zakal, N.A., Yango, Q., Garcia, M., Liu, Y., Lumley, T., Folsom, A.R., Reiner, A.P., Gudnason, V., Bandinelli, S., Frayling, T.M., Chakravarti, A., van Duijn, C.M., Melzer, D., Levy, D., Boerwinkle, E., Singleton, A.B., Hernandez, D.G., Longo, D.L., Witteman, J.C., Psaty, B.M., Ferrucci, L., Harris, T.B., O’Donnell, C.J., Ganesh, S.K.; CHARGE Hematology Working Group, Larson, E.B., Carlson, C.S., Jarvik, G.P.; The electronic Medical Records and Genomics (eMERGE) Network. Genetic variation associated with circulating monocyte count in the eMERGE Network. Hum. Mol. Gen. 22: 2119-27, 2013. PMID: 23314186

857. Nishiyama, A., Sharov, A.A., Piao, Y., Amano, M., Amano, T., Hoang, H.G., Binder, B.Y., Tapnio, R., Bassey, U., Malinou, J.N., Correa-Cerro, L.S., Yu, H., Xin, L., Meyers, E., Zalzman, M., Nakatake, Y., Stagg, C., Sharova, L., Qian, Y., Dudekula, D., Sheer, S., Cadet, J.S., Hirata, T., Yang, H.T., Goldberg, I., Evans, M.K., Longo, D.L., Schlessinger, D., and Ko, M.S. Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci. Rep. 3: 1390, 2013. Doi: 10.1038/srep01390. PMID: 23462645.

858. Longo, D.L., editor, Harrison’s Hematology and Oncology, 2nd edition, McGraw-Hill, New York, 2013.

859. Longo, D.L., Fauci, A.S., editors, Harrison’s Gastroenterology and Hepatology, 2nd edition, McGraw-Hill, New York, 2013.

860. Sungur, C.M., Tang-Feldman, Y.J., Ames, E., Alvarez, M., Chen, M., Longo, D.L., Pomeroy, C., and Murphy, W.J. Murine natural killer cell licensing and regulation by T regulatory cells in viral responses. Proc. Natl. Acad. Sci. U.S.A. 110: 7401-6, 2013. PMID: 23589894

861. Sutin, A.R., Zonderman, A.B., Uda, M., Deiana, B., Taub, D.D., Longo, D.L., Ferrucci, L., Schlessinger, D., Cucca, F., and Terracciano, A. Personality traits and leptin. Psychosom. Med. 75: 505-9, 2013. PMID: 23697464

862. Longo, D.L. Personalized cancer care is not new. Oncologist 18: 644-5, 2013. PMID: 23814158

863. Longo, D.L. Covert operations: cancer’s many subversive tactics in overcoming host defenses. Trans. Am. Clin. Climatol. Assoc. 124: 163-73, 2013. PMID: 23874020

864. Longo, D.L. Reply to Borchmann, et al. J. Clin. Oncol. 31: 3046, 2013. PMID: 23943827

865. Chen, K.H., Dasgupta, A., Ding, J., Indig, F.E., Ghosh, P., and Longo, D.L. Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J. 28: 382-94, 2014. PMID: 24081906

866. Bouchlaka, M.N., Sckisel, G.D., Chen, M., Mirsolan, A., Zamora, A.E., Maverakis, E., Wilkins, D.E., Alderson, K.L., Hsiao, H.H., Weiss, J.M., Monjazeb, A.M., Hesdorffer, C., Ferrucci, L., Longo, D.L., Blazar, B.R., Wiltrout, R.H., Redelman, D., Taub, D.D., and Murphy, W.J. J. Exp. Med. 210: 2223-37, 2013. PMID: 24081947

867. Jimenez-Gomez, Y., Mattison, J.A., Pearson, K.J., Martin-Montalvo, A., Palacios, H.H., Sossong, A.M., Ward, T.M., Younts, C.M., Lewis, K., Allard, J.S., Longo, D.L., Belman J.P., Malagon M.M., Navas, P., Sanghvi, M., Moaddel, R., Tilmont, E.M., Herbert, R.L., Morrell, C.H., Egan, J.M., Baur, J.A., Ferrucci, L., Bogan, J.S., Bernier, M., and de Cabo, R. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab.18: 533-45, 2013. PMID: 24093677

868. Chabner, B.A., Longo, D.L., editors, Harrison’s Manual of Oncology, 2md edition, McGraw-Hill, New York, 2014.

869. Curti, B.D., Longo, D.L. Intensive care of the cancer patient. In: Critical Care Medicine, 4th edition, Parrillo J.E., Delinger R.P., editors, Elsevier Saunders, Philadelphia, PA, 2014, pp1394-1409.

870. Layani-Bazar, A., Skornik, I., Berrebi, A., Pauker, M.H., Noy, E., Siberman, A., Albeck, M., Longo, D.L., Kalechman, Y., and Sredni, B.: Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to a drug-sensitive state. Cancer Res. Apr 3, 2014. [epub ahead of print] PMID: 24699624

871. Tuchman, S.A., Schapiro, G.R., Ershler, W.B., Badros, A., Cohen, H.J., Dispenzieri, A., Flores, I.Q., Kanapuru, B., Jurivich, D., Longo, D.L., Nourbakhsh, A., Palumbo, A., Walston, J., and Yates, J.W.: Multiple myeloma in the very old: an IASIA conference report. J. Natl. Cancer Inst. Apr 3, 2014. [epub ahead of print] PMID: 24700806

872. Gainor J.F., Longo, D.L., and Chabner, B.A. Pharmacodynamic biomarkers: falling short of the mark? Clin. Cancer Res. 20:2587-94, 2014. PMID: 24831281

873. Sharov A.A., Nishiyama, A., Quian, Y., Dudekula, D.B., Longo D.L., Schlessinger, D., and Ko, M.S. Chromatin properties of regulatory DNA probed by manipulation of transcription factors. J. Comput. Biol. Jun 11, 2014 [epub ahead of print] PMID: 24918633
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