実教授 HP用写真 - 小

小田 真由美Mayumi Oda

学歴

  • 1993.4 東京大学理科二類入学
  • 1997.3 農学部獣医学科卒業
  • 2003.3 農学生命科学研究科・博士課程終了(細胞生化学研究室)

学位

  • 2003Ph.D(獣医学)取得
    学位論文「胎盤と栄養膜幹細胞のエピジェネティック分子機構」

職歴

  • 2004 ~
    日本学術振興会特別研究員
  • 2006 ~
    Albert Einstein College of Medicine、Research Associate
  • 2008.4 ~ 2012.6
    慶應義塾大学医学部・総合医科学研究センター 循環器内科教室・特任助教
  • 2012.7 ~
    慶応義塾大学医学部坂口記念システム医学講座
    Tenure Track助教

研究テーマ

  • エピジェネティクス、幹細胞、細胞分化、病態発生分子機構

研究業績

Research Map [link]
KAKEN [link]
2017年
1. Akiyama T, Wakabayashi S, Soma A, Sato S, Nakatake Y, Oda M, Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SBH, Ko MSH.
Epigenetic Manipulation Facilitates the Generation of Skeletal Muscle Cells from Pluripotent Stem Cells.
Stem Cells Int. 2017;2017:7215010. doi: 10.1155/2017/7215010. Epub 2017 Apr 9.
2. Arai Y, Takahashi D, Asano K, Tanaka M, Oda M, Ko SBH, Ko MSH, Mandai S, Nomura N, Rai T, Uchida S, Sohara E.
Salt suppresses IFNγ inducible chemokines through the IFNγ-JAK1-STAT1 signaling pathway in proximal tubular cells.
Sci Rep. 2017 Apr 20;7:46580. doi: 10.1038/srep46580.
2016年
3. Akiyama T, Wakabayashi S, Soma A, Sato S, Nakatake Y, Oda M, Murakami M, Sakota M, Chikazawa-Nohtomi N, Ko SB, Ko MS.
Transient ectopic expression of the histone demethylase JMJD3 accelerates the differentiation of human pluripotent stem cells.
Development. 2016 Oct 15;143(20):3674-3685.
4. Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS.
Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos.
In Vitro Cell Dev Biol Anim. 2016 Oct 3.
5. Kunitomi A, Yuasa S, Sugiyama F, Saito Y, Seki T, Kusumoto D, Kashimura S, Takei M, Tohyama S, Hashimoto H, Egashira T, Tanimoto Y, Mizuno S, Tanaka S, Okuno H, Yamazawa K, Watanabe H, Oda M, Kaneda R, Matsuzaki Y, Nagai T, Okano H, Yagami K, Tanaka M, Fukuda K.
H1foo Has a Pivotal Role in Qualifying Induced Pluripotent Stem Cells.
Stem cell reports   6(6) 825-833   2016年6月

2015年
6. 秋山智彦、小田真由美、石黒啓一郎、洪 繁、洪 実
Zscan4による特異的なヘテロクロマチン制御を介したマウスES細胞のゲノム安定化
細胞工学 Vol.34, No.11, Page1052-1056
秀潤社 2015年10月22日発行
7. Akiyama T, Xin L, Oda M, Sharov AA, Amano M, Piao Y, Cadet JS, Dudekula DB, Qian Y, Wang W, Ko SB, Ko MS.
Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells.
DNA research : an international journal for rapid publication of reports on genes and genomes   22(5) 307-318   2015年8月

2012年
8. Kodo K, Nishizawa T, Furutani M, Arai S, Ishihara K, Oda M, Makino S, Fukuda K, Takahashi T, Matsuoka R, Nakanishi T, Yamagishi H.
Genetic Analysis of Essential Cardiac Transcription Factors in 256 Patients With Non-Syndromic Congenital Heart Defects.
Circulation journal 2012
2011年
9. Suzuki M, Oda M, Ramos MP, Pascual M, Lau K, Stasiek E, Agyiri F, Thompson RF, Glass JL, Jing Q, Sandstrom R, Fazzari MJ, Hansen RS, Stamatoyannopoulos JA, McLellan AS, Greally JM.
Late-replicating heterochromatin is characterized by decreased cytosine methylation in the human genome.
Genome Res. 2011 Nov;21(11):1833-40.
2010年
10. Seki T, Yuasa S, Oda M, Egashira T, Yae K, Kusumoto D, Nakata H, Tohyama S, Hashimoto H, Kodaira M, Okada Y, Seimiya H, Fusaki N, Hasegawa M, Fukuda K.
Generation of induced pluripotent stem cells from human terminally differentiated circulating T cells.
Cell Stem Cell. 2010 Jul 2;7(1):11-4.
11. Oda M, Shiota K, Tanaka S.
Trophoblast cell lineage in cloned mouse embryos.
Dev Growth Differ. 2010 Apr;52(3):285-91. Review.
2009年
12. Oda M, Tanaka S, Yamazaki Y, Ohta H, Iwatani M, Suzuki M, Ohgane J, Hattori N, Yanagimachi R, Wakayama T, Shiota K.
Establishment of trophoblast stem cell lines from somatic cell nuclear-transferred embryos.
Proc Natl Acad Sci U S A. 2009;106(38):16293-7
13. Oda M, Glass JL, Thompson RF, Mo Y, Olivier EN, Figueroa ME, Selzer RR, Richmond TA, Zhang X, Dannenberg L, Green RD, Melnick A, Hatchwell E, Bouhassira EE, Verma A, Suzuki M, Greally JM.
High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.
Nucleic Acids Res. 2009 Jul;37(12):3829-39
14. Oda M, Greally JM.
The HELP assay.
Methods Mol Biol. 2009;507:77-87.
2007年
15. Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, Garber M, Gentles AJ, Goodstadt L, Heger A, Jurka J, Kamal M, Mauceli E, Searle SM, Sharpe T, Baker ML, Batzer MA, Benos PV, Belov K, Clamp M, Cook A, Cuff J, Das R, Davidow L, Deakin JE, Fazzari MJ, Glass JL, Grabherr M, Greally JM, Gu W, Hore TA, Huttley GA, Kleber M, Jirtle RL, Koina E, Lee JT, Mahony S, Marra MA, Miller RD, Nicholls RD,
Oda M, Papenfuss AT, Parra ZE, Pollock DD, Ray DA, Schein JE, Speed TP, Thompson K, VandeBerg JL, Wade CM, Walker JA, Waters PD, Webber C, Weidman JR, Xie X, Zody MC, Broad Institute Genome Sequencing Platform, Broad Institute Whole Genome Assembly Team, Graves JA, Ponting CP, Breen M, Samollow PB, Lander ES, Lindblad-Toh K.
Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences.
Nature. 2007 May 10;447(7141):167-77.
16. Hamada Y, Hiroe T, Suzuki Y, Oda M, Tsujimoto Y, Coleman JR, Tanaka S.
Notch2 is required for formation of the placental circulatory system, but not for cell-type specification in the developing mouse placenta.
Differentiation. 2007 Mar;75(3):268-78.
2006年
17. Oda M, Shiota K, Tanaka S.
Trophoblast stem cells.
Methods Enzymol. 2006;419:387-400. Review.
2002年
18. Ohgane J, Hattori N, Oda M, Tanaka S, Shiota K.
Differentiation of trophoblast lineage is associated with DNA methylation and demethylation.
Biochemical and biophysical research communications  290 701-706  2002年1月
2001年
19. Tanaka S, Oda M, Toyoshima Y, Wakayama T, Tanaka M, Yoshida N, Hattori N, Ohgane J, Yanagimachi R, Shiota K.
Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer.
Biology of reproduction   65 1813-1821   2001年12月
20. Oda M, Sun W, Hattori N, Tanaka S, Shiota K.
PAL31 expression in rat trophoblast giant cells.
Biochemical and biophysical research communications  287 721-726  2001年9月
21. Yan J, Tanaka S, Oda M, Makino T, Ohgane J, Shiota K.
Retinoic acid promotes differentiation of trophoblast stem cells to a giant cell fate.
Developmental biology   235 422-432  2001年7月
1998年
22. Iwatsuki K, Oda M, Sun W, Tanaka S, Ogawa T, Shiota K.
Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family, PRL-like protein H.
Endocrinology   139 4976-4983   1998年12月
23. Hattori N, Nukada T, Oda M, Tanaka S, Ogawa T, Shiota K.
Evaluation of the role of N-linked oligosaccharides in rat placental lactogen action by site-directed mutagenesis.
Endocrine journal   45 659-674   1998年10月
Linkedin
http://www.linkedin.com/pub/mayumi-oda/35/b3a/2a7