秋山 智彦  Tomohiko Akiyama

学歴

  • 2003.3  早稲田大学理工学部 卒業
  • 2005.3  東京大学大学院新領域創成科学研究科修士課程 修了
  • 2008.3  東京大学大学院新領域創成科学研究科博士課程 修了

学位

  • 2008 Ph.D (生命科学) 取得

職歴

  • 2005.4~2008.3
    日本学術振興会特別研究員(DC1)
  • 2008.4~2011.9
    東京大学大学院新領域創成科学研究科 特任研究員
  • 2011.11~2013.9
    Laboratory of Genetics, National Institute on Aging,
    National Institutes of Health (日本学術振興会海外特別研究員)
  • 2013.10~
    慶応義塾大学医学部坂口記念システム医学講座 特任助教

研究業績

2017年
1. Akiyama T, Wakabayashi S, Soma A, Sato S, Nakatake Y, Oda M, Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SBH, Ko MSH
Epigenetic manipulation facilitates the generation of skeletal muscle cells from pluripotent stem cells
Stem Cells International. Volume 2017 (2017), Article ID 7215010, 8 pages
2. Goparaju SK, Kohda K, Ibata K, Soma A, Nakatake Y, Akiyama T, Wakabayashi S, Matsushita M, Sakota M, Kimura H, Yuzaki M, Ko SB, Ko MS.
Rapid differentiation of human pluripotent stem cells into functional neurons by mRNAs encoding transcription factors. Sci Rep. 2017 Feb 13;7:42367. doi: 10.1038/srep42367. PMID: 28205555
3. Hirayama M, Ko SB, Kawakita T, Akiyama T, Goparaju SK, Soma A, Nakatake Y, Sakota M, Chikazawa-Nohtomi N, Shimmura S, Tsubota K, Ko MS.
Identification of transcription factors that promote the differentiation of human pluripotent stem cells into lacrimal gland epithelium-like cells. npj Aging and Mechanisms of Disease 2017; 3: 1. doi:10.1038/s41514-016-0001-8
2016年
4. Akiyama T, Wakabayashi S, Atsumi Soma, Saeko Sato, Nakatake Y, Oda M, Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SBH, Ko MSH.
Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells 
Development 2016 143:3674-3685.
5. Ishiguro K, Monti M, Akiyama T, Kimura H, Chikazawa-Nohtomi N, Sakota M, Sato S, Redi CA, Ko SBH, Ko MSH.
Zscan4 is expressed specifically during late meiotic prophase in both spermatogenesis and oogenesis.
In Vitro Cellular & Developmental Biology – Animal
6. Ishiguro K, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SBH, Ko MSH.
Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.
In Vitro Cellular & Developmental Biology – Animal
7. 秋山 智彦
マウスES細胞のゲノム安定性に寄与するクロマチンリセット機構
招待講演 理化学研究所バイオリソースセンター  2016年1月26日
2015年
8. Akiyama T, Xin L, Oda M, Sharov AA, Amano M, Piao Y, Cadet S, Dudekula DB, Qian Y, Wang W, Ko SBH, Ko MSH.
Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells.
DNA Research. 2015, 5:307-318.
9. Tsukada Y, Akiyama T, Nakayama KI.
Maternal TET3 is dispensable for embryonic development but is required for neonatal growth.
Scientific Reports. 2015, 5:15876.
10. 秋山 智彦、小田 真由美、石黒 啓一郎、洪 繁、洪 実
Zscan4による特異的なヘテロクロマチン制御を介したマウスES細胞のゲノム安定化
 細胞工学 2015年11月号特集
11. 秋山 智彦、中武 悠樹、山水 康平、相馬 淳美、洪 繁、洪 実
転写因子操作による多能性幹細胞からの自在な細胞分化誘導技術の確立を目指して
日本臨牀 2015年 6月増刊号
2014年
12. Yukawa M*, Akiyama T*(*同等貢献), Franke V*, Mise N, Isagawa T, Suzuki Y, Suzuki MG, Vlahovicek K, Abe K, Aburatani H, Aoki F.
Genome-Wide Analysis of the Chromatin Composition of Histone H2A and H3 Variants in Mouse Embryonic Stem Cells
PLoS One. 2014;9 (3):e92689.
13. 秋山 智彦、洪 繁、洪 実
着床前期胚、生殖細胞、幹細胞、にかかわるZSCAN4
実験医学 2014年4月号特集
2013年
14. Amano T, Hirata T, Falco G, Monti M, Sharova LV, Amano M, Sheer S, Hoang HG, Piao Y, Stagg CA, Yamamizu K, Akiyama T, Ko MS.
Zscan4 restores the developmental potency of embryonic stem cells.
Nat Commun. 2013;4:1966.
2012年
15. Kawamura M, Akiyama T, Tsukamoto S, Suzuki MG, Aoki F.
The expression and nuclear deposition of histone h3.1 in murine oocytes and preimplantation embryos.
J Reprod Dev. 2012;58(5):557-62.
2011年
16. Akiyama T, Suzuki O, Matsuda J, Aoki F.
Dynamic replacement of histone H3 variants reprograms epigenetic marks in early mouse embryos.
PLoS Genetics. 7:e1002279 (2011)
17. Nashun B*, Akiyama T*(*同等貢献), Suzuki MG, Aoki F.
Dramatic replacement of histone variants during genome remodeling in nuclear-transferred embryos.
Epigenetics. 6:1489-97 (2011)
2010年
18. Nashun B, Yukawa M, Liu H, Akiyama T, Aoki F.
Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice.
Development. 2010 Nov;137(22):3785-94.
2008年
19. Ooga M, Inoue A, Kageyama S, Akiyama T, Nagata M, Aoki F.
Changes in H3K79 methylation during preimplantation development in mice.
Biol Reprod. 2008 Mar;78(3):413-24.
2007年
20. Aoki F, Akiyama T.
Involvement of histone modification and histone variants replacement in genome reprogramming during oogenesis and preimplantation development. Tanpakushitsu Kakusan Koso. 2007 Dec;52(16 Suppl):2170-6. (Japanese)
21. Inoue A, Akiyama T, Nagata M, Aoki F.
The perivitelline space-forming capacity of mouse oocytes is associated with meiotic competence.
J Reprod Dev. 2007 Oct;53(5):1043-52.
22. Matsuhashi T, Akiyama T, Aoki F, Sakai S.
Changes in histone modification upon activation of dormant mouse blastocysts.
Anim Sci J. 2007 Dec;78(6): 575-86.
2006年
23. Akiyama T, Aoki F.
Chromatin modifications regulate chromosome segregation in meiosis.
Saibou Kougaku 2006; 25:1064-1067. (Japanese)
24. Akiyama T, Nagata M, Aoki F.
Inadequate histone deacetylation during oocyte meiosis causes aneuploidy and embryo death in mice.
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7339-44.
2004年
25. Akiyama T, Kim JM, Nagata M, Aoki F.
Regulation of histone acetylation during meiotic maturation in mouse oocytes. Mol Reprod Dev. 2004 Oct;69(2):222-7.